SLC5A2 (solute carrier family 5 member 2)

2003-05-01  

Identity

HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
SGLT2
FUSION GENES

Other Information

Locus ID:

NCBI: 6524
MIM: 182381
HGNC: 11037
Ensembl: ENSG00000140675

Variants:

dbSNP: 6524
ClinVar: 6524
TCGA: ENSG00000140675
COSMIC: SLC5A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140675ENST00000330498P31639
ENSG00000140675ENST00000419665P31639
ENSG00000140675ENST00000569576H3BP44

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Hexose transportREACTOMER-HSA-189200
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Na+-dependent glucose transportersREACTOMER-HSA-428808
Inositol transportersREACTOMER-HSA-429593
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
258948292015Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion.127
268617832016Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes.71
209805482011Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2.64
145690972003Molecular analysis of the SGLT2 gene in patients with renal glucosuria.60
290615762017Sodium Glucose Cotransporter-2 Inhibition in Heart Failure: Potential Mechanisms, Clinical Applications, and Summary of Clinical Trials.50
261702832015Functional expression of sodium-glucose transporters in cancer.47
226736162012Regulation of the human Na+-dependent glucose cotransporter hSGLT2.33
285065192017Sodium-Glucose Co-transporters and Their Inhibition: Clinical Physiology.22
186220232008Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion.21
301320322018Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2.21

Citation

Dessen P

SLC5A2 (solute carrier family 5 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42326/slc5a2