SLC5A4 (solute carrier family 5 member 4)

2014-11-01 Affiliation

Identity

HGNC

SLC5A4

LOCATION

22q12.3

LOCUSID

6527

ALIAS

DJ90G24.4,SAAT1,SGLT3

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6527
MIM: 618633
HGNC: 11039
Ensembl: ENSG00000100191

Variants:

dbSNP: 6527
ClinVar: 6527
TCGA: ENSG00000100191
COSMIC: SLC5A4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100191	ENST00000266086	Q9NY91

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Hexose transport	REACTOME	R-HSA-189200
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366
Na+-dependent glucose transporters	REACTOME	R-HSA-428808
Inositol transporters	REACTOME	R-HSA-429593
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387

References

Pubmed ID	Year	Title	Citations
13130073	2003	A glucose sensor hiding in a family of transporters.	72
16319503	2006	Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression.	19
17705872	2007	Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis.	18
20421923	2010	A single amino acid change converts the sugar sensor SGLT3 into a sugar transporter.	16
17110502	2007	Imino sugars are potent agonists of the human glucose sensor SGLT3.	14
25200297	2014	Metabolic effects of portal vein sensing.	8
22766068	2012	A novel SGLT is expressed in the human kidney.	6
18198291	2008	Protection of muscle membrane excitability during cycling in humans: a role for SGLT3?	0
30286162	2018	Functional analysis of a triplet deletion in the gene encoding the sodium glucose transporter 3, a potential risk factor for ADHD.	0

Citation

Dessen P

SLC5A4 (solute carrier family 5 member 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73464/slc5a4