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SLC1A2 (solute carrier family 1 member 2)

Identity

Alias (NCBI)DEE41
EAAT2
EIEE41
GLT-1
HBGT
HGNC (Hugo) SLC1A2
HGNC Alias symbGLT-1
EAAT2
HGNC Previous namesolute carrier family 1 (glial high affinity glutamate transporter), member 2
LocusID (NCBI) 6506
Atlas_Id 52325
Location 11p13  [Link to chromosome band 11p13]
Location_base_pair Starts at 35251205 and ends at 35419558 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD44 (11p13) / SLC1A2 (11p13)FERMT2 (14q22.1) / SLC1A2 (11p13)MRO (18q21.2) / SLC1A2 (11p13)
RNU5F-1 (1q41) / SLC1A2 (11p13)SLC1A2 (11p13) / AP4M1 (7q22.1)SLC1A2 (11p13) / SLC1A2 (11p13)
SLC50A1 (1q22) / SLC1A2 (11p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SLC1A2   10940
Cards
Entrez_Gene (NCBI)SLC1A2    solute carrier family 1 member 2
AliasesDEE41; EAAT2; EIEE41; GLT-1; 
HBGT
GeneCards (Weizmann)SLC1A2
Ensembl hg19 (Hinxton)ENSG00000110436 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110436 [Gene_View]  ENSG00000110436 [Sequence]  chr11:35251205-35419558 [Contig_View]  SLC1A2 [Vega]
ICGC DataPortalENSG00000110436
TCGA cBioPortalSLC1A2
AceView (NCBI)SLC1A2
Genatlas (Paris)SLC1A2
SOURCE (Princeton)SLC1A2
Genetics Home Reference (NIH)SLC1A2
Genomic and cartography
GoldenPath hg38 (UCSC)SLC1A2  -     chr11:35251205-35419558 -  11p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC1A2  -     11p13   [Description]    (hg19-Feb_2009)
GoldenPathSLC1A2 - 11p13 [CytoView hg19]  SLC1A2 - 11p13 [CytoView hg38]
ImmunoBaseENSG00000110436
Genome Data Viewer NCBISLC1A2 [Mapview hg19]  
OMIM600300   617105   
Gene and transcription
Genbank (Entrez)AB209444 AF131756 AK054855 AK057674 AK090810
RefSeq transcript (Entrez)NM_001195728 NM_001252652 NM_004171
Consensus coding sequences : CCDS (NCBI)SLC1A2
Gene ExpressionSLC1A2 [ NCBI-GEO ]   SLC1A2 [ EBI - ARRAY_EXPRESS ]   SLC1A2 [ SEEK ]   SLC1A2 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC1A2 [ Firebrowse - Broad ]
GenevisibleExpression of SLC1A2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6506
GTEX Portal (Tissue expression)SLC1A2
Human Protein AtlasENSG00000110436-SLC1A2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43004   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP43004  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP43004
PhosPhoSitePlusP43004
Domaine pattern : Prosite (Expaxy)NA_DICARBOXYL_SYMP_1 (PS00713)    NA_DICARBOXYL_SYMP_2 (PS00714)   
Domains : Interpro (EBI)Na-dicarboxylate_symporter    Na-dicarboxylate_symporter_CS    Na:dicarbo_symporter_sf   
Domain families : Pfam (Sanger)SDF (PF00375)   
Domain families : Pfam (NCBI)pfam00375   
Conserved Domain (NCBI)SLC1A2
SuperfamilyP43004
AlphaFold pdb e-kbP43004   
Human Protein Atlas [tissue]ENSG00000110436-SLC1A2 [tissue]
HPRD02625
Protein Interaction databases
DIP (DOE-UCLA)P43004
IntAct (EBI)P43004
BioGRIDSLC1A2
STRING (EMBL)SLC1A2
ZODIACSLC1A2
Ontologies - Pathways
QuickGOP43004
Ontology : AmiGOL-glutamate transmembrane transporter activity  high-affinity glutamate transmembrane transporter activity  protein binding  plasma membrane  integral component of plasma membrane  glutathione biosynthetic process  ion transport  neurotransmitter transport  chemical synaptic transmission  visual behavior  response to wounding  cell surface  multicellular organism aging  glutamate:sodium symporter activity  L-glutamate transmembrane transport  membrane  telencephalon development  adult behavior  axolemma  cellular response to extracellular stimulus  vesicle  cysteine transmembrane transporter activity  multicellular organism growth  response to drug  response to amino acid  cell body  neuron projection terminus  membrane raft  membrane raft  positive regulation of glucose import  metal ion binding  protein homotrimerization  transepithelial transport  L-aspartate transmembrane transport  D-aspartate import across plasma membrane  cellular response to cocaine  astrocyte projection  L-glutamate import across plasma membrane  L-glutamate import across plasma membrane  membrane protein complex  membrane protein complex  neurotransmitter reuptake  glutamatergic synapse  integral component of presynaptic membrane  transport across blood-brain barrier  transport across blood-brain barrier  cysteine transmembrane transport  
Ontology : EGO-EBIL-glutamate transmembrane transporter activity  high-affinity glutamate transmembrane transporter activity  protein binding  plasma membrane  integral component of plasma membrane  glutathione biosynthetic process  ion transport  neurotransmitter transport  chemical synaptic transmission  visual behavior  response to wounding  cell surface  multicellular organism aging  glutamate:sodium symporter activity  L-glutamate transmembrane transport  membrane  telencephalon development  adult behavior  axolemma  cellular response to extracellular stimulus  vesicle  cysteine transmembrane transporter activity  multicellular organism growth  response to drug  response to amino acid  cell body  neuron projection terminus  membrane raft  membrane raft  positive regulation of glucose import  metal ion binding  protein homotrimerization  transepithelial transport  L-aspartate transmembrane transport  D-aspartate import across plasma membrane  cellular response to cocaine  astrocyte projection  L-glutamate import across plasma membrane  L-glutamate import across plasma membrane  membrane protein complex  membrane protein complex  neurotransmitter reuptake  glutamatergic synapse  integral component of presynaptic membrane  transport across blood-brain barrier  transport across blood-brain barrier  cysteine transmembrane transport  
Pathways : KEGGGlutamatergic synapse    Amyotrophic lateral sclerosis (ALS)   
NDEx NetworkSLC1A2
Atlas of Cancer Signalling NetworkSLC1A2
Wikipedia pathwaysSLC1A2
Orthology - Evolution
OrthoDB6506
GeneTree (enSembl)ENSG00000110436
Phylogenetic Trees/Animal Genes : TreeFamSLC1A2
Homologs : HomoloGeneSLC1A2
Homology/Alignments : Family Browser (UCSC)SLC1A2
Gene fusions - Rearrangements
Fusion : QuiverSLC1A2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC1A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC1A2
dbVarSLC1A2
ClinVarSLC1A2
MonarchSLC1A2
1000_GenomesSLC1A2 
Exome Variant ServerSLC1A2
GNOMAD BrowserENSG00000110436
Varsome BrowserSLC1A2
ACMGSLC1A2 variants
VarityP43004
Genomic Variants (DGV)SLC1A2 [DGVbeta]
DECIPHERSLC1A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC1A2 
Mutations
ICGC Data PortalSLC1A2 
TCGA Data PortalSLC1A2 
Broad Tumor PortalSLC1A2
OASIS PortalSLC1A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC1A2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSLC1A2
Mutations and Diseases : HGMDSLC1A2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSLC1A2
DgiDB (Drug Gene Interaction Database)SLC1A2
DoCM (Curated mutations)SLC1A2
CIViC (Clinical Interpretations of Variants in Cancer)SLC1A2
Cancer3DSLC1A2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600300    617105   
Orphanet
DisGeNETSLC1A2
MedgenSLC1A2
Genetic Testing Registry SLC1A2
NextProtP43004 [Medical]
GENETestsSLC1A2
Target ValidationSLC1A2
Huge Navigator SLC1A2 [HugePedia]
ClinGenSLC1A2
Clinical trials, drugs, therapy
MyCancerGenomeSLC1A2
Protein Interactions : CTDSLC1A2
Pharm GKB GenePA35827
PharosP43004
Clinical trialSLC1A2
Miscellaneous
canSAR (ICR)SLC1A2
HarmonizomeSLC1A2
DataMed IndexSLC1A2
Probes
Litterature
PubMed162 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSLC1A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:31:26 CEST 2021

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