SLC4A7 (solute carrier family 4 member 7)

2013-04-01  

Identity

HGNC
LOCATION
3p24.1
LOCUSID
ALIAS
NBC2,NBC3,NBCN1,SBC2,SLC4A6
FUSION GENES

Other Information

Locus ID:

NCBI: 9497
MIM: 603353
HGNC: 11033
Ensembl: ENSG00000033867

Variants:

dbSNP: 9497
ClinVar: 9497
TCGA: ENSG00000033867
COSMIC: SLC4A7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000033867ENST00000295736Q9Y6M7
ENSG00000033867ENST00000419036H7C3C4
ENSG00000033867ENST00000425128A0A0A0MST8
ENSG00000033867ENST00000428179C9JRP1
ENSG00000033867ENST00000428386Q9Y6M7
ENSG00000033867ENST00000437179Q9Y6M7
ENSG00000033867ENST00000437266Q9Y6M7
ENSG00000033867ENST00000438530Q9Y6M7
ENSG00000033867ENST00000440156Q9Y6M7
ENSG00000033867ENST00000445684E9PFN4
ENSG00000033867ENST00000446700Q9Y6M7
ENSG00000033867ENST00000454389Q9Y6M7
ENSG00000033867ENST00000455077Q9Y6M7
ENSG00000033867ENST00000457377Q9Y6M7

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Bicarbonate transportersREACTOMER-HSA-425381

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383101862024Antibodies toward Na(+),HCO(3)(-)-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer.0
383101862024Antibodies toward Na(+),HCO(3)(-)-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer.0
370391012023Dynamic localization of the Na+-HCO3- co-transporter NBCn1 to the plasma membrane, centrosomes, spindle and primary cilia.5
371281572023Update on the relationship between the SLC4A7 variant rs4973768 and breast cancer risk: a systematic review and meta-analysis.3
370391012023Dynamic localization of the Na+-HCO3- co-transporter NBCn1 to the plasma membrane, centrosomes, spindle and primary cilia.5
371281572023Update on the relationship between the SLC4A7 variant rs4973768 and breast cancer risk: a systematic review and meta-analysis.3
357724042022The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis.13
357724042022The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis.13
326208472020Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1.7
326208472020Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1.7
297799312018The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification.34
297799312018The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification.34
277846832017The Hypertension Risk Variant Rs820430 Functions as an Enhancer of SLC4A7.11
280877312017Increased NBCn1 expression, Na+/HCO3- co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension.16
280877572017Alternative transcription of sodium/bicarbonate transporter SLC4A7 gene enhanced by single nucleotide polymorphisms.5

Citation

Dessen P

SLC4A7 (solute carrier family 4 member 7)

Atlas Genet Cytogenet Oncol Haematol. 2013-04-01

Online version: http://atlasgeneticsoncology.org/gene/53241/slc4a7