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SLC5A2 (solute carrier family 5 member 2)

Identity

Alias_namesSGLT2
solute carrier family 5 (sodium/glucose cotransporter)
Other alias
HGNC (Hugo) SLC5A2
LocusID (NCBI) 6524
Atlas_Id 42326
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 31483118 and ends at 31490770 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SLC5A2 (16p11.2) / IGSF8 (1q23.2)SLC5A2 (16p11.2) / SLC5A2 (16p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC5A2   11037
Cards
Entrez_Gene (NCBI)SLC5A2  6524  solute carrier family 5 member 2
AliasesSGLT2
GeneCards (Weizmann)SLC5A2
Ensembl hg19 (Hinxton)ENSG00000140675 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140675 [Gene_View]  chr16:31483118-31490770 [Contig_View]  SLC5A2 [Vega]
ICGC DataPortalENSG00000140675
TCGA cBioPortalSLC5A2
AceView (NCBI)SLC5A2
Genatlas (Paris)SLC5A2
WikiGenes6524
SOURCE (Princeton)SLC5A2
Genetics Home Reference (NIH)SLC5A2
Genomic and cartography
GoldenPath hg38 (UCSC)SLC5A2  -     chr16:31483118-31490770 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC5A2  -     16p11.2   [Description]    (hg19-Feb_2009)
EnsemblSLC5A2 - 16p11.2 [CytoView hg19]  SLC5A2 - 16p11.2 [CytoView hg38]
Mapping of homologs : NCBISLC5A2 [Mapview hg19]  SLC5A2 [Mapview hg38]
OMIM182381   233100   
Gene and transcription
Genbank (Entrez)AI222550 AK054830 BC131542 M95549
RefSeq transcript (Entrez)NM_003041
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLC5A2
Cluster EST : UnigeneHs.709195 [ NCBI ]
CGAP (NCI)Hs.709195
Alternative Splicing GalleryENSG00000140675
Gene ExpressionSLC5A2 [ NCBI-GEO ]   SLC5A2 [ EBI - ARRAY_EXPRESS ]   SLC5A2 [ SEEK ]   SLC5A2 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC5A2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6524
GTEX Portal (Tissue expression)SLC5A2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31639   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31639  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31639
Splice isoforms : SwissVarP31639
PhosPhoSitePlusP31639
Domaine pattern : Prosite (Expaxy)NA_SOLUT_SYMP_1 (PS00456)    NA_SOLUT_SYMP_2 (PS00457)    NA_SOLUT_SYMP_3 (PS50283)   
Domains : Interpro (EBI)Na/solute_symporter    Na/solute_symporter_CS   
Domain families : Pfam (Sanger)SSF (PF00474)   
Domain families : Pfam (NCBI)pfam00474   
Conserved Domain (NCBI)SLC5A2
DMDM Disease mutations6524
Blocks (Seattle)SLC5A2
SuperfamilyP31639
Human Protein AtlasENSG00000140675
Peptide AtlasP31639
HPRD08919
IPIIPI00012449   IPI00829988   IPI00748751   
Protein Interaction databases
DIP (DOE-UCLA)P31639
IntAct (EBI)P31639
FunCoupENSG00000140675
BioGRIDSLC5A2
STRING (EMBL)SLC5A2
ZODIACSLC5A2
Ontologies - Pathways
QuickGOP31639
Ontology : AmiGOlow-affinity glucose:sodium symporter activity  glucose:sodium symporter activity  plasma membrane  integral component of plasma membrane  carbohydrate metabolic process  transport  sodium ion transport  integral component of membrane  extracellular exosome  glucose transmembrane transport  
Ontology : EGO-EBIlow-affinity glucose:sodium symporter activity  glucose:sodium symporter activity  plasma membrane  integral component of plasma membrane  carbohydrate metabolic process  transport  sodium ion transport  integral component of membrane  extracellular exosome  glucose transmembrane transport  
NDEx NetworkSLC5A2
Atlas of Cancer Signalling NetworkSLC5A2
Wikipedia pathwaysSLC5A2
Orthology - Evolution
OrthoDB6524
GeneTree (enSembl)ENSG00000140675
Phylogenetic Trees/Animal Genes : TreeFamSLC5A2
HOVERGENP31639
HOGENOMP31639
Homologs : HomoloGeneSLC5A2
Homology/Alignments : Family Browser (UCSC)SLC5A2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC5A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC5A2
dbVarSLC5A2
ClinVarSLC5A2
1000_GenomesSLC5A2 
Exome Variant ServerSLC5A2
ExAC (Exome Aggregation Consortium)SLC5A2 (select the gene name)
Genetic variants : HAPMAP6524
Genomic Variants (DGV)SLC5A2 [DGVbeta]
DECIPHERSLC5A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC5A2 
Mutations
ICGC Data PortalSLC5A2 
TCGA Data PortalSLC5A2 
Broad Tumor PortalSLC5A2
OASIS PortalSLC5A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC5A2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC5A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC5A2
DgiDB (Drug Gene Interaction Database)SLC5A2
DoCM (Curated mutations)SLC5A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC5A2 (select a term)
intoGenSLC5A2
Cancer3DSLC5A2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182381    233100   
Orphanet10912   
MedgenSLC5A2
Genetic Testing Registry SLC5A2
NextProtP31639 [Medical]
TSGene6524
GENETestsSLC5A2
Target ValidationSLC5A2
Huge Navigator SLC5A2 [HugePedia]
snp3D : Map Gene to Disease6524
BioCentury BCIQSLC5A2
ClinGenSLC5A2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6524
Chemical/Pharm GKB GenePA35902
Clinical trialSLC5A2
Miscellaneous
canSAR (ICR)SLC5A2 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC5A2
EVEXSLC5A2
GoPubMedSLC5A2
iHOPSLC5A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:14:56 CEST 2017

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