Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SLC2A4 (solute carrier family 2 (facilitated glucose transporter), member 4)

Identity

Other namesGLUT4
HGNC (Hugo) SLC2A4
LocusID (NCBI) 6517
Location 17p13.1
Location_base_pair Starts at 7185054 and ends at 7191367 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SLC2A4   11009
Cards
Entrez_Gene (NCBI)SLC2A4  6517  solute carrier family 2 (facilitated glucose transporter), member 4
GeneCards (Weizmann)SLC2A4
Ensembl (Hinxton)ENSG00000181856 [Gene_View]  chr17:7185054-7191367 [Contig_View]  SLC2A4 [Vega]
ICGC DataPortalENSG00000181856
cBioPortalSLC2A4
AceView (NCBI)SLC2A4
Genatlas (Paris)SLC2A4
WikiGenes6517
SOURCE (Princeton)NM_001042
Genomic and cartography
GoldenPath (UCSC)SLC2A4  -  17p13.1   chr17:7185054-7191367 +  17p13.1   [Description]    (hg19-Feb_2009)
EnsemblSLC2A4 - 17p13.1 [CytoView]
Mapping of homologs : NCBISLC2A4 [Mapview]
OMIM125853   138190   
Gene and transcription
Genbank (Entrez)AK300899 AK313372 AL521328 BC034387 BC069615
RefSeq transcript (Entrez)NM_001042
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_012127 NT_010718 NW_001838403 NW_004929405
Consensus coding sequences : CCDS (NCBI)SLC2A4
Cluster EST : UnigeneHs.380691 [ NCBI ]
CGAP (NCI)Hs.380691
Alternative Splicing : Fast-db (Paris)GSHG0012185
Alternative Splicing GalleryENSG00000181856
Gene ExpressionSLC2A4 [ NCBI-GEO ]     SLC2A4 [ SEEK ]   SLC2A4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14672 (Uniprot)
NextProtP14672  [Medical]
With graphics : InterProP14672
Splice isoforms : SwissVarP14672 (Swissvar)
Domaine pattern : Prosite (Expaxy)MFS (PS50850)    SUGAR_TRANSPORT_1 (PS00216)    SUGAR_TRANSPORT_2 (PS00217)   
Domains : Interpro (EBI)Glc_transpt_4 [organisation]   MFS_dom [organisation]   MFS_dom_general_subst_transpt [organisation]   Sub_transporter [organisation]   Sugar/inositol_transpt [organisation]   Sugar_transporter_CS [organisation]  
Related proteins : CluSTrP14672
Domain families : Pfam (Sanger)Sugar_tr (PF00083)   
Domain families : Pfam (NCBI)pfam00083   
DMDM Disease mutations6517
Blocks (Seattle)P14672
Human Protein AtlasENSG00000181856 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP14672
HPRD00688
IPIIPI00027281   IPI01013958   IPI00795418   
Protein Interaction databases
DIP (DOE-UCLA)P14672
IntAct (EBI)P14672
FunCoupENSG00000181856
BioGRIDSLC2A4
InParanoidP14672
Interologous Interaction database P14672
IntegromeDBSLC2A4
STRING (EMBL)SLC2A4
Ontologies - Pathways
Ontology : AmiGOglucose transmembrane transporter activity  protein binding  multivesicular body  plasma membrane  plasma membrane  integral component of plasma membrane  coated pit  carbohydrate metabolic process  hexose transport  external side of plasma membrane  amylopectin biosynthetic process  endomembrane system  vesicle membrane  glucose transport  membrane  clathrin-coated vesicle  trans-Golgi network transport vesicle  insulin-responsive compartment  insulin-responsive compartment  cellular response to insulin stimulus  sarcolemma  glucose homeostasis  small molecule metabolic process  response to ethanol  glucose import  perinuclear region of cytoplasm  brown fat cell differentiation  D-glucose transmembrane transporter activity  transmembrane transport  membrane organization  extracellular vesicular exosome  cellular response to osmotic stress  
Ontology : EGO-EBIglucose transmembrane transporter activity  protein binding  multivesicular body  plasma membrane  plasma membrane  integral component of plasma membrane  coated pit  carbohydrate metabolic process  hexose transport  external side of plasma membrane  amylopectin biosynthetic process  endomembrane system  vesicle membrane  glucose transport  membrane  clathrin-coated vesicle  trans-Golgi network transport vesicle  insulin-responsive compartment  insulin-responsive compartment  cellular response to insulin stimulus  sarcolemma  glucose homeostasis  small molecule metabolic process  response to ethanol  glucose import  perinuclear region of cytoplasm  brown fat cell differentiation  D-glucose transmembrane transporter activity  transmembrane transport  membrane organization  extracellular vesicular exosome  cellular response to osmotic stress  
Pathways : BIOCARTAGrowth Hormone Signaling Pathway [Genes]    Insulin Signaling Pathway [Genes]    Regulation of PGC-1a [Genes]   
Pathways : KEGGFoxO signaling pathway    Insulin signaling pathway    Adipocytokine signaling pathway    Type II diabetes mellitus   
Protein Interaction DatabaseSLC2A4
Wikipedia pathwaysSLC2A4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SLC2A4
snp3D : Map Gene to Disease6517
SNP (GeneSNP Utah)SLC2A4
SNP : HGBaseSLC2A4
Genetic variants : HAPMAPSLC2A4
Exome VariantSLC2A4
1000_GenomesSLC2A4 
ICGC programENSG00000181856 
Somatic Mutations in Cancer : COSMICSLC2A4 
CONAN: Copy Number AnalysisSLC2A4 
Mutations and Diseases : HGMDSLC2A4
Mutations and Diseases : intOGenSLC2A4
Genomic VariantsSLC2A4  SLC2A4 [DGVbeta]
dbVarSLC2A4
ClinVarSLC2A4
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM125853    138190   
MedgenSLC2A4
GENETestsSLC2A4
Disease Genetic AssociationSLC2A4
Huge Navigator SLC2A4 [HugePedia]  SLC2A4 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneSLC2A4
Homology/Alignments : Family Browser (UCSC)SLC2A4
Phylogenetic Trees/Animal Genes : TreeFamSLC2A4
Chemical/Protein Interactions : CTD6517
Chemical/Pharm GKB GenePA35879
Clinical trialSLC2A4
Cancer Resource (Charite)ENSG00000181856
Other databases
Probes
Litterature
PubMed146 Pubmed reference(s) in Entrez
CoreMineSLC2A4
iHOPSLC2A4
OncoSearchSLC2A4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:05:07 CEST 2014

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