SLC22A8 (solute carrier family 22 member 8)

2015-04-01  

Identity

HGNC
SLC22A8
LOCATION
11q12.3
LOCUSID
9376
ALIAS
OAT3

Other Information

Locus ID:

NCBI: 9376
MIM: 607581
HGNC: 10972
Ensembl: ENSG00000149452

Variants:

dbSNP: 9376
ClinVar: 9376
TCGA: ENSG00000149452
COSMIC: SLC22A8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149452ENST00000311438H7BXN9
ENSG00000149452ENST00000336232Q8TCC7
ENSG00000149452ENST00000430500Q8TCC7
ENSG00000149452ENST00000535878Q8TCC7
ENSG00000149452ENST00000545207Q8TCC7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Organic cation/anion/zwitterion transportREACTOMER-HSA-549132
Organic anion transportREACTOMER-HSA-561048

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA133950441hmg coa reductase inhibitorsChemicalPathwayassociated
PA166163418rucaparibChemicalLabelAnnotationassociated
PA448852cefotaximeChemicalClinicalAnnotationassociatedPK23649425
PA450428methotrexateChemicalPathwayassociated21317831, 25502615
PA451089pravastatinChemicalPathwayassociated
PA451954zidovudineChemicalPathwayassociated22960662

References

Pubmed IDYearTitleCitations
128113652003Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.63
128113652003Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.63
199566352009Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.27
162915762006The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics.25
162915762006The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics.25
167939322006Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1alpha/beta and DNA methylation.24
198786712010Angiotensin II inhibits activity of human organic anion transporter 3 through activation of protein kinase Calpha: accelerating endocytosis of the transporter.21
175789012007Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices.19
221085722012Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3.19
166489422006Analyses of 5' regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3).13

Citation

Dessen P

SLC22A8 (solute carrier family 22 member 8)

Atlas Genet Cytogenet Oncol Haematol. 2015-04-01

Online version: http://atlasgeneticsoncology.org/gene/55174/slc22a8