SLC31A2 (solute carrier family 31 member 2)

2009-11-01  

Identity

HGNC
LOCATION
9q32
LOCUSID
ALIAS
COPT2,CTR2,hCTR2

Other Information

Locus ID:

NCBI: 1318
MIM: 603088
HGNC: 11017
Ensembl: ENSG00000136867

Variants:

dbSNP: 1318
ClinVar: 1318
TCGA: ENSG00000136867
COSMIC: SLC31A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136867ENST00000259392O15432
ENSG00000136867ENST00000259392Q53X94
ENSG00000136867ENST00000374220F2Z3D2

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176170602007Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake.56
195091352009Copper transporter 2 regulates the cellular accumulation and cytotoxicity of Cisplatin and Carboplatin.50
179446012008Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells.38
245222732014Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin.20
247037122015The role of Ctr1 and Ctr2 in mammalian copper homeostasis and platinum-based chemotherapy.13
287371292017Association between polymorphisms in CTR1, CTR2, ATP7A, and ATP7B and platinum resistance in epithelial ovarian cancer.9
285070972017Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.7
262053682015The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2).4
264115502016Decreased expression of CTR2 predicts poor prognosis of patients with clear cell renal cell carcinoma.2
235647802013Association of copper transporter expression with platinum resistance in epithelial ovarian cancer.0

Citation

Dessen P

SLC31A2 (solute carrier family 31 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51206/slc31a2