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SLC4A10 (solute carrier family 4 member 10)

Identity

Alias_namessolute carrier family 4, sodium bicarbonate transporter-like, member 10
solute carrier family 4, sodium bicarbonate transporter, member 10
Alias_symbol (synonym)NBCn2
NCBE
Other alias
HGNC (Hugo) SLC4A10
LocusID (NCBI) 57282
Atlas_Id 46744
Location 2q24.2  [Link to chromosome band 2q24]
Location_base_pair Starts at 161624335 and ends at 161985276 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANKRD26P1 (16q11.2) / SLC4A10 (2q24.2)LCP1 (13q14.13) / SLC4A10 (2q24.2)SLC4A10 (2q24.2) / ARL13B (3q11.1)
SLC4A10 (2q24.2) / SLC4A10 (2q24.2)TRIP12 (2q36.3) / SLC4A10 (2q24.2)TRIP12 2q36.3 / SLC4A10 2q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)SLC4A10   13811
Cards
Entrez_Gene (NCBI)SLC4A10  57282  solute carrier family 4 member 10
AliasesNBCn2; NCBE
GeneCards (Weizmann)SLC4A10
Ensembl hg19 (Hinxton)ENSG00000144290 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144290 [Gene_View]  chr2:161624335-161985276 [Contig_View]  SLC4A10 [Vega]
ICGC DataPortalENSG00000144290
TCGA cBioPortalSLC4A10
AceView (NCBI)SLC4A10
Genatlas (Paris)SLC4A10
WikiGenes57282
SOURCE (Princeton)SLC4A10
Genetics Home Reference (NIH)SLC4A10
Genomic and cartography
GoldenPath hg38 (UCSC)SLC4A10  -     chr2:161624335-161985276 +  2q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC4A10  -     2q24.2   [Description]    (hg19-Feb_2009)
EnsemblSLC4A10 - 2q24.2 [CytoView hg19]  SLC4A10 - 2q24.2 [CytoView hg38]
Mapping of homologs : NCBISLC4A10 [Mapview hg19]  SLC4A10 [Mapview hg38]
OMIM605556   
Gene and transcription
Genbank (Entrez)AB040457 AK293793 AK294767 AK308529 AK309839
RefSeq transcript (Entrez)NM_001178015 NM_001178016 NM_022058
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLC4A10
Cluster EST : UnigeneHs.333958 [ NCBI ]
CGAP (NCI)Hs.333958
Alternative Splicing GalleryENSG00000144290
Gene ExpressionSLC4A10 [ NCBI-GEO ]   SLC4A10 [ EBI - ARRAY_EXPRESS ]   SLC4A10 [ SEEK ]   SLC4A10 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC4A10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57282
GTEX Portal (Tissue expression)SLC4A10
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6U841   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6U841  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6U841
Splice isoforms : SwissVarQ6U841
PhosPhoSitePlusQ6U841
Domains : Interpro (EBI)Band3_cytoplasmic_dom    HCO3_transpt_C    HCO3_transpt_euk    Na/HCO3_transpt    PTrfase/Anion_transptr   
Domain families : Pfam (Sanger)Band_3_cyto (PF07565)    HCO3_cotransp (PF00955)   
Domain families : Pfam (NCBI)pfam07565    pfam00955   
Conserved Domain (NCBI)SLC4A10
DMDM Disease mutations57282
Blocks (Seattle)SLC4A10
SuperfamilyQ6U841
Human Protein AtlasENSG00000144290
Peptide AtlasQ6U841
IPIIPI00004944   IPI00746904   IPI00922880   IPI01012251   IPI00924717   IPI00924515   IPI00926117   IPI00925919   IPI00926168   
Protein Interaction databases
DIP (DOE-UCLA)Q6U841
IntAct (EBI)Q6U841
FunCoupENSG00000144290
BioGRIDSLC4A10
STRING (EMBL)SLC4A10
ZODIACSLC4A10
Ontologies - Pathways
QuickGOQ6U841
Ontology : AmiGOinorganic anion exchanger activity  plasma membrane  integral component of plasma membrane  sodium ion transport  chloride transport  nervous system development  anion transmembrane transporter activity  response to light stimulus  post-embryonic development  symporter activity  anion:anion antiporter activity  bicarbonate transport  bicarbonate transport  bicarbonate transport  integral component of membrane  basolateral plasma membrane  pyramidal neuron development  multicellular organism growth  locomotory exploration behavior  neuronal cell body  brain morphogenesis  regulation of intracellular pH  apical dendrite  basilar dendrite  CA3 pyramidal cell dendrite  anion transmembrane transport  hydrogen ion transmembrane transport  
Ontology : EGO-EBIinorganic anion exchanger activity  plasma membrane  integral component of plasma membrane  sodium ion transport  chloride transport  nervous system development  anion transmembrane transporter activity  response to light stimulus  post-embryonic development  symporter activity  anion:anion antiporter activity  bicarbonate transport  bicarbonate transport  bicarbonate transport  integral component of membrane  basolateral plasma membrane  pyramidal neuron development  multicellular organism growth  locomotory exploration behavior  neuronal cell body  brain morphogenesis  regulation of intracellular pH  apical dendrite  basilar dendrite  CA3 pyramidal cell dendrite  anion transmembrane transport  hydrogen ion transmembrane transport  
NDEx NetworkSLC4A10
Atlas of Cancer Signalling NetworkSLC4A10
Wikipedia pathwaysSLC4A10
Orthology - Evolution
OrthoDB57282
GeneTree (enSembl)ENSG00000144290
Phylogenetic Trees/Animal Genes : TreeFamSLC4A10
HOVERGENQ6U841
HOGENOMQ6U841
Homologs : HomoloGeneSLC4A10
Homology/Alignments : Family Browser (UCSC)SLC4A10
Gene fusions - Rearrangements
Fusion : MitelmanANKRD26P1/SLC4A10 [16q11.2/2q24.2]  [t(2;16)(q24;q11)]  
Fusion : MitelmanTRIP12/SLC4A10 [2q36.3/2q24.2]  [t(2;2)(q24;q36)]  
Fusion: TCGATRIP12 2q36.3 SLC4A10 2q24.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC4A10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC4A10
dbVarSLC4A10
ClinVarSLC4A10
1000_GenomesSLC4A10 
Exome Variant ServerSLC4A10
ExAC (Exome Aggregation Consortium)SLC4A10 (select the gene name)
Genetic variants : HAPMAP57282
Genomic Variants (DGV)SLC4A10 [DGVbeta]
DECIPHERSLC4A10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC4A10 
Mutations
ICGC Data PortalSLC4A10 
TCGA Data PortalSLC4A10 
Broad Tumor PortalSLC4A10
OASIS PortalSLC4A10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC4A10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC4A10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch SLC4A10
DgiDB (Drug Gene Interaction Database)SLC4A10
DoCM (Curated mutations)SLC4A10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC4A10 (select a term)
intoGenSLC4A10
Cancer3DSLC4A10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605556   
Orphanet
MedgenSLC4A10
Genetic Testing Registry SLC4A10
NextProtQ6U841 [Medical]
TSGene57282
GENETestsSLC4A10
Target ValidationSLC4A10
Huge Navigator SLC4A10 [HugePedia]
snp3D : Map Gene to Disease57282
BioCentury BCIQSLC4A10
ClinGenSLC4A10 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57282
Chemical/Pharm GKB GenePA37810
Clinical trialSLC4A10
Miscellaneous
canSAR (ICR)SLC4A10 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC4A10
EVEXSLC4A10
GoPubMedSLC4A10
iHOPSLC4A10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:56:13 CEST 2017

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