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SLC4A8 (solute carrier family 4, sodium bicarbonate cotransporter, member 8)

Identity

Alias_namessolute carrier family 4, sodium bicarbonate cotransporter, member 8
Alias_symbol (synonym)NBC3
Other aliasNDCBE
HGNC (Hugo) SLC4A8
LocusID (NCBI) 9498
Atlas_Id 73454
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 51818594 and ends at 51909547 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SLC4A8 (12q13.13) / LMBRD1 (6q13)TCTN3 (10q24.1) / SLC4A8 (12q13.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC4A8   11034
Cards
Entrez_Gene (NCBI)SLC4A8  9498  solute carrier family 4, sodium bicarbonate cotransporter, member 8
AliasesNBC3; NDCBE
GeneCards (Weizmann)SLC4A8
Ensembl hg19 (Hinxton)ENSG00000050438 [Gene_View]  chr12:51818594-51909547 [Contig_View]  SLC4A8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000050438 [Gene_View]  chr12:51818594-51909547 [Contig_View]  SLC4A8 [Vega]
ICGC DataPortalENSG00000050438
TCGA cBioPortalSLC4A8
AceView (NCBI)SLC4A8
Genatlas (Paris)SLC4A8
WikiGenes9498
SOURCE (Princeton)SLC4A8
Genetics Home Reference (NIH)SLC4A8
Genomic and cartography
GoldenPath hg19 (UCSC)SLC4A8  -     chr12:51818594-51909547 +  12q13.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SLC4A8  -     12q13.13   [Description]    (hg38-Dec_2013)
EnsemblSLC4A8 - 12q13.13 [CytoView hg19]  SLC4A8 - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBISLC4A8 [Mapview hg19]  SLC4A8 [Mapview hg38]
OMIM605024   
Gene and transcription
Genbank (Entrez)AB018282 AF069512 AF107099 AI377345 AK056222
RefSeq transcript (Entrez)NM_001039960 NM_001258401 NM_001258402 NM_001258403 NM_001267615 NM_004858
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_032675 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)SLC4A8
Cluster EST : UnigeneHs.4749 [ NCBI ]
CGAP (NCI)Hs.4749
Alternative Splicing GalleryENSG00000050438
Gene ExpressionSLC4A8 [ NCBI-GEO ]   SLC4A8 [ EBI - ARRAY_EXPRESS ]   SLC4A8 [ SEEK ]   SLC4A8 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC4A8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9498
GTEX Portal (Tissue expression)SLC4A8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ2Y0W8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ2Y0W8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ2Y0W8
Splice isoforms : SwissVarQ2Y0W8
PhosPhoSitePlusQ2Y0W8
Domains : Interpro (EBI)Band3_cytoplasmic_dom    HCO3_transpt_C    HCO3_transpt_euk    Na/HCO3_transpt    PTrfase/Anion_transptr   
Domain families : Pfam (Sanger)Band_3_cyto (PF07565)    HCO3_cotransp (PF00955)   
Domain families : Pfam (NCBI)pfam07565    pfam00955   
Conserved Domain (NCBI)SLC4A8
DMDM Disease mutations9498
Blocks (Seattle)SLC4A8
SuperfamilyQ2Y0W8
Human Protein AtlasENSG00000050438
Peptide AtlasQ2Y0W8
HPRD05430
IPIIPI00737057   IPI00097856   IPI00184876   IPI00794077   IPI00889606   IPI00889627   IPI00792986   IPI01018917   IPI01010277   IPI01020924   
Protein Interaction databases
DIP (DOE-UCLA)Q2Y0W8
IntAct (EBI)Q2Y0W8
FunCoupENSG00000050438
BioGRIDSLC4A8
STRING (EMBL)SLC4A8
ZODIACSLC4A8
Ontologies - Pathways
QuickGOQ2Y0W8
Ontology : AmiGOinorganic anion exchanger activity  plasma membrane  integral component of plasma membrane  ion transport  sodium:bicarbonate symporter activity  bicarbonate transport  bicarbonate transport  neuronal cell body membrane  sodium ion transmembrane transport  neuron projection  regulation of intracellular pH  transmembrane transport  anion transmembrane transport  
Ontology : EGO-EBIinorganic anion exchanger activity  plasma membrane  integral component of plasma membrane  ion transport  sodium:bicarbonate symporter activity  bicarbonate transport  bicarbonate transport  neuronal cell body membrane  sodium ion transmembrane transport  neuron projection  regulation of intracellular pH  transmembrane transport  anion transmembrane transport  
NDEx NetworkSLC4A8
Atlas of Cancer Signalling NetworkSLC4A8
Wikipedia pathwaysSLC4A8
Orthology - Evolution
OrthoDB9498
GeneTree (enSembl)ENSG00000050438
Phylogenetic Trees/Animal Genes : TreeFamSLC4A8
HOVERGENQ2Y0W8
HOGENOMQ2Y0W8
Homologs : HomoloGeneSLC4A8
Homology/Alignments : Family Browser (UCSC)SLC4A8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC4A8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC4A8
dbVarSLC4A8
ClinVarSLC4A8
1000_GenomesSLC4A8 
Exome Variant ServerSLC4A8
ExAC (Exome Aggregation Consortium)SLC4A8 (select the gene name)
Genetic variants : HAPMAP9498
Genomic Variants (DGV)SLC4A8 [DGVbeta]
DECIPHER (Syndromes)12:51818594-51909547  ENSG00000050438
CONAN: Copy Number AnalysisSLC4A8 
Mutations
ICGC Data PortalSLC4A8 
TCGA Data PortalSLC4A8 
Broad Tumor PortalSLC4A8
OASIS PortalSLC4A8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC4A8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC4A8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch SLC4A8
DgiDB (Drug Gene Interaction Database)SLC4A8
DoCM (Curated mutations)SLC4A8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC4A8 (select a term)
intoGenSLC4A8
Cancer3DSLC4A8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605024   
Orphanet
MedgenSLC4A8
Genetic Testing Registry SLC4A8
NextProtQ2Y0W8 [Medical]
TSGene9498
GENETestsSLC4A8
Huge Navigator SLC4A8 [HugePedia]
snp3D : Map Gene to Disease9498
BioCentury BCIQSLC4A8
ClinGenSLC4A8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9498
Chemical/Pharm GKB GenePA35900
Clinical trialSLC4A8
Miscellaneous
canSAR (ICR)SLC4A8 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC4A8
EVEXSLC4A8
GoPubMedSLC4A8
iHOPSLC4A8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:43:49 CET 2017

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