SLC22A2 (solute carrier family 22 member 2)

2007-02-01 Affiliation

Identity

HGNC

SLC22A2

LOCATION

6q25.3

LOCUSID

6582

ALIAS

3-Oct

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6582
MIM: 602608
HGNC: 10966
Ensembl: ENSG00000112499

Variants:

dbSNP: 6582
ClinVar: 6582
TCGA: ENSG00000112499
COSMIC: SLC22A2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000112499	ENST00000366952	Q5T7Q5
ENSG00000112499	ENST00000366953	O15244

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Choline metabolism in cancer	KEGG	hsa05231
Choline metabolism in cancer	KEGG	ko05231
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Release Cycle	REACTOME	R-HSA-112310
Norepinephrine Neurotransmitter Release Cycle	REACTOME	R-HSA-181430
Neurotransmitter Clearance In The Synaptic Cleft	REACTOME	R-HSA-112311
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366
Na+/Cl- dependent neurotransmitter transporters	REACTOME	R-HSA-442660
Organic cation/anion/zwitterion transport	REACTOME	R-HSA-549132
Organic cation transport	REACTOME	R-HSA-549127
Metabolism	REACTOME	R-HSA-1430728
Abacavir transport and metabolism	REACTOME	R-HSA-2161522
Abacavir transmembrane transport	REACTOME	R-HSA-2161517

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10323	l-tryptophan	Chemical	ClinicalAnnotation	associated	PK		22590580
PA130620651	anthracyclines and related substances	Chemical	ClinicalAnnotation	associated		PD	21900104, 23441093
PA162263534	Ototoxicity	Disease	ClinicalAnnotation	associated		PD	25823781, 27457817, 28448657
PA164713176	Platinum compounds	Chemical	ClinicalAnnotation	associated		PD
PA166123389	fampridine	Chemical	LabelAnnotation, Literature, MultilinkAnnotation	associated			24433361
PA166123756	creatinine clearance	Disease	MultilinkAnnotation	associated			22223530
PA443622	Carcinoma, Non-Small-Cell Lung	Disease	ClinicalAnnotation	associated		PD
PA445062	Neoplasms	Disease	ClinicalAnnotation	associated	PK	PD	21900104, 21902499, 23441093
PA449014	cisplatin	Chemical	ClinicalAnnotation, MultilinkAnnotation	associated	PK	PD	21902499, 22223530, 25823781, 27457817, 28448657
PA450163	lamivudine	Chemical	Pathway	associated
PA450395	metformin	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway	associated	PK		22722338, 23417334, 24624919, 25939711

References

Pubmed ID	Year	Title	Citations
20383146	2010	New loci associated with kidney function and chronic kidney disease.	337
19625999	2009	Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity.	94
16951202	2006	Organic cation transporters are determinants of oxaliplatin cytotoxicity.	93
20682687	2010	Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.	88
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16314463	2005	Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2.	78
23424657	2013	Embryonic stem cells markers SOX2, OCT4 and Nanog expression and their correlations with epithelial-mesenchymal transition in nasopharyngeal carcinoma.	75
19536068	2009	The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.	68
18401339	2008	Genetic variants of the organic cation transporter 2 influence the disposition of metformin.	60
18551044	2008	OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine.	59

Citation

Dessen P

SLC22A2 (solute carrier family 22 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46202/slc22a2