SLC26A3 (solute carrier family 26 member 3)

2003-02-01  

Identity

HGNC
LOCATION
7q22.3
LOCUSID
ALIAS
CLD,DRA

Other Information

Locus ID:

NCBI: 1811
MIM: 126650
HGNC: 3018
Ensembl: ENSG00000091138

Variants:

dbSNP: 1811
ClinVar: 1811
TCGA: ENSG00000091138
COSMIC: SLC26A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000091138ENST00000340010P40879
ENSG00000091138ENST00000379083F8WBL6
ENSG00000091138ENST00000453332C9JFJ2

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Multifunctional anion exchangersREACTOMER-HSA-427601

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
387045452024Congenital chloride diarrhoea in a Chinese infant with a compound heterozygous SLC26A3 mutation.0
387045452024Congenital chloride diarrhoea in a Chinese infant with a compound heterozygous SLC26A3 mutation.0
371544942023SLC26A3 (DRA) is stimulated in a synergistic, intracellular Ca(2+)-dependent manner by cAMP and ATP in intestinal epithelial cells.1
371544942023SLC26A3 (DRA) is stimulated in a synergistic, intracellular Ca(2+)-dependent manner by cAMP and ATP in intestinal epithelial cells.1
360842192022The rs12532734 Polymorphism Near the Solute Carrier 26A3 Gene Locus Is Associated With Gallstone Disease in Children.0
360842192022The rs12532734 Polymorphism Near the Solute Carrier 26A3 Gene Locus Is Associated With Gallstone Disease in Children.0
329894682021Slc26a3 (DRA) in the Gut: Expression, Function, Regulation, Role in Infectious Diarrhea and Inflammatory Bowel Disease.17
331897002021A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity.38
335143052021Segmental differences in Slc26a3-dependent Cl(-) absorption and HCO(3)(-) secretion in the mouse large intestine in vitro in Ussing chambers.5
329894682021Slc26a3 (DRA) in the Gut: Expression, Function, Regulation, Role in Infectious Diarrhea and Inflammatory Bowel Disease.17
331897002021A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity.38
335143052021Segmental differences in Slc26a3-dependent Cl(-) absorption and HCO(3)(-) secretion in the mouse large intestine in vitro in Ussing chambers.5
316343912020All-trans Retinoic Acid Counteracts Diarrhea and Inhibition of Downregulated in Adenoma Expression in Gut Inflammation.2
321160232020SNX27 regulates DRA activity and mediates its direct recycling by PDZ-interaction in early endosomes at the apical pole of Caco2 cells.4
316343912020All-trans Retinoic Acid Counteracts Diarrhea and Inhibition of Downregulated in Adenoma Expression in Gut Inflammation.2

Citation

Dessen P

SLC26A3 (solute carrier family 26 member 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42318/slc26a3