SLC25A10 (solute carrier family 25 member 10)

2014-11-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
DIC,MTDPS19
FUSION GENES

Other Information

Locus ID:

NCBI: 1468
MIM: 606794
HGNC: 10980
Ensembl: ENSG00000183048

Variants:

dbSNP: 1468
ClinVar: 1468
TCGA: ENSG00000183048
COSMIC: SLC25A10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183048ENST00000331531Q9UBX3
ENSG00000183048ENST00000331531A0A0S2Z3G3
ENSG00000183048ENST00000350690Q9UBX3
ENSG00000183048ENST00000350690A0A0S2Z382
ENSG00000183048ENST00000545862F6RGN5
ENSG00000183048ENST00000574129I3L3N9
ENSG00000183048ENST00000574884I3L1E8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Proximal tubule bicarbonate reclamationKEGGko04964
Proximal tubule bicarbonate reclamationKEGGhsa04964
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Organic anion transportersREACTOMER-HSA-428643
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GluconeogenesisREACTOMER-HSA-70263
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Sulfur amino acid metabolismREACTOMER-HSA-1614635
Degradation of cysteine and homocysteineREACTOMER-HSA-1614558
Sulfide oxidation to sulfateREACTOMER-HSA-1614517

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
232661872013The mitochondrial transporter family SLC25: identification, properties and physiopathology.159
215555182011The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.60
160271202005Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis.24
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
302051672018Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia.10
257972532015The mitochondrial carrier SLC25A10 regulates cancer cell growth.7
285705792017Global transcriptome profiling identifies KLF15 and SLC25A10 as modifiers of adipocytes insulin sensitivity in obese women.7
292118462018SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency.6
309434272019The circadian protein CLOCK regulates cell metabolism via the mitochondrial carrier SLC25A10.3

Citation

Dessen P

SLC25A10 (solute carrier family 25 member 10)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73334/slc25a10