Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SLC18A2 (solute carrier family 18 member A2)

Identity

Alias_namesVMAT2
solute carrier family 18 (vesicular monoamine transporter)
Alias_symbol (synonym)SVMT
SVAT
Other aliasPKDYS2
VAT2
HGNC (Hugo) SLC18A2
LocusID (NCBI) 6571
Atlas_Id 49830
Location 10q25.3  [Link to chromosome band 10q25]
Location_base_pair Starts at 117241073 and ends at 117279430 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SLC18A2   10935
Cards
Entrez_Gene (NCBI)SLC18A2  6571  solute carrier family 18 member A2
AliasesPKDYS2; SVAT; SVMT; VAT2; 
VMAT2
GeneCards (Weizmann)SLC18A2
Ensembl hg19 (Hinxton)ENSG00000165646 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165646 [Gene_View]  ENSG00000165646 [Sequence]  chr10:117241073-117279430 [Contig_View]  SLC18A2 [Vega]
ICGC DataPortalENSG00000165646
TCGA cBioPortalSLC18A2
AceView (NCBI)SLC18A2
Genatlas (Paris)SLC18A2
WikiGenes6571
SOURCE (Princeton)SLC18A2
Genetics Home Reference (NIH)SLC18A2
Genomic and cartography
GoldenPath hg38 (UCSC)SLC18A2  -     chr10:117241073-117279430 +  10q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC18A2  -     10q25.3   [Description]    (hg19-Feb_2009)
EnsemblSLC18A2 - 10q25.3 [CytoView hg19]  SLC18A2 - 10q25.3 [CytoView hg38]
Mapping of homologs : NCBISLC18A2 [Mapview hg19]  SLC18A2 [Mapview hg38]
OMIM193001   618049   
Gene and transcription
Genbank (Entrez)AK314997 BC030593 BC108927 BC108928 BQ416859
RefSeq transcript (Entrez)NM_003054
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLC18A2
Cluster EST : UnigeneHs.596992 [ NCBI ]
CGAP (NCI)Hs.596992
Alternative Splicing GalleryENSG00000165646
Gene ExpressionSLC18A2 [ NCBI-GEO ]   SLC18A2 [ EBI - ARRAY_EXPRESS ]   SLC18A2 [ SEEK ]   SLC18A2 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC18A2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6571
GTEX Portal (Tissue expression)SLC18A2
Human Protein AtlasENSG00000165646-SLC18A2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ05940   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ05940  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ05940
Splice isoforms : SwissVarQ05940
PhosPhoSitePlusQ05940
Domaine pattern : Prosite (Expaxy)MFS (PS50850)   
Domains : Interpro (EBI)MFS    MFS_dom    MFS_trans_sf   
Domain families : Pfam (Sanger)MFS_1 (PF07690)   
Domain families : Pfam (NCBI)pfam07690   
Conserved Domain (NCBI)SLC18A2
DMDM Disease mutations6571
Blocks (Seattle)SLC18A2
SuperfamilyQ05940
Human Protein Atlas [tissue]ENSG00000165646-SLC18A2 [tissue]
Peptide AtlasQ05940
HPRD01896
IPIIPI00016759   
Protein Interaction databases
DIP (DOE-UCLA)Q05940
IntAct (EBI)Q05940
FunCoupENSG00000165646
BioGRIDSLC18A2
STRING (EMBL)SLC18A2
ZODIACSLC18A2
Ontologies - Pathways
QuickGOQ05940
Ontology : AmiGOresponse to amphetamine  serotonin:sodium symporter activity  plasma membrane  integral component of plasma membrane  neurotransmitter transport  chemical synaptic transmission  neurotransmitter secretion  locomotory behavior  synaptic vesicle  monoamine transmembrane transporter activity  monoamine transmembrane transporter activity  post-embryonic development  aminergic neurotransmitter loading into synaptic vesicle  monoamine transport  dopamine transport  membrane  synaptic vesicle membrane  sequestering of neurotransmitter  terminal bouton  serotonin uptake  transmembrane transport  clathrin-sculpted monoamine transport vesicle membrane  dopaminergic synapse  neurotransmitter loading into synaptic vesicle  negative regulation of reactive oxygen species biosynthetic process  
Ontology : EGO-EBIresponse to amphetamine  serotonin:sodium symporter activity  plasma membrane  integral component of plasma membrane  neurotransmitter transport  chemical synaptic transmission  neurotransmitter secretion  locomotory behavior  synaptic vesicle  monoamine transmembrane transporter activity  monoamine transmembrane transporter activity  post-embryonic development  aminergic neurotransmitter loading into synaptic vesicle  monoamine transport  dopamine transport  membrane  synaptic vesicle membrane  sequestering of neurotransmitter  terminal bouton  serotonin uptake  transmembrane transport  clathrin-sculpted monoamine transport vesicle membrane  dopaminergic synapse  neurotransmitter loading into synaptic vesicle  negative regulation of reactive oxygen species biosynthetic process  
Pathways : KEGGSynaptic vesicle cycle    Serotonergic synapse    Dopaminergic synapse    Parkinson's disease    Cocaine addiction    Amphetamine addiction    Alcoholism   
NDEx NetworkSLC18A2
Atlas of Cancer Signalling NetworkSLC18A2
Wikipedia pathwaysSLC18A2
Orthology - Evolution
OrthoDB6571
GeneTree (enSembl)ENSG00000165646
Phylogenetic Trees/Animal Genes : TreeFamSLC18A2
HOGENOMQ05940
Homologs : HomoloGeneSLC18A2
Homology/Alignments : Family Browser (UCSC)SLC18A2
Gene fusions - Rearrangements
Fusion : QuiverSLC18A2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC18A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC18A2
dbVarSLC18A2
ClinVarSLC18A2
1000_GenomesSLC18A2 
Exome Variant ServerSLC18A2
ExAC (Exome Aggregation Consortium)ENSG00000165646
GNOMAD BrowserENSG00000165646
Varsome BrowserSLC18A2
Genetic variants : HAPMAP6571
Genomic Variants (DGV)SLC18A2 [DGVbeta]
DECIPHERSLC18A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC18A2 
Mutations
ICGC Data PortalSLC18A2 
TCGA Data PortalSLC18A2 
Broad Tumor PortalSLC18A2
OASIS PortalSLC18A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC18A2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC18A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC18A2
DgiDB (Drug Gene Interaction Database)SLC18A2
DoCM (Curated mutations)SLC18A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC18A2 (select a term)
intoGenSLC18A2
Cancer3DSLC18A2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM193001    618049   
Orphanet22091   
DisGeNETSLC18A2
MedgenSLC18A2
Genetic Testing Registry SLC18A2
NextProtQ05940 [Medical]
TSGene6571
GENETestsSLC18A2
Target ValidationSLC18A2
Huge Navigator SLC18A2 [HugePedia]
snp3D : Map Gene to Disease6571
BioCentury BCIQSLC18A2
ClinGenSLC18A2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6571
Chemical/Pharm GKB GenePA325
Clinical trialSLC18A2
Miscellaneous
canSAR (ICR)SLC18A2 (select the gene name)
DataMed IndexSLC18A2
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC18A2
EVEXSLC18A2
GoPubMedSLC18A2
iHOPSLC18A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Feb 14 16:57:23 CET 2019
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