SLC30A6 (solute carrier family 30 member 6)

2014-11-01 Affiliation

Identity

HGNC

SLC30A6

LOCATION

2p22.3

LOCUSID

55676

ALIAS

MST103,MSTP103,ZNT6

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 55676
MIM: 611148
HGNC: 19305
Ensembl: ENSG00000152683

Variants:

dbSNP: 55676
ClinVar: 55676
TCGA: ENSG00000152683
COSMIC: SLC30A6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000152683	ENST00000282587	Q6NXT4
ENSG00000152683	ENST00000357055	Q6NXT4
ENSG00000152683	ENST00000379343	Q6NXT4
ENSG00000152683	ENST00000406369	B5MCR8
ENSG00000152683	ENST00000435660	Q6NXT4
ENSG00000152683	ENST00000440718	C9JZR9
ENSG00000152683	ENST00000449777	F8WEL5
ENSG00000152683	ENST00000454324	F8WCU3
ENSG00000152683	ENST00000457724	F8WD78

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Insulin processing	REACTOME	R-HSA-264876
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366
Metal ion SLC transporters	REACTOME	R-HSA-425410
Zinc transporters	REACTOME	R-HSA-435354
Zinc efflux and compartmentalization by the SLC30 family	REACTOME	R-HSA-435368

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19759014	2009	Demonstration and characterization of the heterodimerization of ZnT5 and ZnT6 in the early secretory pathway.	39
16580781	2006	Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain.	24
19371353	2010	Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain.	24
17971500	2008	Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9.	22
18639746	2008	Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain.	22
19064571	2008	Polymorphisms in mitochondrial genes and prostate cancer risk.	20
20877624	2010	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	17
22349685	2012	Zinc transporter mRNA levels in Alzheimer's disease postmortem brain.	12
25284286	2015	Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis.	11
27661418	2016	Zinc transporters protein level in postmortem brain of depressed subjects and suicide victims.	3

Citation

Dessen P

SLC30A6 (solute carrier family 30 member 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73391/slc30a6