Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SLC22A2 (solute carrier family 22 member 2)

Identity

Alias (NCBI)3-Oct
HGNC (Hugo) SLC22A2
HGNC Alias symb4-Oct
HGNC Alias nameorganic cation transporter 2
HGNC Previous namesolute carrier family 22 (organic cation transporter), member 2
LocusID (NCBI) 6582
Atlas_Id 46202
Location 6q25.3  [Link to chromosome band 6q25]
Location_base_pair Starts at 160216755 and ends at 160258821 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Testis: Spermatocytic seminoma

External links

Nomenclature
HGNC (Hugo)SLC22A2   10966
Cards
Entrez_Gene (NCBI)SLC22A2    solute carrier family 22 member 2
Aliases3-Oct
GeneCards (Weizmann)SLC22A2
Ensembl hg19 (Hinxton)ENSG00000112499 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112499 [Gene_View]  ENSG00000112499 [Sequence]  chr6:160216755-160258821 [Contig_View]  SLC22A2 [Vega]
ICGC DataPortalENSG00000112499
TCGA cBioPortalSLC22A2
AceView (NCBI)SLC22A2
Genatlas (Paris)SLC22A2
SOURCE (Princeton)SLC22A2
Genetics Home Reference (NIH)SLC22A2
Genomic and cartography
GoldenPath hg38 (UCSC)SLC22A2  -     chr6:160216755-160258821 -  6q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC22A2  -     6q25.3   [Description]    (hg19-Feb_2009)
GoldenPathSLC22A2 - 6q25.3 [CytoView hg19]  SLC22A2 - 6q25.3 [CytoView hg38]
ImmunoBaseENSG00000112499
genome Data Viewer NCBISLC22A2 [Mapview hg19]  
OMIM602608   
Gene and transcription
Genbank (Entrez)AB075951 AK290787 BC030978 BC039899 X98333
RefSeq transcript (Entrez)NM_003058 NM_153191
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLC22A2
Alternative Splicing GalleryENSG00000112499
Gene ExpressionSLC22A2 [ NCBI-GEO ]   SLC22A2 [ EBI - ARRAY_EXPRESS ]   SLC22A2 [ SEEK ]   SLC22A2 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC22A2 [ Firebrowse - Broad ]
GenevisibleExpression of SLC22A2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6582
GTEX Portal (Tissue expression)SLC22A2
Human Protein AtlasENSG00000112499-SLC22A2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15244   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15244  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15244
Splice isoforms : SwissVarO15244
PhosPhoSitePlusO15244
Domaine pattern : Prosite (Expaxy)MFS (PS50850)    SUGAR_TRANSPORT_1 (PS00216)   
Domains : Interpro (EBI)MFS_dom    MFS_sugar_transport-like    MFS_trans_sf    Orgcat_transp/SVOP    Sugar_transporter_CS   
Domain families : Pfam (Sanger)Sugar_tr (PF00083)   
Domain families : Pfam (NCBI)pfam00083   
Conserved Domain (NCBI)SLC22A2
Blocks (Seattle)SLC22A2
SuperfamilyO15244
Human Protein Atlas [tissue]ENSG00000112499-SLC22A2 [tissue]
Peptide AtlasO15244
HPRD04008
IPIIPI00017625   IPI00448803   IPI00885027   IPI00902459   
Protein Interaction databases
DIP (DOE-UCLA)O15244
IntAct (EBI)O15244
BioGRIDSLC22A2
STRING (EMBL)SLC22A2
ZODIACSLC22A2
Ontologies - Pathways
QuickGOO15244
Ontology : AmiGOplasma membrane  integral component of plasma membrane  drug transmembrane transport  neurotransmitter secretion  body fluid secretion  organic cation transmembrane transporter activity  organic cation transmembrane transporter activity  organic cation transport  organic cation transport  membrane  neurotransmitter biosynthetic process  extracellular exosome  presynapse  
Ontology : EGO-EBIplasma membrane  integral component of plasma membrane  drug transmembrane transport  neurotransmitter secretion  body fluid secretion  organic cation transmembrane transporter activity  organic cation transmembrane transporter activity  organic cation transport  organic cation transport  membrane  neurotransmitter biosynthetic process  extracellular exosome  presynapse  
NDEx NetworkSLC22A2
Atlas of Cancer Signalling NetworkSLC22A2
Wikipedia pathwaysSLC22A2
Orthology - Evolution
OrthoDB6582
GeneTree (enSembl)ENSG00000112499
Phylogenetic Trees/Animal Genes : TreeFamSLC22A2
HOGENOMO15244
Homologs : HomoloGeneSLC22A2
Homology/Alignments : Family Browser (UCSC)SLC22A2
Gene fusions - Rearrangements
Fusion : QuiverSLC22A2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC22A2 [hg38]
dbVarSLC22A2
ClinVarSLC22A2
MonarchSLC22A2
1000_GenomesSLC22A2 
Exome Variant ServerSLC22A2
GNOMAD BrowserENSG00000112499
Varsome BrowserSLC22A2
Genomic Variants (DGV)SLC22A2 [DGVbeta]
DECIPHERSLC22A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC22A2 
Mutations
ICGC Data PortalSLC22A2 
TCGA Data PortalSLC22A2 
Broad Tumor PortalSLC22A2
OASIS PortalSLC22A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC22A2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSLC22A2
Mutations and Diseases : HGMDSLC22A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC22A2
DgiDB (Drug Gene Interaction Database)SLC22A2
DoCM (Curated mutations)SLC22A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC22A2 (select a term)
intoGenSLC22A2
Cancer3DSLC22A2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602608   
Orphanet
DisGeNETSLC22A2
MedgenSLC22A2
Genetic Testing Registry SLC22A2
NextProtO15244 [Medical]
GENETestsSLC22A2
Target ValidationSLC22A2
Huge Navigator SLC22A2 [HugePedia]
ClinGenSLC22A2
Clinical trials, drugs, therapy
MyCancerGenomeSLC22A2
Protein Interactions : CTD
Pharm GKB GenePA331
Pharm GKB PathwaysPA165860384   PA165948259   
PharosO15244
Clinical trialSLC22A2
Miscellaneous
canSAR (ICR)SLC22A2 (select the gene name)
HarmonizomeSLC22A2
DataMed IndexSLC22A2
Probes
Litterature
PubMed113 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSLC22A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:37:36 CET 2021
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