SLC30A1 (solute carrier family 30 member 1)

2009-03-01  

Identity

HGNC
LOCATION
1q32.3
LOCUSID
ALIAS
ZNT1,ZRC1

Other Information

Locus ID:

NCBI: 7779
MIM: 609521
HGNC: 11012
Ensembl: ENSG00000170385

Variants:

dbSNP: 7779
ClinVar: 7779
TCGA: ENSG00000170385
COSMIC: SLC30A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170385ENST00000367001Q9Y6M5

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Zinc transportersREACTOMER-HSA-435354
Zinc efflux and compartmentalization by the SLC30 familyREACTOMER-HSA-435368

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
181583192008Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses.58
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
193713532010Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain.24
214621062010Gastrointestinal factors influencing zinc absorption and homeostasis.24
179715002008Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9.22
186397462008Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain.22
161792632005Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease.21
268242222016Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc.18
249510512014ZnT-1 extrudes zinc from mammalian cells functioning as a Zn(2+)/H(+) exchanger.16

Citation

Dessen P

SLC30A1 (solute carrier family 30 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50685/slc30a1