SLC27A3 (solute carrier family 27 member 3)

2010-01-01  

Identity

HGNC
SLC27A3
LOCATION
1q21.3
LOCUSID
11000
ALIAS
ACSVL3,FATP3,VLCS-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11000
MIM: 604193
HGNC: 10997
Ensembl: ENSG00000143554

Variants:

dbSNP: 11000
ClinVar: 11000
TCGA: ENSG00000143554
COSMIC: SLC27A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143554ENST00000271857X6R3N0
ENSG00000143554ENST00000458027H7BZH4
ENSG00000143554ENST00000524676H0YDP0
ENSG00000143554ENST00000532853H0YDM5
ENSG00000143554ENST00000624995Q5K4L6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105
Synthesis of very long-chain fatty acyl-CoAsREACTOMER-HSA-75876
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
265485582015Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism.7
265485582015Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism.7
248939522014Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity.30
248939522014Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity.30
239360042013Very long-chain acyl-CoA synthetase 3: overexpression and growth dependence in lung cancer.15
239360042013Very long-chain acyl-CoA synthetase 3: overexpression and growth dependence in lung cancer.15
209657182011Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).4
209657182011Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).4
199201852009Acyl-CoA synthetase VL3 knockdown inhibits human glioma cell proliferation and tumorigenicity.28
199201852009Acyl-CoA synthetase VL3 knockdown inhibits human glioma cell proliferation and tumorigenicity.28

Citation

Dessen P

SLC27A3 (solute carrier family 27 member 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51287/slc27a3