SLC39A14 (solute carrier family 39 member 14)

2011-04-01  

Identity

HGNC
LOCATION
8p21.3
LOCUSID
ALIAS
HCIN,HMNDYT2,LZT-Hs4,NET34,ZIP14,cig19
FUSION GENES

Other Information

Locus ID:

NCBI: 23516
MIM: 608736
HGNC: 20858
Ensembl: ENSG00000104635

Variants:

dbSNP: 23516
ClinVar: 23516
TCGA: ENSG00000104635
COSMIC: SLC39A14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104635ENST00000240095Q15043
ENSG00000104635ENST00000240095A0A0S2Z534
ENSG00000104635ENST00000289952Q15043
ENSG00000104635ENST00000359741Q15043
ENSG00000104635ENST00000381237Q15043
ENSG00000104635ENST00000517370E5RFT1
ENSG00000104635ENST00000517552E5RJG5
ENSG00000104635ENST00000519960E5RJ40
ENSG00000104635ENST00000520644E5RGA7
ENSG00000104635ENST00000520832E5RFF5
ENSG00000104635ENST00000522881E5RIP4
ENSG00000104635ENST00000524285E5RFZ8

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Zinc transportersREACTOMER-HSA-435354
Zinc influx into cells by the SLC39 gene familyREACTOMER-HSA-442380
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447278DepressionDiseaseClinicalAnnotationassociatedPD20970119
PA450657nortriptylineChemicalClinicalAnnotationassociatedPD20970119

References

Pubmed IDYearTitleCitations
158636132005Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response.160
206827812010ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin.62
156423542005Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14.58
223185082012Physiologic implications of metal-ion transport by ZIP14 and ZIP8.56
231102402012Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia).52
272311422016Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia.52
209380522011Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway.35
185247642008The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells.33
214621062010Gastrointestinal factors influencing zinc absorption and homeostasis.24
213737792012ZIP14 zinc transporter downregulation and zinc depletion in the development and progression of hepatocellular cancer.21

Citation

Dessen P

SLC39A14 (solute carrier family 39 member 14)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/43062/slc39a14