SLC51B (solute carrier family 51 subunit beta)

2014-11-01  

Identity

HGNC
LOCATION
15q22.31
LOCUSID
ALIAS
OSTB,OSTBETA

Other Information

Locus ID:

NCBI: 123264
MIM: 612085
HGNC: 29956
Ensembl: ENSG00000186198

Variants:

dbSNP: 123264
ClinVar: 123264
TCGA: ENSG00000186198
COSMIC: SLC51B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186198ENST00000334287Q86UW2

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163176842005OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia.90
164239202006Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.86
162695192006The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes.56
162517212006FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.48
127194322003Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta.43
173324732007Protein-protein interactions and membrane localization of the human organic solute transporter.18
184693002008Reduced ileal expression of OSTalpha-OSTbeta in non-obese gallstone disease.14
206498392010Neurosteroid transport by the organic solute transporter OSTα-OSTβ.13
225359582012β-Subunit of the Ostα-Ostβ organic solute transporter is required not only for heterodimerization and trafficking but also for function.9
216910992011Pleiotropic functions of the organic solute transporter Ostα-Ostβ.8

Citation

Dessen P

SLC51B (solute carrier family 51 subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73458/slc51b