SLC39A3 (solute carrier family 39 member 3)

2012-02-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
ZIP-3,ZIP3
FUSION GENES

Other Information

Locus ID:

NCBI: 29985
MIM: 612168
HGNC: 17128
Ensembl: ENSG00000141873

Variants:

dbSNP: 29985
ClinVar: 29985
TCGA: ENSG00000141873
COSMIC: SLC39A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141873ENST00000269740Q9BRY0
ENSG00000141873ENST00000455372Q9BRY0
ENSG00000141873ENST00000545664F5H385
ENSG00000141873ENST00000589166K7ENJ1
ENSG00000141873ENST00000589363K7EJZ1

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Zinc transportersREACTOMER-HSA-435354
Zinc influx into cells by the SLC39 gene familyREACTOMER-HSA-442380

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
145259872003Structure, function, and regulation of a subfamily of mouse zinc transporter genes.48
175506122007hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands.40
193080212009Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.29
216138272011Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma.24
182790332008Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions.23
224271552012Evidence for changes in RREB-1, ZIP3, and Zinc in the early development of pancreatic adenocarcinoma.15
210530942011Expression of the zinc transporters genes and metallothionein in obese women.4

Citation

Dessen P

SLC39A3 (solute carrier family 39 member 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52588/slc39a3