SLC31A1 (solute carrier family 31 member 1)

2009-08-01 Affiliation

Identity

HGNC

SLC31A1

LOCATION

9q32

LOCUSID

1317

ALIAS

COPT1,CTR1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1317
MIM: 603085
HGNC: 11016
Ensembl: ENSG00000136868

Variants:

dbSNP: 1317
ClinVar: 1317
TCGA: ENSG00000136868
COSMIC: SLC31A1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000136868	ENST00000374212	O15431
ENSG00000136868	ENST00000374212	A0A024R824

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Mineral absorption	KEGG	ko04978
Mineral absorption	KEGG	hsa04978
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366
Metal ion SLC transporters	REACTOME	R-HSA-425410
Platinum drug resistance	KEGG	ko01524
Platinum drug resistance	KEGG	hsa01524

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164713176	Platinum compounds	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation	ambiguous	PD	19525887
PA166123026	progression-free survival	Disease	VariantAnnotation	not associated	PD
PA166123207	overall survival	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PD
PA443340	Anemia	Disease	ClinicalAnnotation	associated	PD
PA443622	Carcinoma, Non-Small-Cell Lung	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PD	22516052, 22725681
PA443937	Drug Toxicity	Disease	ClinicalAnnotation	associated	PD
PA444773	Leukopenia	Disease	ClinicalAnnotation	associated	PD
PA445048	Nausea	Disease	ClinicalAnnotation	associated	PD
PA445113	Neutropenia	Disease	ClinicalAnnotation	associated	PD
PA445846	Thrombocytopenia	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD
PA446051	Vomiting	Disease	ClinicalAnnotation	associated	PD
PA448803	carboplatin	Chemical	ClinicalAnnotation	associated	PD	22725681
PA449014	cisplatin	Chemical	ClinicalAnnotation	associated	PD	22516052, 22725681

References

Pubmed ID	Year	Title	Citations
11983704	2002	Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake.	104
19240214	2009	Three-dimensional structure of the human copper transporter hCTR1.	87
12177073	2002	Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system.	79
12501239	2003	Copper-stimulated endocytosis and degradation of the human copper transporter, hCtr1.	76
19144690	2009	The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity.	75
16501047	2006	Projection structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture.	57
14976198	2004	Identification of methionine-rich clusters that regulate copper-stimulated endocytosis of the human Ctr1 copper transporter.	49
12023893	2002	Biochemical characterization and subcellular localization of human copper transporter 1 (hCTR1).	43
20699218	2010	Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability.	41
27270317	2016	NEAT1 upregulates EGCG-induced CTR1 to enhance cisplatin sensitivity in lung cancer cells.	41

Citation

Dessen P

SLC31A1 (solute carrier family 31 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/50996/slc31a1