Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6583
MIM: 604190
HGNC: 10968
Ensembl: ENSG00000197208
Variants:
dbSNP: 6583
ClinVar: 6583
TCGA: ENSG00000197208
COSMIC: SLC22A4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000197208 | ENST00000200652 | Q9H015 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10804 | imatinib | Chemical | ClinicalAnnotation | associated | PD | 22875622, 23127916 | |
| PA151958383 | Gastrointestinal Stromal Tumors | Disease | ClinicalAnnotation | associated | PD | 22875622, 23127916 | |
| PA443890 | Diabetes Mellitus, Type 2 | Disease | VariantAnnotation | not associated | PD | ||
| PA446171 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | Disease | ClinicalAnnotation | associated | PD | 22875622, 23127916 | |
| PA450395 | metformin | Chemical | VariantAnnotation | not associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38092232 | 2024 | OCTN1 (SLC22A4) displays two different transport pathways for organic cations or zwitterions. | 2 |
| 38092232 | 2024 | OCTN1 (SLC22A4) displays two different transport pathways for organic cations or zwitterions. | 2 |
| 38112574 | 2023 | Investigating the ID3/SLC22A4 as immune-related signatures in ischemic stroke. | 0 |
| 38112574 | 2023 | Investigating the ID3/SLC22A4 as immune-related signatures in ischemic stroke. | 0 |
| 34958679 | 2022 | The ergothioneine transporter (ETT): substrates and locations, an inventory. | 16 |
| 34958679 | 2022 | The ergothioneine transporter (ETT): substrates and locations, an inventory. | 16 |
| 32905646 | 2021 | DNA Methylation-Based Epigenetic Repression of SLC22A4 Promotes Resistance to Cytarabine in Acute Myeloid Leukemia. | 10 |
| 32964310 | 2021 | Tooth loss and adiposity: possible role of carnitine transporter (OCTN1/2) polymorphisms in women but not in men. | 1 |
| 32905646 | 2021 | DNA Methylation-Based Epigenetic Repression of SLC22A4 Promotes Resistance to Cytarabine in Acute Myeloid Leukemia. | 10 |
| 32964310 | 2021 | Tooth loss and adiposity: possible role of carnitine transporter (OCTN1/2) polymorphisms in women but not in men. | 1 |
| 31591905 | 2020 | LPS-induced inflammation delays the transportation of ASP(+) due to down-regulation of OCTN1/2 in alveolar epithelial cells. | 6 |
| 32149389 | 2020 | Cetirizine Reduces Gabapentin Plasma Concentrations and Effect: Role of Renal Drug Transporters for Organic Cations. | 2 |
| 31591905 | 2020 | LPS-induced inflammation delays the transportation of ASP(+) due to down-regulation of OCTN1/2 in alveolar epithelial cells. | 6 |
| 32149389 | 2020 | Cetirizine Reduces Gabapentin Plasma Concentrations and Effect: Role of Renal Drug Transporters for Organic Cations. | 2 |
| 30929922 | 2019 | Specificity of the ergothioneine transporter natively expressed in HeLa cells. | 13 |
Citation
Dessen P
SLC22A4 (solute carrier family 22 member 4)
Atlas Genet Cytogenet Oncol Haematol. 2011-07-01
Online version: http://atlasgeneticsoncology.org/gene/52522/slc22a4
