SLC20A1 (solute carrier family 20 member 1)

2003-02-01  

Identity

HGNC
LOCATION
2q14.1
LOCUSID
ALIAS
GLVR1,Glvr-1,PIT1,PiT-1
FUSION GENES

Other Information

Locus ID:

NCBI: 6574
MIM: 137570
HGNC: 10946
Ensembl: ENSG00000144136

Variants:

dbSNP: 6574
ClinVar: 6574
TCGA: ENSG00000144136
COSMIC: SLC20A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144136ENST00000272542Q8WUM9
ENSG00000144136ENST00000272542A7LNJ1
ENSG00000144136ENST00000413135H7C3Q9
ENSG00000144136ENST00000423633H7BZY1
ENSG00000144136ENST00000433924H7BZK4
ENSG00000144136ENST00000456264H7C227

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Sodium-coupled phosphate cotransportersREACTOMER-HSA-427652

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
165279912006Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification.138
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
197266922009Identification of a novel function of PiT1 critical for cell proliferation and independent of its phosphate transport activity.34
174946322007Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements.26
156410672005Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes.19
208177332010Identification of a novel transport-independent function of PiT1/SLC20A1 in the regulation of TNF-induced apoptosis.19
120975822002Reassessing the role of region A in Pit1-mediated viral entry.17
167905042006Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.15
122050902002Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function.14
215861102011Mapping of the minimal inorganic phosphate transporting unit of human PiT2 suggests a structure universal to PiT-related proteins from all kingdoms of life.14

Citation

Dessen P

SLC20A1 (solute carrier family 20 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42314/slc20a1