SLC2A8 (solute carrier family 2 member 8)

2009-09-01  

Identity

HGNC
LOCATION
9q33.3
LOCUSID
ALIAS
GLUT8,GLUTX1
FUSION GENES

Other Information

Locus ID:

NCBI: 29988
MIM: 605245
HGNC: 13812
Ensembl: ENSG00000136856

Variants:

dbSNP: 29988
ClinVar: 29988
TCGA: ENSG00000136856
COSMIC: SLC2A8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136856ENST00000373352Q5VVW5
ENSG00000136856ENST00000373360Q5VVV9
ENSG00000136856ENST00000373371Q9NY64
ENSG00000136856ENST00000373371A0A024R871
ENSG00000136856ENST00000419132H0Y7M6
ENSG00000136856ENST00000419917Q5VVW0
ENSG00000136856ENST00000423934Q5VVV5
ENSG00000136856ENST00000430147Q5VVV4
ENSG00000136856ENST00000439597Q5VVV6
ENSG00000136856ENST00000451404Q5VVV3
ENSG00000136856ENST00000610552A0A087WT42

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Facilitative Na+-independent glucose transportersREACTOMER-HSA-428790
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
224529792012Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy.51
279221022016SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.28
245199322014Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis.26
167237382006Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex.17
232348772013Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease.12
118453302002The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa.11
195545042009Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma.4
209657182011Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).4
295901292018Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction.4
278183552017Glucose transporter 8 immunoreactivity in astrocytic and microglial cells in subependymal areas of human brains.2

Citation

Dessen P

SLC2A8 (solute carrier family 2 member 8)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51120/slc2a8