Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SLC2A4 (solute carrier family 2 member 4)

Identity

Alias_namesGLUT4
solute carrier family 2 (facilitated glucose transporter)
HGNC (Hugo) SLC2A4
LocusID (NCBI) 6517
Atlas_Id 46491
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 7185054 and ends at 7191367 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SLC2A4 (17p13.1) / ERMAP (1p34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC2A4   11009
Cards
Entrez_Gene (NCBI)SLC2A4  6517  solute carrier family 2 member 4
AliasesGLUT4
GeneCards (Weizmann)SLC2A4
Ensembl hg19 (Hinxton)ENSG00000181856 [Gene_View]  chr17:7185054-7191367 [Contig_View]  SLC2A4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000181856 [Gene_View]  chr17:7185054-7191367 [Contig_View]  SLC2A4 [Vega]
ICGC DataPortalENSG00000181856
TCGA cBioPortalSLC2A4
AceView (NCBI)SLC2A4
Genatlas (Paris)SLC2A4
WikiGenes6517
SOURCE (Princeton)SLC2A4
Genetics Home Reference (NIH)SLC2A4
Genomic and cartography
GoldenPath hg19 (UCSC)SLC2A4  -     chr17:7185054-7191367 +  17p13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SLC2A4  -     17p13.1   [Description]    (hg38-Dec_2013)
EnsemblSLC2A4 - 17p13.1 [CytoView hg19]  SLC2A4 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBISLC2A4 [Mapview hg19]  SLC2A4 [Mapview hg38]
OMIM138190   
Gene and transcription
Genbank (Entrez)AK300899 AK313372 AL521328 BC034387 BC069615
RefSeq transcript (Entrez)NM_001042
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_012127 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)SLC2A4
Cluster EST : UnigeneHs.380691 [ NCBI ]
CGAP (NCI)Hs.380691
Alternative Splicing GalleryENSG00000181856
Gene ExpressionSLC2A4 [ NCBI-GEO ]   SLC2A4 [ EBI - ARRAY_EXPRESS ]   SLC2A4 [ SEEK ]   SLC2A4 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC2A4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6517
GTEX Portal (Tissue expression)SLC2A4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14672   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14672  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14672
Splice isoforms : SwissVarP14672
PhosPhoSitePlusP14672
Domaine pattern : Prosite (Expaxy)MFS (PS50850)    SUGAR_TRANSPORT_1 (PS00216)    SUGAR_TRANSPORT_2 (PS00217)   
Domains : Interpro (EBI)Glc_transpt_4    MFS_dom    MFS_sugar_transport_like    Sugar/inositol_transpt    Sugar_transporter_CS   
Domain families : Pfam (Sanger)Sugar_tr (PF00083)   
Domain families : Pfam (NCBI)pfam00083   
Conserved Domain (NCBI)SLC2A4
DMDM Disease mutations6517
Blocks (Seattle)SLC2A4
SuperfamilyP14672
Human Protein AtlasENSG00000181856
Peptide AtlasP14672
HPRD00688
IPIIPI00027281   IPI01013958   IPI00795418   
Protein Interaction databases
DIP (DOE-UCLA)P14672
IntAct (EBI)P14672
FunCoupENSG00000181856
BioGRIDSLC2A4
STRING (EMBL)SLC2A4
ZODIACSLC2A4
Ontologies - Pathways
QuickGOP14672
Ontology : AmiGOglucose transmembrane transporter activity  protein binding  multivesicular body  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  coated pit  carbohydrate metabolic process  external side of plasma membrane  amylopectin biosynthetic process  endomembrane system  vesicle membrane  glucose transport  membrane  clathrin-coated vesicle  trans-Golgi network transport vesicle  T-tubule  cytoplasmic vesicle membrane  insulin-responsive compartment  insulin-responsive compartment  cellular response to insulin stimulus  glucose homeostasis  membrane raft  response to ethanol  glucose import  perinuclear region of cytoplasm  brown fat cell differentiation  D-glucose transmembrane transporter activity  extracellular exosome  cellular response to hypoxia  cellular response to osmotic stress  glucose transmembrane transport  
Ontology : EGO-EBIglucose transmembrane transporter activity  protein binding  multivesicular body  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  coated pit  carbohydrate metabolic process  external side of plasma membrane  amylopectin biosynthetic process  endomembrane system  vesicle membrane  glucose transport  membrane  clathrin-coated vesicle  trans-Golgi network transport vesicle  T-tubule  cytoplasmic vesicle membrane  insulin-responsive compartment  insulin-responsive compartment  cellular response to insulin stimulus  glucose homeostasis  membrane raft  response to ethanol  glucose import  perinuclear region of cytoplasm  brown fat cell differentiation  D-glucose transmembrane transporter activity  extracellular exosome  cellular response to hypoxia  cellular response to osmotic stress  glucose transmembrane transport  
Pathways : BIOCARTAGrowth Hormone Signaling Pathway [Genes]    Insulin Signaling Pathway [Genes]    Regulation of PGC-1a [Genes]   
Pathways : KEGGFoxO signaling pathway    Insulin signaling pathway    Adipocytokine signaling pathway    Type II diabetes mellitus   
NDEx NetworkSLC2A4
Atlas of Cancer Signalling NetworkSLC2A4
Wikipedia pathwaysSLC2A4
Orthology - Evolution
OrthoDB6517
GeneTree (enSembl)ENSG00000181856
Phylogenetic Trees/Animal Genes : TreeFamSLC2A4
HOVERGENP14672
HOGENOMP14672
Homologs : HomoloGeneSLC2A4
Homology/Alignments : Family Browser (UCSC)SLC2A4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC2A4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC2A4
dbVarSLC2A4
ClinVarSLC2A4
1000_GenomesSLC2A4 
Exome Variant ServerSLC2A4
ExAC (Exome Aggregation Consortium)SLC2A4 (select the gene name)
Genetic variants : HAPMAP6517
Genomic Variants (DGV)SLC2A4 [DGVbeta]
DECIPHER (Syndromes)17:7185054-7191367  ENSG00000181856
CONAN: Copy Number AnalysisSLC2A4 
Mutations
ICGC Data PortalSLC2A4 
TCGA Data PortalSLC2A4 
Broad Tumor PortalSLC2A4
OASIS PortalSLC2A4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC2A4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC2A4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch SLC2A4
DgiDB (Drug Gene Interaction Database)SLC2A4
DoCM (Curated mutations)SLC2A4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC2A4 (select a term)
intoGenSLC2A4
Cancer3DSLC2A4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138190   
Orphanet
MedgenSLC2A4
Genetic Testing Registry SLC2A4
NextProtP14672 [Medical]
TSGene6517
GENETestsSLC2A4
Huge Navigator SLC2A4 [HugePedia]
snp3D : Map Gene to Disease6517
BioCentury BCIQSLC2A4
ClinGenSLC2A4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6517
Chemical/Pharm GKB GenePA35879
Clinical trialSLC2A4
Miscellaneous
canSAR (ICR)SLC2A4 (select the gene name)
Probes
Litterature
PubMed161 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC2A4
EVEXSLC2A4
GoPubMedSLC2A4
iHOPSLC2A4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:51:39 CET 2016

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