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SLC2A4 (solute carrier family 2 (facilitated glucose transporter), member 4)

Identity

Other namesGLUT4
HGNC (Hugo) SLC2A4
LocusID (NCBI) 6517
Atlas_Id 46491
Location 17p13.1
Location_base_pair Starts at 7185054 and ends at 7191367 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SLC2A4   11009
Cards
Entrez_Gene (NCBI)SLC2A4  6517  solute carrier family 2 (facilitated glucose transporter), member 4
GeneCards (Weizmann)SLC2A4
Ensembl hg19 (Hinxton)ENSG00000181856 [Gene_View]  chr17:7185054-7191367 [Contig_View]  SLC2A4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000181856 [Gene_View]  chr17:7185054-7191367 [Contig_View]  SLC2A4 [Vega]
ICGC DataPortalENSG00000181856
TCGA cBioPortalSLC2A4
AceView (NCBI)SLC2A4
Genatlas (Paris)SLC2A4
WikiGenes6517
SOURCE (Princeton)SLC2A4
Genomic and cartography
GoldenPath hg19 (UCSC)SLC2A4  -     chr17:7185054-7191367 +  17p13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SLC2A4  -     17p13.1   [Description]    (hg38-Dec_2013)
EnsemblSLC2A4 - 17p13.1 [CytoView hg19]  SLC2A4 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBISLC2A4 [Mapview hg19]  SLC2A4 [Mapview hg38]
OMIM138190   
Gene and transcription
Genbank (Entrez)AK300899 AK313372 AL521328 BC034387 BC069615
RefSeq transcript (Entrez)NM_001042
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_012127 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)SLC2A4
Cluster EST : UnigeneHs.380691 [ NCBI ]
CGAP (NCI)Hs.380691
Alternative Splicing : Fast-db (Paris)GSHG0012185
Alternative Splicing GalleryENSG00000181856
Gene ExpressionSLC2A4 [ NCBI-GEO ]     SLC2A4 [ SEEK ]   SLC2A4 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14672 (Uniprot)
NextProtP14672  [Medical]  [Publications]
With graphics : InterProP14672
Splice isoforms : SwissVarP14672 (Swissvar)
Domaine pattern : Prosite (Expaxy)MFS (PS50850)    SUGAR_TRANSPORT_1 (PS00216)    SUGAR_TRANSPORT_2 (PS00217)   
Domains : Interpro (EBI)Glc_transpt_4    MFS_dom    Sub_transporter    Sugar/inositol_transpt    Sugar_transporter_CS   
Related proteins : CluSTrP14672
Domain families : Pfam (Sanger)Sugar_tr (PF00083)   
Domain families : Pfam (NCBI)pfam00083   
DMDM Disease mutations6517
Blocks (Seattle)P14672
Human Protein AtlasENSG00000181856
Peptide AtlasP14672
HPRD00688
IPIIPI00027281   IPI01013958   IPI00795418   
Protein Interaction databases
DIP (DOE-UCLA)P14672
IntAct (EBI)P14672
FunCoupENSG00000181856
BioGRIDSLC2A4
IntegromeDBSLC2A4
STRING (EMBL)SLC2A4
ZODIACSLC2A4
Ontologies - Pathways
QuickGOP14672
Ontology : AmiGOsugar:proton symporter activity  glucose transmembrane transporter activity  protein binding  multivesicular body  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  coated pit  carbohydrate metabolic process  hexose transport  external side of plasma membrane  amylopectin biosynthetic process  endomembrane system  vesicle membrane  glucose transport  proton transport  membrane  clathrin-coated vesicle  trans-Golgi network transport vesicle  T-tubule  insulin-responsive compartment  insulin-responsive compartment  cellular response to insulin stimulus  hexose transmembrane transport  glucose homeostasis  small molecule metabolic process  membrane raft  response to ethanol  glucose import  glucose import  perinuclear region of cytoplasm  brown fat cell differentiation  D-glucose transmembrane transporter activity  transmembrane transport  membrane organization  extracellular exosome  cellular response to hypoxia  cellular response to osmotic stress  
Ontology : EGO-EBIsugar:proton symporter activity  glucose transmembrane transporter activity  protein binding  multivesicular body  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  coated pit  carbohydrate metabolic process  hexose transport  external side of plasma membrane  amylopectin biosynthetic process  endomembrane system  vesicle membrane  glucose transport  proton transport  membrane  clathrin-coated vesicle  trans-Golgi network transport vesicle  T-tubule  insulin-responsive compartment  insulin-responsive compartment  cellular response to insulin stimulus  hexose transmembrane transport  glucose homeostasis  small molecule metabolic process  membrane raft  response to ethanol  glucose import  glucose import  perinuclear region of cytoplasm  brown fat cell differentiation  D-glucose transmembrane transporter activity  transmembrane transport  membrane organization  extracellular exosome  cellular response to hypoxia  cellular response to osmotic stress  
Pathways : BIOCARTAGrowth Hormone Signaling Pathway [Genes]    Insulin Signaling Pathway [Genes]    Regulation of PGC-1a [Genes]   
Pathways : KEGGFoxO signaling pathway    Insulin signaling pathway    Adipocytokine signaling pathway    Type II diabetes mellitus   
Protein Interaction DatabaseSLC2A4
Atlas of Cancer Signalling NetworkSLC2A4
Wikipedia pathwaysSLC2A4
Gene fusion - Rearrangements
Fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerSLC2A4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC2A4
dbVarSLC2A4
ClinVarSLC2A4
1000_GenomesSLC2A4 
Exome Variant ServerSLC2A4
SNP (GeneSNP Utah)SLC2A4
SNP : HGBaseSLC2A4
Genetic variants : HAPMAPSLC2A4
Genomic Variants (DGV)SLC2A4 [DGVbeta]
Mutations
ICGC Data PortalSLC2A4 
TCGA Data PortalSLC2A4 
Tumor PortalSLC2A4
Somatic Mutations in Cancer : COSMICSLC2A4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
DoCM (Curated mutations) SLC2A4
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:7185054-7191367
CONAN: Copy Number AnalysisSLC2A4 
Mutations and Diseases : HGMDSLC2A4
OMIM138190   
MedgenSLC2A4
NextProtP14672 [Medical]
GENETestsSLC2A4
Disease Genetic AssociationSLC2A4
Huge Navigator SLC2A4 [HugePedia]  SLC2A4 [HugeCancerGEM]
snp3D : Map Gene to Disease6517
DGIdb (Drug Gene Interaction db)SLC2A4
BioCentury BCIQSLC2A4
General knowledge
Homologs : HomoloGeneSLC2A4
Homology/Alignments : Family Browser (UCSC)SLC2A4
Phylogenetic Trees/Animal Genes : TreeFamSLC2A4
Chemical/Protein Interactions : CTD6517
Chemical/Pharm GKB GenePA35879
Clinical trialSLC2A4
Cancer Resource (Charite)ENSG00000181856
Other databases
Probes
Litterature
PubMed153 Pubmed reference(s) in Entrez
CoreMineSLC2A4
GoPubMedSLC2A4
iHOPSLC2A4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Sep 5 12:10:53 CEST 2015

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