SLC28A1 (solute carrier family 28 member 1)

2007-02-01  

Identity

HGNC
SLC28A1
LOCATION
15q25.3
LOCUSID
9154
ALIAS
CNT1,HCNT1,URCTU
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9154
MIM: 606207
HGNC: 11001
Ensembl: ENSG00000156222

Variants:

dbSNP: 9154
ClinVar: 9154
TCGA: ENSG00000156222
COSMIC: SLC28A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156222ENST00000286749O00337
ENSG00000156222ENST00000338602O00337
ENSG00000156222ENST00000394573O00337
ENSG00000156222ENST00000538177B7Z3L6

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membraneREACTOMER-HSA-83936

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130620651anthracyclines and related substancesChemicalClinicalAnnotationassociatedPD21900104, 23441093
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD18538445
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD21900104, 23441093
PA445113NeutropeniaDiseaseClinicalAnnotation, VariantAnnotationassociatedPD30889042
PA445218Pancreatic NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationassociatedPD30889042
PA449748gemcitabineChemicalClinicalAnnotation, Pathway, VariantAnnotationassociatedPD18538445, 25162786, 30889042
PA451954zidovudineChemicalPathwayassociated22960662

References

Pubmed IDYearTitleCitations
145813752003Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity.50
225806022013The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family.44
200287592010Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity.34
213433962011CNT1 expression influences proliferation and chemosensitivity in drug-resistant pancreatic cancer cells.33
206654882010Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer.27
190748852008Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.25
186356032008Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes.20
203925012010Contribution of adenosine related genes to the risk of depression with disturbed sleep.20
258904972015The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2.19
191391322009Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation.18

Citation

Dessen P

SLC28A1 (solute carrier family 28 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45889/slc28a1