SLC2A10 (solute carrier family 2 member 10)

2014-08-01  

Identity

HGNC
LOCATION
20q13.12
LOCUSID
ALIAS
ATORS,ATS,GLUT10
FUSION GENES

Other Information

Locus ID:

NCBI: 81031
MIM: 606145
HGNC: 13444
Ensembl: ENSG00000197496

Variants:

dbSNP: 81031
ClinVar: 81031
TCGA: ENSG00000197496
COSMIC: SLC2A10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197496ENST00000359271O95528
ENSG00000197496ENST00000486000A0A087WUH5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Facilitative Na+-independent glucose transportersREACTOMER-HSA-428790

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
165501712006Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome.90
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
250789642014Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index.23
128904772003Expression of Class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues.15
263768652015GLUT10 deficiency leads to oxidative stress and non-canonical αvβ3 integrin-mediated TGFβ signalling associated with extracellular matrix disarray in arterial tortuosity syndrome skin fibroblasts.15
271531852016Glucose transporter type 10-lacking in arterial tortuosity syndrome-facilitates dehydroascorbic acid transport.12
163366372005Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
165860672006Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population.8

Citation

Dessen P

SLC2A10 (solute carrier family 2 member 10)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54635/slc2a10