SLC14A1 (solute carrier family 14 member 1 (Kidd blood group))

2003-11-01  

Identity

HGNC
SLC14A1
LOCATION
18q12.3
LOCUSID
6563
ALIAS
HUT11,HsT1341,JK,Jk(b),RACH1,RACH2,UT-B1,UT1,UTE

Other Information

Locus ID:

NCBI: 6563
MIM: 613868
HGNC: 10918
Ensembl: ENSG00000141469

Variants:

dbSNP: 6563
ClinVar: 6563
TCGA: ENSG00000141469
COSMIC: SLC14A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141469ENST00000321925Q13336
ENSG00000141469ENST00000321925G0W2N5
ENSG00000141469ENST00000402943B4DFJ8
ENSG00000141469ENST00000415427Q13336
ENSG00000141469ENST00000436407Q13336
ENSG00000141469ENST00000502059F6WB45
ENSG00000141469ENST00000535474F5GWS2
ENSG00000141469ENST00000586056M0QYS8
ENSG00000141469ENST00000586142Q13336
ENSG00000141469ENST00000586142G0W2N5
ENSG00000141469ENST00000586951Q13336
ENSG00000141469ENST00000586951G0W2N5
ENSG00000141469ENST00000587601K7EJ54
ENSG00000141469ENST00000588179K7EQM7
ENSG00000141469ENST00000589322F5GWS2
ENSG00000141469ENST00000589700E9NSU1
ENSG00000141469ENST00000590246K7ESL3
ENSG00000141469ENST00000590377K7EJF6
ENSG00000141469ENST00000619403E9NSU1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
217501092011European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.59
189970042009Widespread balancing selection and pathogen-driven selection at blood group antigen genes.54
218249762011A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3.42
227337302012Structure and permeation mechanism of a mammalian urea transporter.26
234865182013A novel small-molecule thienoquinolin urea transporter inhibitor acts as a potential diuretic.24
222233682012Association of lung adenocarcinoma clinical stage with gene expression pattern in noninvolved lung tissue.17
237542492013Differential urinary specific gravity as a molecular phenotype of the bladder cancer genetic association in the urea transporter gene, SLC14A1.15
120938132002Antigenic and functional properties of the human red blood cell urea transporter hUT-B1.14
149852362004Identification and characterization of a Kidd antigen/UT-B urea transporter expressed in human colon.14

Citation

Dessen P

SLC14A1 (solute carrier family 14 member 1 (Kidd blood group))

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42310/slc14a1