SLC30A5 (solute carrier family 30 member 5)

2014-11-01 Affiliation

Identity

HGNC

SLC30A5

LOCATION

5q13.1

LOCUSID

64924

ALIAS

ZNT5,ZNTL1,ZTL1,ZnT-5

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 64924
MIM: 607819
HGNC: 19089
Ensembl: ENSG00000145740

Variants:

dbSNP: 64924
ClinVar: 64924
TCGA: ENSG00000145740
COSMIC: SLC30A5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000145740	ENST00000380860	Q8TAD4
ENSG00000145740	ENST00000396591	Q8TAD4
ENSG00000145740	ENST00000502979	Q8TAD4
ENSG00000145740	ENST00000504103	D6REM2
ENSG00000145740	ENST00000511158	H0Y957
ENSG00000145740	ENST00000513937	H0YAH4
ENSG00000145740	ENST00000621204	Q9BY48

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Insulin processing	REACTOME	R-HSA-264876
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366
Metal ion SLC transporters	REACTOME	R-HSA-425410
Zinc transporters	REACTOME	R-HSA-435354
Zinc efflux and compartmentalization by the SLC30 family	REACTOME	R-HSA-435368

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
11904301	2002	Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells.	63
19759014	2009	Demonstration and characterization of the heterodimerization of ZnT5 and ZnT6 in the early secretory pathway.	39
22529353	2012	Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity.	39
11937503	2002	A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane.	30
20689807	2010	Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.	23
17971500	2008	Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9.	22
18639746	2008	Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain.	22
19064571	2008	Polymorphisms in mitochondrial genes and prostate cancer risk.	20
21887337	2011	Differential subcellular localization of the splice variants of the zinc transporter ZnT5 is dictated by the different C-terminal regions.	7
23275032	2013	Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis.	6

Citation

Dessen P

SLC30A5 (solute carrier family 30 member 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73390/slc30a5