SLC16A7 (solute carrier family 16 member 7)

2008-05-01  

Identity

HGNC
LOCATION
12q14.1
LOCUSID
ALIAS
MCT2
FUSION GENES

Other Information

Locus ID:

NCBI: 9194
MIM: 603654
HGNC: 10928
Ensembl: ENSG00000118596

Variants:

dbSNP: 9194
ClinVar: 9194
TCGA: ENSG00000118596
COSMIC: SLC16A7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118596ENST00000261187O60669
ENSG00000118596ENST00000261187A0A024RBB2
ENSG00000118596ENST00000546459F8VVU7
ENSG00000118596ENST00000547379O60669
ENSG00000118596ENST00000547379A0A024RBB2
ENSG00000118596ENST00000548444F8VS95
ENSG00000118596ENST00000548610F8W0N3
ENSG00000118596ENST00000549033F8W1M4
ENSG00000118596ENST00000549305F8VYZ2
ENSG00000118596ENST00000549465F8W0U4
ENSG00000118596ENST00000549928F8VVU7
ENSG00000118596ENST00000550062F8VQS4
ENSG00000118596ENST00000551877F8VXG4
ENSG00000118596ENST00000552024O60669
ENSG00000118596ENST00000552024A0A024RBB2
ENSG00000118596ENST00000552432O60669
ENSG00000118596ENST00000552432A0A024RBB2

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Proton-coupled monocarboxylate transportREACTOMER-HSA-433692

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443433Arthritis, Juvenile RheumatoidDiseaseClinicalAnnotationassociatedPD
PA450428methotrexateChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
368143182023Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis.4
368143182023Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis.4
359396822022Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function.6
359396822022Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function.6
324150672020Cooperative transport mechanism of human monocarboxylate transporter 2.23
328195652020Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 4.1
324150672020Cooperative transport mechanism of human monocarboxylate transporter 2.23
328195652020Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 4.1
305211302019The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer.7
305211302019The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer.7
302978752018MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG.17
302978752018MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG.17
282815252017Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate.59
282815252017Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate.59
254920482015Polymorphisms of monocarboxylate transporter genes are associated with clinical outcomes in patients with colorectal cancer.14

Citation

Dessen P

SLC16A7 (solute carrier family 16 member 7)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50149/slc16a7