SLC25A11 (solute carrier family 25 member 11)

2019-08-01  

Identity

HGNC
LOCATION
17p13.2
LOCUSID
ALIAS
OGC,PGL6,SLC20A4

Other Information

Locus ID:

NCBI: 8402
MIM: 604165
HGNC: 10981
Ensembl: ENSG00000108528

Variants:

dbSNP: 8402
ClinVar: 8402
TCGA: ENSG00000108528
COSMIC: SLC25A11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108528ENST00000225665Q02978
ENSG00000108528ENST00000225665Q6IBH0
ENSG00000108528ENST00000544061Q02978
ENSG00000108528ENST00000576951I3L1P8

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GluconeogenesisREACTOMER-HSA-70263

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
232661872013The mitochondrial transporter family SLC25: identification, properties and physiopathology.159
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
129395962003Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion.34
169207062006Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier.21
294316362018Germline Mutations in the Mitochondrial 2-Oxoglutarate/Malate Carrier SLC25A11 Gene Confer a Predisposition to Metastatic Paragangliomas.21
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
282422972017Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments.14
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
214484542011MISC-1/OGC links mitochondrial metabolism, apoptosis and insulin secretion.8
230540772013The mitochondrial oxoglutarate carrier: from identification to mechanism.8

Citation

Dessen P

SLC25A11 (solute carrier family 25 member 11)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58116/slc25a11