SLC47A1 (solute carrier family 47 member 1)

2017-04-01  

Identity

HGNC
LOCATION
17p11.2
LOCUSID
ALIAS
MATE1
FUSION GENES

Other Information

Locus ID:

NCBI: 55244
MIM: 609832
HGNC: 25588
Ensembl: ENSG00000142494

Variants:

dbSNP: 55244
ClinVar: 55244
TCGA: ENSG00000142494
COSMIC: SLC47A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142494ENST00000270570Q96FL8
ENSG00000142494ENST00000395585Q96FL8
ENSG00000142494ENST00000436810E7EX57
ENSG00000142494ENST00000571335J3KSS8
ENSG00000142494ENST00000575023I3L345
ENSG00000142494ENST00000581558J3KRZ3

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166163418rucaparibChemicalLabelAnnotationassociated
PA443890Diabetes Mellitus, Type 2DiseaseClinicalAnnotationassociatedPKPD22882994, 23267855, 23873119, 26004431, 28834135
PA445376Polycystic Ovary SyndromeDiseaseClinicalAnnotationassociatedPKPD22882994, 23267855, 23873119, 26004431, 28834135
PA450395metforminChemicalClinicalAnnotation, Literature, MultilinkAnnotation, PathwayassociatedPKPD22722338, 22882994, 23267855, 23873119, 24624919, 26004431, 28834135

References

Pubmed IDYearTitleCitations
163307702005A human transporter protein that mediates the final excretion step for toxic organic cations.126
206826872010Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.88
175095342007Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.86
195360682009The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.68
192288092009Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study.67
192288092009Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study.67
232678552013The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin.42
198982632010Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response.38
198982632010Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response.38
174951252007Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family.32

Citation

Dessen P

SLC47A1 (solute carrier family 47 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56745/slc47a1