SLC6A6 (solute carrier family 6 member 6)

2009-05-01  

Identity

HGNC
LOCATION
3p25.1
LOCUSID
ALIAS
TAUT
FUSION GENES

Other Information

Locus ID:

NCBI: 6533
MIM: 186854
HGNC: 11052
Ensembl: ENSG00000131389

Variants:

dbSNP: 6533
ClinVar: 6533
TCGA: ENSG00000131389
COSMIC: SLC6A6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131389ENST00000452151H7C1B9
ENSG00000131389ENST00000452775C9JPV1
ENSG00000131389ENST00000610642A0A087WZ59
ENSG00000131389ENST00000613060A0A087WY96
ENSG00000131389ENST00000618278A0A087WYN0
ENSG00000131389ENST00000621751P31641
ENSG00000131389ENST00000622176A0A087WYY8
ENSG00000131389ENST00000622186P31641
ENSG00000131389ENST00000649500A0A087WZ59

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Na+/Cl- dependent neurotransmitter transportersREACTOMER-HSA-442660

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
321144382020Protein kinases as regulators of osmolyte accumulation under stress conditions: An overview.0
327051972020Significance of taurine transporter (TauT) in homeostasis and its layers of regulation (Review).20
321144382020Protein kinases as regulators of osmolyte accumulation under stress conditions: An overview.0
327051972020Significance of taurine transporter (TauT) in homeostasis and its layers of regulation (Review).20
307675022019Elevated SLC6A6 expression drives tumorigenesis and affects clinical outcomes in gastric cancer.8
313450612019Biallelic mutation of human SLC6A6 encoding the taurine transporter TAUT is linked to early retinal degeneration.27
307675022019Elevated SLC6A6 expression drives tumorigenesis and affects clinical outcomes in gastric cancer.8
313450612019Biallelic mutation of human SLC6A6 encoding the taurine transporter TAUT is linked to early retinal degeneration.27
269556422016Taurine Transporter Gene Expression in Mononuclear Blood Cells of Type 1 Diabetes Patients.3
269556422016Taurine Transporter Gene Expression in Mononuclear Blood Cells of Type 1 Diabetes Patients.3
255012782015Chondrocytic cells express the taurine transporter on their plasma membrane and regulate its expression under anisotonic conditions.3
262067262015Intrinsic carnosine metabolism in the human kidney.26
255012782015Chondrocytic cells express the taurine transporter on their plasma membrane and regulate its expression under anisotonic conditions.3
262067262015Intrinsic carnosine metabolism in the human kidney.26
248426062014Neurotransmitter transporter family including SLC6A6 and SLC6A13 contributes to the 5-aminolevulinic acid (ALA)-induced accumulation of protoporphyrin IX and photodamage, through uptake of ALA by cancerous cells.15

Citation

Dessen P

SLC6A6 (solute carrier family 6 member 6)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50889/slc6a6