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SLC23A2 (solute carrier family 23 member 2)

Identity

Alias_namesSLC23A1
solute carrier family 23 (nucleobase transporters), member 1
solute carrier family 23 (ascorbic acid transporter), member 2
Alias_symbol (synonym)SVCT2
KIAA0238
YSPL2
Other aliasNBTL1
hSVCT2
HGNC (Hugo) SLC23A2
LocusID (NCBI) 9962
Atlas_Id 50440
Location 20p13  [Link to chromosome band 20p13]
Location_base_pair Starts at 4852356 and ends at 5001499 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FLOT2 (17q11.2) / SLC23A2 (20p13)RPL36 (19p13.3) / SLC23A2 (20p13)SLC23A2 (20p13) / NDUFS2 (1q23.3)
SLC23A2 (20p13) / PHKB (16q12.1)SLC23A2 (20p13) / SLC23A2 (20p13)UBC (12q24.31) / SLC23A2 (20p13)
SLC23A2 20p13 / PHKB 16q12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC23A2   10973
Cards
Entrez_Gene (NCBI)SLC23A2  9962  solute carrier family 23 member 2
AliasesNBTL1; SLC23A1; SVCT2; YSPL2; 
hSVCT2
GeneCards (Weizmann)SLC23A2
Ensembl hg19 (Hinxton)ENSG00000089057 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000089057 [Gene_View]  chr20:4852356-5001499 [Contig_View]  SLC23A2 [Vega]
ICGC DataPortalENSG00000089057
TCGA cBioPortalSLC23A2
AceView (NCBI)SLC23A2
Genatlas (Paris)SLC23A2
WikiGenes9962
SOURCE (Princeton)SLC23A2
Genetics Home Reference (NIH)SLC23A2
Genomic and cartography
GoldenPath hg38 (UCSC)SLC23A2  -     chr20:4852356-5001499 -  20p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC23A2  -     20p13   [Description]    (hg19-Feb_2009)
EnsemblSLC23A2 - 20p13 [CytoView hg19]  SLC23A2 - 20p13 [CytoView hg38]
Mapping of homologs : NCBISLC23A2 [Mapview hg19]  SLC23A2 [Mapview hg38]
OMIM603791   
Gene and transcription
Genbank (Entrez)AB075494 AF058319 AF092511 AF164142 AI742576
RefSeq transcript (Entrez)NM_005116 NM_203327
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLC23A2
Cluster EST : UnigeneHs.516866 [ NCBI ]
CGAP (NCI)Hs.516866
Alternative Splicing GalleryENSG00000089057
Gene ExpressionSLC23A2 [ NCBI-GEO ]   SLC23A2 [ EBI - ARRAY_EXPRESS ]   SLC23A2 [ SEEK ]   SLC23A2 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC23A2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9962
GTEX Portal (Tissue expression)SLC23A2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UGH3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UGH3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UGH3
Splice isoforms : SwissVarQ9UGH3
PhosPhoSitePlusQ9UGH3
Domaine pattern : Prosite (Expaxy)XANTH_URACIL_PERMASE (PS01116)   
Domains : Interpro (EBI)SlC23A2    Xan_ur_permease    Xant/urac/vitC   
Domain families : Pfam (Sanger)Xan_ur_permease (PF00860)   
Domain families : Pfam (NCBI)pfam00860   
Conserved Domain (NCBI)SLC23A2
DMDM Disease mutations9962
Blocks (Seattle)SLC23A2
SuperfamilyQ9UGH3
Human Protein AtlasENSG00000089057
Peptide AtlasQ9UGH3
HPRD04811
IPIIPI00552917   IPI00295774   
Protein Interaction databases
DIP (DOE-UCLA)Q9UGH3
IntAct (EBI)Q9UGH3
FunCoupENSG00000089057
BioGRIDSLC23A2
STRING (EMBL)SLC23A2
ZODIACSLC23A2
Ontologies - Pathways
QuickGOQ9UGH3
Ontology : AmiGOcytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  nucleobase-containing compound metabolic process  sodium ion transport  response to oxidative stress  L-ascorbate:sodium symporter activity  sodium-dependent multivitamin transmembrane transporter activity  basal plasma membrane  nucleobase transmembrane transporter activity  L-ascorbic acid transporter activity  L-ascorbic acid transporter activity  nucleobase transport  L-ascorbic acid transport  molecular hydrogen transport  membrane  integral component of membrane  basolateral plasma membrane  apical plasma membrane  L-ascorbic acid metabolic process  L-ascorbic acid metabolic process  vitamin transmembrane transport  sodium-dependent L-ascorbate transmembrane transporter activity  transepithelial L-ascorbic acid transport  carboxylic acid transmembrane transport  
Ontology : EGO-EBIcytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  nucleobase-containing compound metabolic process  sodium ion transport  response to oxidative stress  L-ascorbate:sodium symporter activity  sodium-dependent multivitamin transmembrane transporter activity  basal plasma membrane  nucleobase transmembrane transporter activity  L-ascorbic acid transporter activity  L-ascorbic acid transporter activity  nucleobase transport  L-ascorbic acid transport  molecular hydrogen transport  membrane  integral component of membrane  basolateral plasma membrane  apical plasma membrane  L-ascorbic acid metabolic process  L-ascorbic acid metabolic process  vitamin transmembrane transport  sodium-dependent L-ascorbate transmembrane transporter activity  transepithelial L-ascorbic acid transport  carboxylic acid transmembrane transport  
Pathways : BIOCARTAVitamin C in the Brain [Genes]   
NDEx NetworkSLC23A2
Atlas of Cancer Signalling NetworkSLC23A2
Wikipedia pathwaysSLC23A2
Orthology - Evolution
OrthoDB9962
GeneTree (enSembl)ENSG00000089057
Phylogenetic Trees/Animal Genes : TreeFamSLC23A2
HOVERGENQ9UGH3
HOGENOMQ9UGH3
Homologs : HomoloGeneSLC23A2
Homology/Alignments : Family Browser (UCSC)SLC23A2
Gene fusions - Rearrangements
Fusion : MitelmanSLC23A2/PHKB [20p13/16q12.1]  
Fusion: TCGASLC23A2 20p13 PHKB 16q12.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC23A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC23A2
dbVarSLC23A2
ClinVarSLC23A2
1000_GenomesSLC23A2 
Exome Variant ServerSLC23A2
ExAC (Exome Aggregation Consortium)SLC23A2 (select the gene name)
Genetic variants : HAPMAP9962
Genomic Variants (DGV)SLC23A2 [DGVbeta]
DECIPHERSLC23A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC23A2 
Mutations
ICGC Data PortalSLC23A2 
TCGA Data PortalSLC23A2 
Broad Tumor PortalSLC23A2
OASIS PortalSLC23A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC23A2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC23A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC23A2
DgiDB (Drug Gene Interaction Database)SLC23A2
DoCM (Curated mutations)SLC23A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC23A2 (select a term)
intoGenSLC23A2
Cancer3DSLC23A2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603791   
Orphanet
MedgenSLC23A2
Genetic Testing Registry SLC23A2
NextProtQ9UGH3 [Medical]
TSGene9962
GENETestsSLC23A2
Target ValidationSLC23A2
Huge Navigator SLC23A2 [HugePedia]
snp3D : Map Gene to Disease9962
BioCentury BCIQSLC23A2
ClinGenSLC23A2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9962
Chemical/Pharm GKB GenePA35849
Clinical trialSLC23A2
Miscellaneous
canSAR (ICR)SLC23A2 (select the gene name)
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC23A2
EVEXSLC23A2
GoPubMedSLC23A2
iHOPSLC23A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:07:30 CEST 2017

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