SLC22A7 (solute carrier family 22 member 7)

2015-02-01  

Identity

HGNC
SLC22A7
LOCATION
6p21.1
LOCUSID
10864
ALIAS
NLT,OAT2,hOAT11

Other Information

Locus ID:

NCBI: 10864
MIM: 604995
HGNC: 10971
Ensembl: ENSG00000137204

Variants:

dbSNP: 10864
ClinVar: 10864
TCGA: ENSG00000137204
COSMIC: SLC22A7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137204ENST00000372574Q9Y694
ENSG00000137204ENST00000372585Q9Y694
ENSG00000137204ENST00000372589Q9Y694
ENSG00000137204ENST00000436107X6RDF7
ENSG00000137204ENST00000449231Q5T051
ENSG00000137204ENST00000451757Q5T047

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Organic cation/anion/zwitterion transportREACTOMER-HSA-549132
Organic anion transportREACTOMER-HSA-561048

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443899DiarrheaDiseaseClinicalAnnotationassociatedPD28347776
PA443937Drug ToxicityDiseaseClinicalAnnotationassociatedPD28347776
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD28347776
PA448771capecitabineChemicalClinicalAnnotationassociatedPD28347776
PA451954zidovudineChemicalPathwayassociated22960662

References

Pubmed IDYearTitleCitations
246468602014Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat.43
182161832008Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP.28
262306412015Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children.21
221906962012Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs.14
214469182011OAT2 catalyses efflux of glutamate and uptake of orotic acid.13
259047622015Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression.13
118556802002Human organic anion transporters mediate the transport of tetracycline.11
235433122014Mitochondrial metabolism in the noncancerous liver determine the occurrence of hepatocellular carcinoma: a prospective study.5
283715062017Population-Specific Resequencing Associates the ATP-Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand Māori and Pacific Men.5
292441912018The role of OAT2 (SLC22A7) in the cyclic nucleotide biokinetics of human erythrocytes.5

Citation

Dessen P

SLC22A7 (solute carrier family 22 member 7)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54990/slc22a7