SLC30A3 (solute carrier family 30 member 3)

2014-11-01  

Identity

HGNC
LOCATION
2p23.3
LOCUSID
ALIAS
ZNT3

Other Information

Locus ID:

NCBI: 7781
MIM: 602878
HGNC: 11014
Ensembl: ENSG00000115194

Variants:

dbSNP: 7781
ClinVar: 7781
TCGA: ENSG00000115194
COSMIC: SLC30A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115194ENST00000233535Q99726
ENSG00000115194ENST00000424577C9JHX4
ENSG00000115194ENST00000426569C9J1K4
ENSG00000115194ENST00000426924C9JV68
ENSG00000115194ENST00000432351C9JM13
ENSG00000115194ENST00000445870H7BZ83
ENSG00000115194ENST00000450118C9JHZ9

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Zinc transportersREACTOMER-HSA-435354
Zinc efflux and compartmentalization by the SLC30 familyREACTOMER-HSA-435368

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
251045582014Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment.27
179715002008Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9.22
186397462008Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain.22
195215262009SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity.18
249538732015Depression and synaptic zinc regulation in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia.11
252842862015Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis.11
146627992004Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells.10
268679002016The zinc transporter ZNT3 co-localizes with insulin in INS-1E pancreatic beta cells and influences cell survival, insulin secretion capacity, and ZNT8 expression.5
238493952014Allelic variants in the zinc transporter-3 gene, SLC30A3, a candidate gene identified from gene expression studies, show gender-specific association with schizophrenia.4
277501162016Common variants in the chromosome 2p23 region containing the SLC30A3 (ZnT3) gene are associated with schizophrenia in female but not male individuals in a large collection of European samples.4

Citation

Dessen P

SLC30A3 (solute carrier family 30 member 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73389/slc30a3