SLC2A5 (solute carrier family 2 member 5)

2003-05-01  

Identity

HGNC
LOCATION
1p36.23
LOCUSID
ALIAS
GLUT-5,GLUT5
FUSION GENES

Other Information

Locus ID:

NCBI: 6518
MIM: 138230
HGNC: 11010
Ensembl: ENSG00000142583

Variants:

dbSNP: 6518
ClinVar: 6518
TCGA: ENSG00000142583
COSMIC: SLC2A5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142583ENST00000377414P22732
ENSG00000142583ENST00000377414A0A140VJK5
ENSG00000142583ENST00000377424P22732
ENSG00000142583ENST00000464985K7EQI3
ENSG00000142583ENST00000473209K7EJR1
ENSG00000142583ENST00000474145K7EIT1
ENSG00000142583ENST00000479813K7EIT1
ENSG00000142583ENST00000484798K7EIT1
ENSG00000142583ENST00000486632K7EIT1
ENSG00000142583ENST00000487835K7EJZ0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Carbohydrate digestion and absorptionKEGGko04973
Carbohydrate digestion and absorptionKEGGhsa04973
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Hexose transportREACTOMER-HSA-189200
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Facilitative Na+-independent glucose transportersREACTOMER-HSA-428790
Class II GLUTsREACTOMER-HSA-428776
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
190917482009Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension.55
147574342004Facilitative glucose transporter gene expression in human lymphocytes, monocytes, and macrophages: a role for GLUT isoforms 1, 3, and 5 in the immune response and foam cell formation.49
168038532006Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle.30
128208982003Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2.15
172512782007Overexpression of GLUT5 in diabetic muscle is reversed by pioglitazone.15
219387422012Cellular distribution of Glut-1 and Glut-5 in benign and malignant human prostate tissue.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
184242532008De-phosphorylation of GR at Ser203 in nuclei associates with GR nuclear translocation and GLUT5 gene expression in Caco-2 cells.10

Citation

Dessen P

SLC2A5 (solute carrier family 2 member 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42320/slc2a5