SLC26A3 (solute carrier family 26 member 3)

2003-02-01  

Identity

HGNC
SLC26A3
LOCATION
7q22.3
LOCUSID
1811
ALIAS
CLD,DRA

Other Information

Locus ID:

NCBI: 1811
MIM: 126650
HGNC: 3018
Ensembl: ENSG00000091138

Variants:

dbSNP: 1811
ClinVar: 1811
TCGA: ENSG00000091138
COSMIC: SLC26A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000091138ENST00000340010P40879
ENSG00000091138ENST00000379083F8WBL6
ENSG00000091138ENST00000453332C9JFJ2

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Multifunctional anion exchangersREACTOMER-HSA-427601

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199155732009A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.81
199155732009A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.81
166066872006Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6.65
118347422002Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.54
126519232003Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes.53
123698222002The down regulated in adenoma (dra) gene product binds to the second PDZ domain of the NHE3 kinase A regulatory protein (E3KARP), potentially linking intestinal Cl-/HCO3- exchange to Na+/H+ exchange.31
213948282011Update on SLC26A3 mutations in congenital chloride diarrhea.31
164212162006Expression of SLC26A3, CFTR and NHE3 in the human male reproductive tract: role in male subfertility caused by congenital chloride diarrhoea.28
200445112010Lactobacillus acidophilus stimulates the expression of SLC26A3 via a transcriptional mechanism.28
177618372007Molecular cloning and promoter analysis of downregulated in adenoma (DRA).26

Citation

Dessen P

SLC26A3 (solute carrier family 26 member 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42318/slc26a3