Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SLC1A2 (solute carrier family 1 member 2)

Identity

Alias_namessolute carrier family 1 (glial high affinity glutamate transporter)
Alias_symbol (synonym)GLT-1
EAAT2
Other aliasEIEE41
HBGT
HGNC (Hugo) SLC1A2
LocusID (NCBI) 6506
Atlas_Id 52325
Location 11p13  [Link to chromosome band 11p13]
Location_base_pair Starts at 35251205 and ends at 35420063 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD44 (11p13) / SLC1A2 (11p13)FERMT2 (14q22.1) / SLC1A2 (11p13)MRO (18q21.2) / SLC1A2 (11p13)
RNU5F-1 (1q41) / SLC1A2 (11p13)SLC1A2 (11p13) / AP4M1 (7q22.1)SLC1A2 (11p13) / SLC1A2 (11p13)
SLC50A1 (1q22) / SLC1A2 (11p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC1A2   10940
Cards
Entrez_Gene (NCBI)SLC1A2  6506  solute carrier family 1 member 2
AliasesEAAT2; EIEE41; GLT-1; HBGT
GeneCards (Weizmann)SLC1A2
Ensembl hg19 (Hinxton)ENSG00000110436 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110436 [Gene_View]  chr11:35251205-35420063 [Contig_View]  SLC1A2 [Vega]
ICGC DataPortalENSG00000110436
TCGA cBioPortalSLC1A2
AceView (NCBI)SLC1A2
Genatlas (Paris)SLC1A2
WikiGenes6506
SOURCE (Princeton)SLC1A2
Genetics Home Reference (NIH)SLC1A2
Genomic and cartography
GoldenPath hg38 (UCSC)SLC1A2  -     chr11:35251205-35420063 -  11p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC1A2  -     11p13   [Description]    (hg19-Feb_2009)
EnsemblSLC1A2 - 11p13 [CytoView hg19]  SLC1A2 - 11p13 [CytoView hg38]
Mapping of homologs : NCBISLC1A2 [Mapview hg19]  SLC1A2 [Mapview hg38]
OMIM600300   617105   
Gene and transcription
Genbank (Entrez)AB209444 AF131756 AK054855 AK057674 AK090810
RefSeq transcript (Entrez)NM_001195728 NM_001252652 NM_004171
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLC1A2
Cluster EST : UnigeneHs.661429 [ NCBI ]
CGAP (NCI)Hs.661429
Alternative Splicing GalleryENSG00000110436
Gene ExpressionSLC1A2 [ NCBI-GEO ]   SLC1A2 [ EBI - ARRAY_EXPRESS ]   SLC1A2 [ SEEK ]   SLC1A2 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC1A2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6506
GTEX Portal (Tissue expression)SLC1A2
Human Protein AtlasENSG00000110436-SLC1A2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43004   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP43004  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP43004
Splice isoforms : SwissVarP43004
PhosPhoSitePlusP43004
Domaine pattern : Prosite (Expaxy)NA_DICARBOXYL_SYMP_1 (PS00713)    NA_DICARBOXYL_SYMP_2 (PS00714)   
Domains : Interpro (EBI)Na-dicarboxylate_symporter    Na-dicarboxylate_symporter_CS   
Domain families : Pfam (Sanger)SDF (PF00375)   
Domain families : Pfam (NCBI)pfam00375   
Conserved Domain (NCBI)SLC1A2
DMDM Disease mutations6506
Blocks (Seattle)SLC1A2
SuperfamilyP43004
Human Protein Atlas [tissue]ENSG00000110436-SLC1A2 [tissue]
Peptide AtlasP43004
HPRD02625
IPIIPI00300020   IPI00794423   IPI00795525   IPI00980933   IPI00981720   
Protein Interaction databases
DIP (DOE-UCLA)P43004
IntAct (EBI)P43004
FunCoupENSG00000110436
BioGRIDSLC1A2
STRING (EMBL)SLC1A2
ZODIACSLC1A2
Ontologies - Pathways
QuickGOP43004
Ontology : AmiGOL-glutamate transmembrane transporter activity  high-affinity glutamate transmembrane transporter activity  protein binding  plasma membrane  ion transport  chemical synaptic transmission  visual behavior  response to wounding  cell surface  multicellular organism aging  glutamate secretion  amino acid transmembrane transporter activity  glutamate:sodium symporter activity  membrane  integral component of membrane  telencephalon development  adult behavior  axolemma  cellular response to extracellular stimulus  multicellular organism growth  response to drug  response to amino acid  positive regulation of glucose import  L-glutamate import  D-aspartate import  L-glutamate transmembrane transport  
Ontology : EGO-EBIL-glutamate transmembrane transporter activity  high-affinity glutamate transmembrane transporter activity  protein binding  plasma membrane  ion transport  chemical synaptic transmission  visual behavior  response to wounding  cell surface  multicellular organism aging  glutamate secretion  amino acid transmembrane transporter activity  glutamate:sodium symporter activity  membrane  integral component of membrane  telencephalon development  adult behavior  axolemma  cellular response to extracellular stimulus  multicellular organism growth  response to drug  response to amino acid  positive regulation of glucose import  L-glutamate import  D-aspartate import  L-glutamate transmembrane transport  
Pathways : KEGGGlutamatergic synapse    Amyotrophic lateral sclerosis (ALS)   
NDEx NetworkSLC1A2
Atlas of Cancer Signalling NetworkSLC1A2
Wikipedia pathwaysSLC1A2
Orthology - Evolution
OrthoDB6506
GeneTree (enSembl)ENSG00000110436
Phylogenetic Trees/Animal Genes : TreeFamSLC1A2
HOVERGENP43004
HOGENOMP43004
Homologs : HomoloGeneSLC1A2
Homology/Alignments : Family Browser (UCSC)SLC1A2
Gene fusions - Rearrangements
Fusion: Tumor Portal SLC1A2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC1A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC1A2
dbVarSLC1A2
ClinVarSLC1A2
1000_GenomesSLC1A2 
Exome Variant ServerSLC1A2
ExAC (Exome Aggregation Consortium)ENSG00000110436
GNOMAD BrowserENSG00000110436
Genetic variants : HAPMAP6506
Genomic Variants (DGV)SLC1A2 [DGVbeta]
DECIPHERSLC1A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC1A2 
Mutations
ICGC Data PortalSLC1A2 
TCGA Data PortalSLC1A2 
Broad Tumor PortalSLC1A2
OASIS PortalSLC1A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC1A2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC1A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC1A2
DgiDB (Drug Gene Interaction Database)SLC1A2
DoCM (Curated mutations)SLC1A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC1A2 (select a term)
intoGenSLC1A2
Cancer3DSLC1A2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600300    617105   
Orphanet
MedgenSLC1A2
Genetic Testing Registry SLC1A2
NextProtP43004 [Medical]
TSGene6506
GENETestsSLC1A2
Target ValidationSLC1A2
Huge Navigator SLC1A2 [HugePedia]
snp3D : Map Gene to Disease6506
BioCentury BCIQSLC1A2
ClinGenSLC1A2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6506
Chemical/Pharm GKB GenePA35827
Clinical trialSLC1A2
Miscellaneous
canSAR (ICR)SLC1A2 (select the gene name)
Probes
Litterature
PubMed133 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC1A2
EVEXSLC1A2
GoPubMedSLC1A2
iHOPSLC1A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:11:06 CET 2017

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