SLC34A2 (solute carrier family 34 member 2)

2010-12-01  

Identity

HGNC
LOCATION
4p15.2
LOCUSID
ALIAS
NAPI-3B,NAPI-IIb,NPTIIb,PULAM
FUSION GENES

Other Information

Locus ID:

NCBI: 10568
MIM: 604217
HGNC: 11020
Ensembl: ENSG00000157765

Variants:

dbSNP: 10568
ClinVar: 10568
TCGA: ENSG00000157765
COSMIC: SLC34A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157765ENST00000382051O95436
ENSG00000157765ENST00000503434O95436
ENSG00000157765ENST00000504570O95436
ENSG00000157765ENST00000507530D6RBC0
ENSG00000157765ENST00000513204D6RA94
ENSG00000157765ENST00000645788O95436

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
Metabolism of proteinsREACTOMER-HSA-392499
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Sodium-coupled phosphate cotransportersREACTOMER-HSA-427652
Type II Na+/Pi cotransportersREACTOMER-HSA-427589
Surfactant metabolismREACTOMER-HSA-5683826

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
169608012006Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis.63
170957432007Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis.34
281149372017Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway.32
196178342009Pulmonary alveolar microlithiasis: review and management.31
269109122016MicroRNA-410 acts as oncogene in NSCLC through downregulating SLC34A2 via activating Wnt/β-catenin pathway.20
204570632010Human eye colour and HERC2, OCA2 and MATP.14
265464322016Enhanced SLC34A2 in breast cancer stem cell-like cells induces chemotherapeutic resistance to doxorubicin via SLC34A2-Bmi1-ABCC5 signaling.11
231645462013SLC34A2 Gene mutation of pulmonary alveolar microlithiasis: report of four cases and review of literatures.10
261565862015The effects and mechanisms of SLC34A2 in tumorigenesis and progression of human non-small cell lung cancer.9
200460002010A frame-shift mutation in the SLC34A2 gene in three patients with pulmonary alveolar microlithiasis in an inbred family.7

Citation

Dessen P

SLC34A2 (solute carrier family 34 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-12-01

Online version: http://atlasgeneticsoncology.org/gene/51842/slc34a2