SLC27A2 (solute carrier family 27 member 2)

2021-06-01  

Identity

HGNC
LOCATION
15q21.2
LOCUSID
ALIAS
ACSVL1,FACVL1,FATP2,HsT17226,VLACS,VLCS,hFACVL1

Other Information

Locus ID:

NCBI: 11001
MIM: 603247
HGNC: 10996
Ensembl: ENSG00000140284

Variants:

dbSNP: 11001
ClinVar: 11001
TCGA: ENSG00000140284
COSMIC: SLC27A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140284ENST00000267842O14975
ENSG00000140284ENST00000380902O14975
ENSG00000140284ENST00000544960G3V1R7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
PPAR signaling pathwayKEGGhsa03320
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Peroxisomal lipid metabolismREACTOMER-HSA-390918
Alpha-oxidation of phytanateREACTOMER-HSA-389599
Bile acid and bile salt metabolismREACTOMER-HSA-194068
Synthesis of bile acids and bile saltsREACTOMER-HSA-192105
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterolREACTOMER-HSA-193368
Synthesis of bile acids and bile salts via 24-hydroxycholesterolREACTOMER-HSA-193775
Insulin resistanceKEGGhsa04931
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
179984372008Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.189
309963462019Fatty acid transport protein 2 reprograms neutrophils in cancer.37
220287932011The expression and function of fatty acid transport protein-2 and -4 in the murine placenta.24
217681002011Human fatty acid transport protein 2a/very long chain acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol.18
270167842016Protein expression of fatty acid transporter 2 is polarized to the trophoblast basal plasma membrane and increased in placentas from overweight/obese women.12
241133822013Overexpression of human fatty acid transport protein 2/very long chain acyl-CoA synthetase 1 (FATP2/Acsvl1) reveals distinct patterns of trafficking of exogenous fatty acids.11
209657182011Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).4
242776912014Influence of breastfeeding on blood-cell transcript-based biomarkers of health in children.3
262849752015Fatty acid transport protein-2 inhibitor Grassofermata/CB5 protects cells against lipid accumulation and toxicity.3

Citation

Dessen P

SLC27A2 (solute carrier family 27 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58301/slc27a2