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SLC6A3 (solute carrier family 6 member 3)

Identity

Alias_namesDAT1
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
dopamine transporter 1
solute carrier family 6 (neurotransmitter transporter), member 3
Alias_symbol (synonym)DAT
Other aliasPKDYS
HGNC (Hugo) SLC6A3
LocusID (NCBI) 6531
Atlas_Id 43591
Location 5p15.33  [Link to chromosome band 5p15]
Location_base_pair Starts at 1392790 and ends at 1445428 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC6A3   11049
Cards
Entrez_Gene (NCBI)SLC6A3  6531  solute carrier family 6 member 3
AliasesDAT; DAT1; PKDYS
GeneCards (Weizmann)SLC6A3
Ensembl hg19 (Hinxton)ENSG00000142319 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142319 [Gene_View]  chr5:1392790-1445428 [Contig_View]  SLC6A3 [Vega]
ICGC DataPortalENSG00000142319
TCGA cBioPortalSLC6A3
AceView (NCBI)SLC6A3
Genatlas (Paris)SLC6A3
WikiGenes6531
SOURCE (Princeton)SLC6A3
Genetics Home Reference (NIH)SLC6A3
Genomic and cartography
GoldenPath hg38 (UCSC)SLC6A3  -     chr5:1392790-1445428 -  5p15.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC6A3  -     5p15.33   [Description]    (hg19-Feb_2009)
EnsemblSLC6A3 - 5p15.33 [CytoView hg19]  SLC6A3 - 5p15.33 [CytoView hg38]
Mapping of homologs : NCBISLC6A3 [Mapview hg19]  SLC6A3 [Mapview hg38]
OMIM126455   188890   613135   
Gene and transcription
Genbank (Entrez)AI586989 AK310589 BC132977 BC133003 EF174603
RefSeq transcript (Entrez)NM_001044
RefSeq genomic (Entrez)NC_000005 NC_018916 NG_015885 NT_187547
Consensus coding sequences : CCDS (NCBI)SLC6A3
Cluster EST : UnigeneHs.406 [ NCBI ]
CGAP (NCI)Hs.406
Alternative Splicing GalleryENSG00000142319
Gene ExpressionSLC6A3 [ NCBI-GEO ]   SLC6A3 [ EBI - ARRAY_EXPRESS ]   SLC6A3 [ SEEK ]   SLC6A3 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC6A3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6531
GTEX Portal (Tissue expression)SLC6A3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01959   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01959  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01959
Splice isoforms : SwissVarQ01959
PhosPhoSitePlusQ01959
Domaine pattern : Prosite (Expaxy)NA_NEUROTRAN_SYMP_1 (PS00610)    NA_NEUROTRAN_SYMP_2 (PS00754)    NA_NEUROTRAN_SYMP_3 (PS50267)   
Domains : Interpro (EBI)Na/ntran_symport    Na/ntran_symport_dopamine   
Domain families : Pfam (Sanger)SNF (PF00209)   
Domain families : Pfam (NCBI)pfam00209   
Conserved Domain (NCBI)SLC6A3
DMDM Disease mutations6531
Blocks (Seattle)SLC6A3
SuperfamilyQ01959
Human Protein AtlasENSG00000142319
Peptide AtlasQ01959
HPRD00543
IPIIPI00219765   IPI00874158   IPI00981796   IPI00981219   
Protein Interaction databases
DIP (DOE-UCLA)Q01959
IntAct (EBI)Q01959
FunCoupENSG00000142319
BioGRIDSLC6A3
STRING (EMBL)SLC6A3
ZODIACSLC6A3
Ontologies - Pathways
QuickGOQ01959
Ontology : AmiGOprotease binding  receptor binding  dopamine transmembrane transporter activity  dopamine:sodium symporter activity  protein binding  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  aging  lactation  sensory perception of smell  locomotory behavior  drug binding  monoamine transmembrane transporter activity  monoamine transmembrane transporter activity  cell surface  response to iron ion  monoamine transport  dopamine transport  integral component of membrane  flotillin complex  adenohypophysis development  axon  protein complex binding  response to nicotine  dopamine binding  positive regulation of multicellular organism growth  regulation of dopamine metabolic process  neurotransmitter biosynthetic process  response to cocaine  dopamine biosynthetic process  dopamine catabolic process  response to drug  neuron projection  neuronal cell body  membrane raft  response to ethanol  metal ion binding  protein N-terminus binding  dopamine uptake involved in synaptic transmission  response to cAMP  protein phosphatase 2A binding  prepulse inhibition  ammonium transmembrane transport  dopamine uptake  presynapse  
Ontology : EGO-EBIprotease binding  receptor binding  dopamine transmembrane transporter activity  dopamine:sodium symporter activity  protein binding  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  aging  lactation  sensory perception of smell  locomotory behavior  drug binding  monoamine transmembrane transporter activity  monoamine transmembrane transporter activity  cell surface  response to iron ion  monoamine transport  dopamine transport  integral component of membrane  flotillin complex  adenohypophysis development  axon  protein complex binding  response to nicotine  dopamine binding  positive regulation of multicellular organism growth  regulation of dopamine metabolic process  neurotransmitter biosynthetic process  response to cocaine  dopamine biosynthetic process  dopamine catabolic process  response to drug  neuron projection  neuronal cell body  membrane raft  response to ethanol  metal ion binding  protein N-terminus binding  dopamine uptake involved in synaptic transmission  response to cAMP  protein phosphatase 2A binding  prepulse inhibition  ammonium transmembrane transport  dopamine uptake  presynapse  
Pathways : KEGGDopaminergic synapse    Parkinson's disease    Cocaine addiction    Amphetamine addiction    Alcoholism   
NDEx NetworkSLC6A3
Atlas of Cancer Signalling NetworkSLC6A3
Wikipedia pathwaysSLC6A3
Orthology - Evolution
OrthoDB6531
GeneTree (enSembl)ENSG00000142319
Phylogenetic Trees/Animal Genes : TreeFamSLC6A3
HOVERGENQ01959
HOGENOMQ01959
Homologs : HomoloGeneSLC6A3
Homology/Alignments : Family Browser (UCSC)SLC6A3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC6A3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC6A3
dbVarSLC6A3
ClinVarSLC6A3
1000_GenomesSLC6A3 
Exome Variant ServerSLC6A3
ExAC (Exome Aggregation Consortium)SLC6A3 (select the gene name)
Genetic variants : HAPMAP6531
Genomic Variants (DGV)SLC6A3 [DGVbeta]
DECIPHERSLC6A3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC6A3 
Mutations
ICGC Data PortalSLC6A3 
TCGA Data PortalSLC6A3 
Broad Tumor PortalSLC6A3
OASIS PortalSLC6A3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC6A3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC6A3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch SLC6A3
DgiDB (Drug Gene Interaction Database)SLC6A3
DoCM (Curated mutations)SLC6A3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC6A3 (select a term)
intoGenSLC6A3
Cancer3DSLC6A3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM126455    188890    613135   
Orphanet19264   
MedgenSLC6A3
Genetic Testing Registry SLC6A3
NextProtQ01959 [Medical]
TSGene6531
GENETestsSLC6A3
Target ValidationSLC6A3
Huge Navigator SLC6A3 [HugePedia]
snp3D : Map Gene to Disease6531
BioCentury BCIQSLC6A3
ClinGenSLC6A3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6531
Chemical/Pharm GKB GenePA311
Clinical trialSLC6A3
Miscellaneous
canSAR (ICR)SLC6A3 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC6A3
EVEXSLC6A3
GoPubMedSLC6A3
iHOPSLC6A3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:56:17 CEST 2017

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