Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SLC39A8 (solute carrier family 39 member 8)

Identity

Alias (NCBI)BIGM103
CDG2N
LZT-Hs6
PP3105
ZIP8
HGNC (Hugo) SLC39A8
HGNC Alias symbBIGM103
HGNC Previous namesolute carrier family 39 (metal ion transporter), member 8
 solute carrier family 39 (zinc transporter), member 8
LocusID (NCBI) 64116
Atlas_Id 57734
Location 4q24  [Link to chromosome band 4q24]
Location_base_pair Starts at 102261664 and ends at 102345191 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HAUS6 (9p22.1) / SLC39A8 (4q24)SLC39A8 (4q24) / GLS (2q32.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SLC39A8   20862
Cards
Entrez_Gene (NCBI)SLC39A8    solute carrier family 39 member 8
AliasesBIGM103; CDG2N; LZT-Hs6; PP3105; 
ZIP8
GeneCards (Weizmann)SLC39A8
Ensembl hg19 (Hinxton)ENSG00000138821 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138821 [Gene_View]  ENSG00000138821 [Sequence]  chr4:102261664-102345191 [Contig_View]  SLC39A8 [Vega]
ICGC DataPortalENSG00000138821
TCGA cBioPortalSLC39A8
AceView (NCBI)SLC39A8
Genatlas (Paris)SLC39A8
SOURCE (Princeton)SLC39A8
Genetics Home Reference (NIH)SLC39A8
Genomic and cartography
GoldenPath hg38 (UCSC)SLC39A8  -     chr4:102261664-102345191 -  4q24   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC39A8  -     4q24   [Description]    (hg19-Feb_2009)
GoldenPathSLC39A8 - 4q24 [CytoView hg19]  SLC39A8 - 4q24 [CytoView hg38]
ImmunoBaseENSG00000138821
Genome Data Viewer NCBISLC39A8 [Mapview hg19]  
OMIM608732   616721   
Gene and transcription
Genbank (Entrez)AB020969 AB020970 AB040120 AF193052 AK027652
RefSeq transcript (Entrez)NM_001135146 NM_001135147 NM_001135148 NM_022154
Consensus coding sequences : CCDS (NCBI)SLC39A8
Gene ExpressionSLC39A8 [ NCBI-GEO ]   SLC39A8 [ EBI - ARRAY_EXPRESS ]   SLC39A8 [ SEEK ]   SLC39A8 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC39A8 [ Firebrowse - Broad ]
GenevisibleExpression of SLC39A8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64116
GTEX Portal (Tissue expression)SLC39A8
Human Protein AtlasENSG00000138821-SLC39A8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C0K1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C0K1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C0K1
PhosPhoSitePlusQ9C0K1
Domains : Interpro (EBI)ZIP   
Domain families : Pfam (Sanger)Zip (PF02535)   
Domain families : Pfam (NCBI)pfam02535   
Conserved Domain (NCBI)SLC39A8
SuperfamilyQ9C0K1
AlphaFold pdb e-kbQ9C0K1   
Human Protein Atlas [tissue]ENSG00000138821-SLC39A8 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9C0K1
IntAct (EBI)Q9C0K1
BioGRIDSLC39A8
STRING (EMBL)SLC39A8
ZODIACSLC39A8
Ontologies - Pathways
QuickGOQ9C0K1
Ontology : AmiGOiron ion transmembrane transporter activity  manganese ion transmembrane transporter activity  zinc ion transmembrane transporter activity  zinc ion transmembrane transporter activity  zinc ion transmembrane transporter activity  lysosomal membrane  plasma membrane  plasma membrane  integral component of plasma membrane  transcription, DNA-templated  regulation of transcription, DNA-templated  protein N-linked glycosylation  arginine metabolic process  cobalt ion transport  zinc ion transport  cellular cadmium ion homeostasis  cellular zinc ion homeostasis  cellular zinc ion homeostasis  cadmium ion transmembrane transporter activity  cobalt ion transmembrane transporter activity  bicarbonate transmembrane transporter activity  anion:cation symporter activity  inorganic anion transport  bicarbonate transport  basolateral plasma membrane  apical plasma membrane  cellular manganese ion homeostasis  extracellular matrix organization  organelle membrane  regulation of membrane potential  leukocyte adhesion to arterial endothelial cell  cadmium ion transmembrane transport  manganese ion transmembrane transport  zinc ion transmembrane transport  zinc ion transmembrane transport  zinc ion transmembrane transport  zinc ion import across plasma membrane  zinc ion import across plasma membrane  selenite:proton symporter activity  plasma membrane selenite transport  iron ion import across plasma membrane  zinc:bicarbonate symporter activity  cartilage homeostasis  mitochondrial manganese ion transmembrane transport  
Ontology : EGO-EBIiron ion transmembrane transporter activity  manganese ion transmembrane transporter activity  zinc ion transmembrane transporter activity  zinc ion transmembrane transporter activity  zinc ion transmembrane transporter activity  lysosomal membrane  plasma membrane  plasma membrane  integral component of plasma membrane  transcription, DNA-templated  regulation of transcription, DNA-templated  protein N-linked glycosylation  arginine metabolic process  cobalt ion transport  zinc ion transport  cellular cadmium ion homeostasis  cellular zinc ion homeostasis  cellular zinc ion homeostasis  cadmium ion transmembrane transporter activity  cobalt ion transmembrane transporter activity  bicarbonate transmembrane transporter activity  anion:cation symporter activity  inorganic anion transport  bicarbonate transport  basolateral plasma membrane  apical plasma membrane  cellular manganese ion homeostasis  extracellular matrix organization  organelle membrane  regulation of membrane potential  leukocyte adhesion to arterial endothelial cell  cadmium ion transmembrane transport  manganese ion transmembrane transport  zinc ion transmembrane transport  zinc ion transmembrane transport  zinc ion transmembrane transport  zinc ion import across plasma membrane  zinc ion import across plasma membrane  selenite:proton symporter activity  plasma membrane selenite transport  iron ion import across plasma membrane  zinc:bicarbonate symporter activity  cartilage homeostasis  mitochondrial manganese ion transmembrane transport  
NDEx NetworkSLC39A8
Atlas of Cancer Signalling NetworkSLC39A8
Wikipedia pathwaysSLC39A8
Orthology - Evolution
OrthoDB64116
GeneTree (enSembl)ENSG00000138821
Phylogenetic Trees/Animal Genes : TreeFamSLC39A8
Homologs : HomoloGeneSLC39A8
Homology/Alignments : Family Browser (UCSC)SLC39A8
Gene fusions - Rearrangements
Fusion : QuiverSLC39A8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC39A8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC39A8
dbVarSLC39A8
ClinVarSLC39A8
MonarchSLC39A8
1000_GenomesSLC39A8 
Exome Variant ServerSLC39A8
GNOMAD BrowserENSG00000138821
Varsome BrowserSLC39A8
ACMGSLC39A8 variants
VarityQ9C0K1
Genomic Variants (DGV)SLC39A8 [DGVbeta]
DECIPHERSLC39A8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC39A8 
Mutations
ICGC Data PortalSLC39A8 
TCGA Data PortalSLC39A8 
Broad Tumor PortalSLC39A8
OASIS PortalSLC39A8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC39A8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSLC39A8
Mutations and Diseases : HGMDSLC39A8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSLC39A8
DgiDB (Drug Gene Interaction Database)SLC39A8
DoCM (Curated mutations)SLC39A8
CIViC (Clinical Interpretations of Variants in Cancer)SLC39A8
Cancer3DSLC39A8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608732    616721   
Orphanet
DisGeNETSLC39A8
MedgenSLC39A8
Genetic Testing Registry SLC39A8
NextProtQ9C0K1 [Medical]
GENETestsSLC39A8
Target ValidationSLC39A8
Huge Navigator SLC39A8 [HugePedia]
ClinGenSLC39A8
Clinical trials, drugs, therapy
MyCancerGenomeSLC39A8
Protein Interactions : CTDSLC39A8
Pharm GKB GenePA134931507
PharosQ9C0K1
Clinical trialSLC39A8
Miscellaneous
canSAR (ICR)SLC39A8
HarmonizomeSLC39A8
DataMed IndexSLC39A8
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSLC39A8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:31:49 CEST 2021

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