SLC18A1 (solute carrier family 18 member A1)

2016-12-01  

Identity

HGNC
LOCATION
8p21.3
LOCUSID
ALIAS
CGAT,VAT1,VMAT1

Other Information

Locus ID:

NCBI: 6570
MIM: 193002
HGNC: 10934
Ensembl: ENSG00000036565

Variants:

dbSNP: 6570
ClinVar: 6570
TCGA: ENSG00000036565
COSMIC: SLC18A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000036565ENST00000265808P54219
ENSG00000036565ENST00000276373P54219
ENSG00000036565ENST00000381608P54219
ENSG00000036565ENST00000437980P54219
ENSG00000036565ENST00000440926P54219
ENSG00000036565ENST00000517776Q96GL6
ENSG00000036565ENST00000519026P54219
ENSG00000036565ENST00000522513E5RK12

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Parkinson's diseaseKEGGhsa05012
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Serotonergic synapseKEGGhsa04726
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Na+/Cl- dependent neurotransmitter transportersREACTOMER-HSA-442660

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
204680642010Association study of 182 candidate genes in anorexia nervosa.30
169367052006Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder.23
169367052006Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder.23
184516392008Association between polymorphisms in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) on chromosome 8p and schizophrenia.17
184516392008Association between polymorphisms in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) on chromosome 8p and schizophrenia.17
161891772005Different expression of catecholamine transporters in phaeochromocytomas from patients with von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2.16
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
171345142006Association study of the vesicular monoamine transporter 1 (VMAT1) gene with schizophrenia in a Japanese population.14
128076982003Norepinephrine transport by the extraneuronal monoamine transporter in human bronchial arterial smooth muscle cells.13

Citation

Dessen P

SLC18A1 (solute carrier family 18 member A1)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56662/slc18a1