SLC6A6 (solute carrier family 6 member 6)

2009-05-01  

Identity

HGNC
LOCATION
3p25.1
LOCUSID
ALIAS
TAUT
FUSION GENES

Other Information

Locus ID:

NCBI: 6533
MIM: 186854
HGNC: 11052
Ensembl: ENSG00000131389

Variants:

dbSNP: 6533
ClinVar: 6533
TCGA: ENSG00000131389
COSMIC: SLC6A6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131389ENST00000452151H7C1B9
ENSG00000131389ENST00000452775C9JPV1
ENSG00000131389ENST00000610642A0A087WZ59
ENSG00000131389ENST00000613060A0A087WY96
ENSG00000131389ENST00000618278A0A087WYN0
ENSG00000131389ENST00000621751P31641
ENSG00000131389ENST00000622176A0A087WYY8
ENSG00000131389ENST00000622186P31641
ENSG00000131389ENST00000649500A0A087WZ59

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Na+/Cl- dependent neurotransmitter transportersREACTOMER-HSA-442660

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190749662009Taurine uptake across the human intestinal brush-border membrane is via two transporters: H+-coupled PAT1 (SLC36A1) and Na+- and Cl(-)-dependent TauT (SLC6A6).23
196025792009Oxidative stress and dysregulation of the taurine transporter in high-glucose-exposed human Schwann cells: implications for pathogenesis of diabetic neuropathy.23
151660082004Human placental taurine transporter in uncomplicated and IUGR pregnancies: cellular localization, protein expression, and regulation.21
194236932009Functional TauT protects against acute kidney injury.19
235191282013Taurine transport in human placental trophoblast is important for regulation of cell differentiation and survival.14
121634982002Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells.11
262067262015Intrinsic carnosine metabolism in the human kidney.11
233928732013Reduced placental taurine transporter (TauT) activity in pregnancies complicated by pre-eclampsia and maternal obesity.8
120624162002Tumor necrosis factor alpha stimulates taurine uptake and transporter gene expression in human intestinal Caco-2 cells.7
163561172005Regulation of the human taurine transporter by oxidative stress in retinal pigment epithelial cells stably transformed to overexpress aldose reductase.7

Citation

Dessen P

SLC6A6 (solute carrier family 6 member 6)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50889/slc6a6