SLC27A1 (solute carrier family 27 member 1)

2014-11-01 Affiliation

Identity

HGNC

SLC27A1

LOCATION

19p13.11

LOCUSID

376497

ALIAS

ACSVL5,FATP,FATP-1,FATP1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 376497
MIM: 600691
HGNC: 10995
Ensembl: ENSG00000130304

Variants:

dbSNP: 376497
ClinVar: 376497
TCGA: ENSG00000130304
COSMIC: SLC27A1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000130304	ENST00000252595	Q6PCB7
ENSG00000130304	ENST00000598424	Q6PCB7
ENSG00000130304	ENST00000599380	M0QXY2
ENSG00000130304	ENST00000599965	M0QZC9
ENSG00000130304	ENST00000600277	B7Z225
ENSG00000130304	ENST00000600297	B7Z225

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
PPAR signaling pathway	KEGG	ko03320
PPAR signaling pathway	KEGG	hsa03320
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of vitamins, nucleosides, and related molecules	REACTOME	R-HSA-425397
Transport of fatty acids	REACTOME	R-HSA-804914
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	REACTOME	R-HSA-400206
PPARA activates gene expression	REACTOME	R-HSA-1989781
Insulin resistance	KEGG	hsa04931

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
18660489	2008	Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.	26
20416077	2010	Identification of type 2 diabetes-associated combination of SNPs using support vector machine.	26
15897321	2005	Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells.	20
24120574	2014	Fatty acid transporters in skin development, function and disease.	17
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
15978856	2005	Lack of association between certain candidate gene polymorphisms and the metabolic syndrome.	9
12818409	2003	A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution.	8
12818409	2003	A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution.	8
20356843	2010	FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase.	8

Citation

Dessen P

SLC27A1 (solute carrier family 27 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73378/slc27a1