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SLC34A2 (solute carrier family 34 member 2)

Identity

Alias_namessolute carrier family 34 (sodium phosphate), member 2
solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
Alias_symbol (synonym)NAPI-3B
Other aliasNAPI-IIb
NPTIIb
HGNC (Hugo) SLC34A2
LocusID (NCBI) 10568
Atlas_Id 51842
Location 4p15.2  [Link to chromosome band 4p15]
Location_base_pair Starts at 25657435 and ends at 25680368 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CDHR1 (10q23.1) / SLC34A2 (4p15.2)ROS1 (6q22.1) / SLC34A2 (4p15.2)SLC34A2 (4p15.2) / ACTB (7p22.1)
SLC34A2 (4p15.2) / ADGRV1 (5q14.3)SLC34A2 (4p15.2) / CLDN7 (17p13.1)SLC34A2 (4p15.2) / EEA1 (12q22)
SLC34A2 (4p15.2) / ROS1 (6q22.1)SLC34A2 (4p15.2) / SLC34A2 (4p15.2)SLC34A2 (4p15.2) / ZBTB43 (9q33.3)
SLC34A2 4p15.2 / ROS1 6q22.1SLC34A2 4p15.2 / CLDN7 17p13.1SLC34A2 4p15.2 / EEA1 12q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Adenocarcinoma
Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)SLC34A2   11020
Cards
Entrez_Gene (NCBI)SLC34A2  10568  solute carrier family 34 member 2
AliasesNAPI-3B; NAPI-IIb; NPTIIb
GeneCards (Weizmann)SLC34A2
Ensembl hg19 (Hinxton)ENSG00000157765 [Gene_View]  chr4:25657435-25680368 [Contig_View]  SLC34A2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000157765 [Gene_View]  chr4:25657435-25680368 [Contig_View]  SLC34A2 [Vega]
ICGC DataPortalENSG00000157765
TCGA cBioPortalSLC34A2
AceView (NCBI)SLC34A2
Genatlas (Paris)SLC34A2
WikiGenes10568
SOURCE (Princeton)SLC34A2
Genetics Home Reference (NIH)SLC34A2
Genomic and cartography
GoldenPath hg19 (UCSC)SLC34A2  -     chr4:25657435-25680368 +  4p15.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SLC34A2  -     4p15.2   [Description]    (hg38-Dec_2013)
EnsemblSLC34A2 - 4p15.2 [CytoView hg19]  SLC34A2 - 4p15.2 [CytoView hg38]
Mapping of homologs : NCBISLC34A2 [Mapview hg19]  SLC34A2 [Mapview hg38]
OMIM265100   604217   610441   
Gene and transcription
Genbank (Entrez)AF111856 AF146796 AK075015 AK075045 AK075046
RefSeq transcript (Entrez)NM_001177998 NM_001177999 NM_006424
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_021185 NT_006316 NW_004929315
Consensus coding sequences : CCDS (NCBI)SLC34A2
Cluster EST : UnigeneHs.479372 [ NCBI ]
CGAP (NCI)Hs.479372
Alternative Splicing GalleryENSG00000157765
Gene ExpressionSLC34A2 [ NCBI-GEO ]   SLC34A2 [ EBI - ARRAY_EXPRESS ]   SLC34A2 [ SEEK ]   SLC34A2 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC34A2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10568
GTEX Portal (Tissue expression)SLC34A2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95436   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95436  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95436
Splice isoforms : SwissVarO95436
PhosPhoSitePlusO95436
Domains : Interpro (EBI)Na/Pi_transpt    Na/Pi_transpt_2B   
Domain families : Pfam (Sanger)Na_Pi_cotrans (PF02690)   
Domain families : Pfam (NCBI)pfam02690   
Conserved Domain (NCBI)SLC34A2
DMDM Disease mutations10568
Blocks (Seattle)SLC34A2
SuperfamilyO95436
Human Protein AtlasENSG00000157765
Peptide AtlasO95436
HPRD07251
IPIIPI00007910   IPI00657725   IPI00964495   IPI00964227   
Protein Interaction databases
DIP (DOE-UCLA)O95436
IntAct (EBI)O95436
FunCoupENSG00000157765
BioGRIDSLC34A2
STRING (EMBL)SLC34A2
ZODIACSLC34A2
Ontologies - Pathways
QuickGOO95436
Ontology : AmiGOin utero embryonic development  inorganic phosphate transmembrane transporter activity  sodium:phosphate symporter activity  cytoplasm  plasma membrane  integral component of plasma membrane  brush border  phosphate ion transport  sodium-dependent phosphate transmembrane transporter activity  sodium-dependent phosphate transmembrane transporter activity  integral component of membrane  integral component of membrane  apical plasma membrane  cellular phosphate ion homeostasis  sodium ion binding  brush border membrane  vesicle  phosphate ion transmembrane transport  sodium ion transmembrane transport  phosphate ion binding  response to estrogen  cellular protein metabolic process  sodium-dependent phosphate transport  transmembrane transport  
Ontology : EGO-EBIin utero embryonic development  inorganic phosphate transmembrane transporter activity  sodium:phosphate symporter activity  cytoplasm  plasma membrane  integral component of plasma membrane  brush border  phosphate ion transport  sodium-dependent phosphate transmembrane transporter activity  sodium-dependent phosphate transmembrane transporter activity  integral component of membrane  integral component of membrane  apical plasma membrane  cellular phosphate ion homeostasis  sodium ion binding  brush border membrane  vesicle  phosphate ion transmembrane transport  sodium ion transmembrane transport  phosphate ion binding  response to estrogen  cellular protein metabolic process  sodium-dependent phosphate transport  transmembrane transport  
Pathways : KEGGMineral absorption   
NDEx NetworkSLC34A2
Atlas of Cancer Signalling NetworkSLC34A2
Wikipedia pathwaysSLC34A2
Orthology - Evolution
OrthoDB10568
GeneTree (enSembl)ENSG00000157765
Phylogenetic Trees/Animal Genes : TreeFamSLC34A2
HOVERGENO95436
HOGENOMO95436
Homologs : HomoloGeneSLC34A2
Homology/Alignments : Family Browser (UCSC)SLC34A2
Gene fusions - Rearrangements
Fusion : MitelmanSLC34A2/ACTB [4p15.2/7p22.1]  
Fusion : MitelmanSLC34A2/CLDN7 [4p15.2/17p13.1]  [t(4;17)(p15;p13)]  
Fusion : MitelmanSLC34A2/EEA1 [4p15.2/12q22]  [t(4;12)(p15;q22)]  
Fusion : MitelmanSLC34A2/ROS1 [4p15.2/6q22.1]  [t(4;6)(p15;q22)]  
Fusion: TCGASLC34A2 4p15.2 CLDN7 17p13.1 THCA
Fusion: TCGASLC34A2 4p15.2 EEA1 12q22 LUAD
Fusion Cancer (Beijing)CDHR1 [10q23.1]  -  SLC34A2 [4p15.2]  [FUSC002564]
Fusion Cancer (Beijing)SLC34A2 [4p15.2]  -  GPR98 [FUSC002594]  [FUSC002594]  [FUSC002594]
Fusion Cancer (Beijing)SLC34A2 [4p15.2]  -  ROS1 [6q22.1]  [FUSC003670]  [FUSC003670]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC34A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC34A2
dbVarSLC34A2
ClinVarSLC34A2
1000_GenomesSLC34A2 
Exome Variant ServerSLC34A2
ExAC (Exome Aggregation Consortium)SLC34A2 (select the gene name)
Genetic variants : HAPMAP10568
Genomic Variants (DGV)SLC34A2 [DGVbeta]
DECIPHER (Syndromes)4:25657435-25680368  ENSG00000157765
CONAN: Copy Number AnalysisSLC34A2 
Mutations
ICGC Data PortalSLC34A2 
TCGA Data PortalSLC34A2 
Broad Tumor PortalSLC34A2
OASIS PortalSLC34A2 [ Somatic mutations - Copy number]
Cancer Gene: CensusSLC34A2 
Somatic Mutations in Cancer : COSMICSLC34A2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC34A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC34A2
DgiDB (Drug Gene Interaction Database)SLC34A2
DoCM (Curated mutations)SLC34A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC34A2 (select a term)
intoGenSLC34A2
Cancer3DSLC34A2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM265100    604217    610441   
Orphanet10797   
MedgenSLC34A2
Genetic Testing Registry SLC34A2
NextProtO95436 [Medical]
TSGene10568
GENETestsSLC34A2
Huge Navigator SLC34A2 [HugePedia]
snp3D : Map Gene to Disease10568
BioCentury BCIQSLC34A2
ClinGenSLC34A2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10568
Chemical/Pharm GKB GenePA35888
Clinical trialSLC34A2
Miscellaneous
canSAR (ICR)SLC34A2 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC34A2
EVEXSLC34A2
GoPubMedSLC34A2
iHOPSLC34A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:19:44 CEST 2017

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