SLC6A15 (solute carrier family 6 member 15)

2014-11-01  

Identity

HGNC
LOCATION
12q21.31
LOCUSID
ALIAS
NTT73,SBAT1,V7-3,hv7-3
FUSION GENES

Other Information

Locus ID:

NCBI: 55117
MIM: 607971
HGNC: 13621
Ensembl: ENSG00000072041

Variants:

dbSNP: 55117
ClinVar: 55117
TCGA: ENSG00000072041
COSMIC: SLC6A15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072041ENST00000266682Q9H2J7
ENSG00000072041ENST00000309283F8WJN6
ENSG00000072041ENST00000450363Q9H2J7
ENSG00000072041ENST00000549540F8VSG1
ENSG00000072041ENST00000551010S4R439
ENSG00000072041ENST00000551612F8VX16
ENSG00000072041ENST00000552192Q9H2J7

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Na+/Cl- dependent neurotransmitter transportersREACTOMER-HSA-442660

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
215216122011The neuronal transporter gene SLC6A15 confers risk to major depression.67
162267212005Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain.30
191474952009Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport.16
224756222013A variant of the neuronal amino acid transporter SLC6A15 is associated with ACTH and cortisol responses and cognitive performance in unipolar depression.15
238208372013SLC6A15 rs1545843 and depression: implications from brain imaging data.5
277237672016Effects of a Polymorphism of the Neuronal Amino Acid Transporter SLC6A15 Gene on Structural Integrity of White Matter Tracts in Major Depressive Disorder.5
283201362017Association between gene polymorphism and depression in Parkinson's disease: A case-control study.2
309132802019Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes indicates association with insulin resistance of metabolic syndrome and relationship with branched chain amino acid metabolism or regulation.1
289150822017A Combined Study of SLC6A15 Gene Polymorphism and the Resting-State Functional Magnetic Resonance Imaging in First-Episode Drug-Naive Major Depressive Disorder.0

Citation

Dessen P

SLC6A15 (solute carrier family 6 member 15)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73471/slc6a15