SLC39A5 (solute carrier family 39 member 5)

2016-05-01  

Identity

HGNC
SLC39A5
LOCATION
12q13.3
LOCUSID
283375
ALIAS
LZT-Hs7,MYP24,ZIP5

Other Information

Locus ID:

NCBI: 283375
MIM: 608730
HGNC: 20502
Ensembl: ENSG00000139540

Variants:

dbSNP: 283375
ClinVar: 283375
TCGA: ENSG00000139540
COSMIC: SLC39A5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139540ENST00000266980Q6ZMH5
ENSG00000139540ENST00000266980A0A024RB24
ENSG00000139540ENST00000417965C9JPS6
ENSG00000139540ENST00000419753C9JPS5
ENSG00000139540ENST00000424625C9JIB2
ENSG00000139540ENST00000436633C9JB28
ENSG00000139540ENST00000437277C9JVC6
ENSG00000139540ENST00000454355Q6ZMH5
ENSG00000139540ENST00000454355A0A024RB24

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Zinc transportersREACTOMER-HSA-435354
Zinc influx into cells by the SLC39 gene familyREACTOMER-HSA-442380

References

Pubmed IDYearTitleCitations
255251682014Detection of mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 families with early-onset high myopia by exome sequencing.20
261339792015Knockdown of zinc transporter ZIP5 (SLC39A5) expression significantly inhibits human esophageal cancer progression.8
153221182004The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells.0
274581022016Knockdown of Zinc Transporter ZIP5 by RNA Interference Inhibits Esophageal Cancer Growth In Vivo.0

Citation

Dessen P

SLC39A5 (solute carrier family 39 member 5)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55757/slc39a5