Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SLC45A3 (solute carrier family 45 member 3)

Identity

Alias_namesPCANAP6
PCANAP2
PCANAP8
prostate cancer associated protein 6
prostate cancer associated protein 2
prostate cancer associated protein 8
solute carrier family 45, member 3
Alias_symbol (synonym)IPCA-6
prostein
IPCA-2
IPCA-8
Other aliasIPCA6
PRST
HGNC (Hugo) SLC45A3
LocusID (NCBI) 85414
Atlas_Id 41657
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 205657853 and ends at 205680502 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		ELK4 (1q32.1) / SLC45A3 (1q32.1)ETV1 (7p21.2) / SLC45A3 (1q32.1)GRHL2 (8q22.3) / SLC45A3 (1q32.1)
PRKCA (17q24.2) / SLC45A3 (1q32.1)SLC45A3 (1q32.1) / BRAF (7q34)SLC45A3 (1q32.1) / ELK4 (1q32.1)
SLC45A3 (1q32.1) / ERG (21q22.2)SLC45A3 (1q32.1) / ETV1 (7p21.2)SLC45A3 (1q32.1) / ETV4 (17q21.31)
SLC45A3 (1q32.1) / ETV5 (3q27.2)SLC45A3 (1q32.1) / FGFR2 (10q26.13)SLC45A3 (1q32.1) / FLI1 (11q24.3)
SLC45A3 (1q32.1) / MLLT1 (19p13.3)SLC45A3 1q32.1 / BRAF 7q34SLC45A3 1q32.1 / ELK4 1q32.1
SLC45A3 1q32.1 / ERG 21q22.2SLC45A3 1q32.1 / ETV1 7p21.2SLC45A3 1q32.1 / ETV5 3q27.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Breakpoints

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Prostate tumors: an overview
Prostate: Carcinoma with t(8;21)(q24;q22) NDRG1/ERG

External links

Nomenclature
HGNC (Hugo)SLC45A3   8642
Cards
Entrez_Gene (NCBI)SLC45A3  85414  solute carrier family 45 member 3
AliasesIPCA-2; IPCA-6; IPCA-8; IPCA6; 
PCANAP2; PCANAP6; PCANAP8; PRST
GeneCards (Weizmann)SLC45A3
Ensembl hg19 (Hinxton)ENSG00000158715 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158715 [Gene_View]  chr1:205657853-205680502 [Contig_View]  SLC45A3 [Vega]
ICGC DataPortalENSG00000158715
TCGA cBioPortalSLC45A3
AceView (NCBI)SLC45A3
Genatlas (Paris)SLC45A3
WikiGenes85414
SOURCE (Princeton)SLC45A3
Genetics Home Reference (NIH)SLC45A3
Genomic and cartography
GoldenPath hg38 (UCSC)SLC45A3  -     chr1:205657853-205680502 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC45A3  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblSLC45A3 - 1q32.1 [CytoView hg19]  SLC45A3 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBISLC45A3 [Mapview hg19]  SLC45A3 [Mapview hg38]
OMIM605097   
Gene and transcription
Genbank (Entrez)AK290364 AK313479 AL832933 AY033593 BC050416
RefSeq transcript (Entrez)NM_033102
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLC45A3
Cluster EST : UnigeneHs.278695 [ NCBI ]
CGAP (NCI)Hs.278695
Alternative Splicing GalleryENSG00000158715
Gene ExpressionSLC45A3 [ NCBI-GEO ]   SLC45A3 [ EBI - ARRAY_EXPRESS ]   SLC45A3 [ SEEK ]   SLC45A3 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC45A3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85414
GTEX Portal (Tissue expression)SLC45A3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96JT2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96JT2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96JT2
Splice isoforms : SwissVarQ96JT2
PhosPhoSitePlusQ96JT2
Domains : Interpro (EBI)MFS    MFS_dom   
Domain families : Pfam (Sanger)MFS_1 (PF07690)   
Domain families : Pfam (NCBI)pfam07690   
Conserved Domain (NCBI)SLC45A3
DMDM Disease mutations85414
Blocks (Seattle)SLC45A3
SuperfamilyQ96JT2
Human Protein AtlasENSG00000158715
Peptide AtlasQ96JT2
HPRD16312
IPIIPI00064353   
Protein Interaction databases
DIP (DOE-UCLA)Q96JT2
IntAct (EBI)Q96JT2
FunCoupENSG00000158715
BioGRIDSLC45A3
STRING (EMBL)SLC45A3
ZODIACSLC45A3
Ontologies - Pathways
QuickGOQ96JT2
Ontology : AmiGOplasma membrane  sucrose:proton symporter activity  positive regulation of glucose metabolic process  glucose transport  sucrose transport  integral component of membrane  carbohydrate transmembrane transport  positive regulation of fatty acid biosynthetic process  regulation of oligodendrocyte differentiation  sugar transmembrane transporter activity  
Ontology : EGO-EBIplasma membrane  sucrose:proton symporter activity  positive regulation of glucose metabolic process  glucose transport  sucrose transport  integral component of membrane  carbohydrate transmembrane transport  positive regulation of fatty acid biosynthetic process  regulation of oligodendrocyte differentiation  sugar transmembrane transporter activity  
Pathways : KEGGTranscriptional misregulation in cancer    MicroRNAs in cancer   
NDEx NetworkSLC45A3
Atlas of Cancer Signalling NetworkSLC45A3
Wikipedia pathwaysSLC45A3
Orthology - Evolution
OrthoDB85414
GeneTree (enSembl)ENSG00000158715
Phylogenetic Trees/Animal Genes : TreeFamSLC45A3
HOVERGENQ96JT2
HOGENOMQ96JT2
Homologs : HomoloGeneSLC45A3
Homology/Alignments : Family Browser (UCSC)SLC45A3
Gene fusions - Rearrangements
Fusion : MitelmanSLC45A3/BRAF [1q32.1/7q34]  
Fusion : MitelmanSLC45A3/ELK4 [1q32.1/1q32.1]  [t(1;1)(q32;q32)]  
Fusion : MitelmanSLC45A3/ERG [1q32.1/21q22.2]  [del(21)(q22q22)]  [t(1;21)(q32;q22)]  
[t(21;21)(q22;q22)]  
Fusion : MitelmanSLC45A3/ETV1 [1q32.1/7p21.2]  [t(1;7)(q32;p21)]  
Fusion : MitelmanSLC45A3/ETV4 [1q32.1/17q21.31]  [t(1;17)(q32;q21)]  
Fusion : MitelmanSLC45A3/ETV5 [1q32.1/3q27.2]  [t(1;3)(q32;q27)]  
Fusion : MitelmanSLC45A3/FGFR2 [1q32.1/10q26.13]  [t(1;10)(q32;q26)]  
Fusion : MitelmanSLC45A3/FLI1 [1q32.1/11q24.3]  [t(1;11)(q32;q24)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC45A3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC45A3
dbVarSLC45A3
ClinVarSLC45A3
1000_GenomesSLC45A3 
Exome Variant ServerSLC45A3
ExAC (Exome Aggregation Consortium)SLC45A3 (select the gene name)
Genetic variants : HAPMAP85414
Genomic Variants (DGV)SLC45A3 [DGVbeta]
DECIPHERSLC45A3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC45A3 
Mutations
ICGC Data PortalSLC45A3 
TCGA Data PortalSLC45A3 
Broad Tumor PortalSLC45A3
OASIS PortalSLC45A3 [ Somatic mutations - Copy number]
Cancer Gene: CensusSLC45A3 
Somatic Mutations in Cancer : COSMICSLC45A3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC45A3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC45A3
DgiDB (Drug Gene Interaction Database)SLC45A3
DoCM (Curated mutations)SLC45A3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC45A3 (select a term)
intoGenSLC45A3
Cancer3DSLC45A3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605097   
Orphanet
MedgenSLC45A3
Genetic Testing Registry SLC45A3
NextProtQ96JT2 [Medical]
TSGene85414
GENETestsSLC45A3
Target ValidationSLC45A3
Huge Navigator SLC45A3 [HugePedia]
snp3D : Map Gene to Disease85414
BioCentury BCIQSLC45A3
ClinGenSLC45A3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD85414
Chemical/Pharm GKB GenePA32981
Clinical trialSLC45A3
Miscellaneous
canSAR (ICR)SLC45A3 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC45A3
EVEXSLC45A3
GoPubMedSLC45A3
iHOPSLC45A3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:31:45 CEST 2017
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.