Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SLC7A11 (solute carrier family 7 member 11)

Identity

Alias_namessolute carrier family 7 (anionic amino acid transporter light chain
Alias_symbol (synonym)xCT
Other aliasCCBR1
HGNC (Hugo) SLC7A11
LocusID (NCBI) 23657
Atlas_Id 50348
Location 4q28.3  [Link to chromosome band 4q28]
Location_base_pair Starts at 138164094 and ends at 138242349 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC7A11   11059
Cards
Entrez_Gene (NCBI)SLC7A11  23657  solute carrier family 7 member 11
AliasesCCBR1; xCT
GeneCards (Weizmann)SLC7A11
Ensembl hg19 (Hinxton)ENSG00000151012 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151012 [Gene_View]  chr4:138164094-138242349 [Contig_View]  SLC7A11 [Vega]
ICGC DataPortalENSG00000151012
TCGA cBioPortalSLC7A11
AceView (NCBI)SLC7A11
Genatlas (Paris)SLC7A11
WikiGenes23657
SOURCE (Princeton)SLC7A11
Genetics Home Reference (NIH)SLC7A11
Genomic and cartography
GoldenPath hg38 (UCSC)SLC7A11  -     chr4:138164094-138242349 -  4q28.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC7A11  -     4q28.3   [Description]    (hg19-Feb_2009)
EnsemblSLC7A11 - 4q28.3 [CytoView hg19]  SLC7A11 - 4q28.3 [CytoView hg38]
Mapping of homologs : NCBISLC7A11 [Mapview hg19]  SLC7A11 [Mapview hg38]
OMIM607933   
Gene and transcription
Genbank (Entrez)AB026891 AB040875 AF200708 AF252872 AJ277882
RefSeq transcript (Entrez)NM_014331
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLC7A11
Cluster EST : UnigeneHs.390594 [ NCBI ]
CGAP (NCI)Hs.390594
Alternative Splicing GalleryENSG00000151012
Gene ExpressionSLC7A11 [ NCBI-GEO ]   SLC7A11 [ EBI - ARRAY_EXPRESS ]   SLC7A11 [ SEEK ]   SLC7A11 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC7A11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23657
GTEX Portal (Tissue expression)SLC7A11
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UPY5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UPY5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UPY5
Splice isoforms : SwissVarQ9UPY5
PhosPhoSitePlusQ9UPY5
Domains : Interpro (EBI)AA/rel_permease1    L_AA_transporter   
Domain families : Pfam (Sanger)AA_permease_2 (PF13520)   
Domain families : Pfam (NCBI)pfam13520   
Conserved Domain (NCBI)SLC7A11
DMDM Disease mutations23657
Blocks (Seattle)SLC7A11
SuperfamilyQ9UPY5
Human Protein AtlasENSG00000151012
Peptide AtlasQ9UPY5
HPRD09720
IPIIPI00010474   IPI00967523   
Protein Interaction databases
DIP (DOE-UCLA)Q9UPY5
IntAct (EBI)Q9UPY5
FunCoupENSG00000151012
BioGRIDSLC7A11
STRING (EMBL)SLC7A11
ZODIACSLC7A11
Ontologies - Pathways
QuickGOQ9UPY5
Ontology : AmiGOprotein binding  rough endoplasmic reticulum  cytoskeleton  plasma membrane  integral component of plasma membrane  amino acid transport  response to oxidative stress  brain development  response to toxic substance  cell surface  cystine:glutamate antiporter activity  integral component of membrane  response to nicotine  leukocyte migration  lens fiber cell differentiation  platelet aggregation  L-glutamate transmembrane transport  
Ontology : EGO-EBIprotein binding  rough endoplasmic reticulum  cytoskeleton  plasma membrane  integral component of plasma membrane  amino acid transport  response to oxidative stress  brain development  response to toxic substance  cell surface  cystine:glutamate antiporter activity  integral component of membrane  response to nicotine  leukocyte migration  lens fiber cell differentiation  platelet aggregation  L-glutamate transmembrane transport  
NDEx NetworkSLC7A11
Atlas of Cancer Signalling NetworkSLC7A11
Wikipedia pathwaysSLC7A11
Orthology - Evolution
OrthoDB23657
GeneTree (enSembl)ENSG00000151012
Phylogenetic Trees/Animal Genes : TreeFamSLC7A11
HOVERGENQ9UPY5
HOGENOMQ9UPY5
Homologs : HomoloGeneSLC7A11
Homology/Alignments : Family Browser (UCSC)SLC7A11
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC7A11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC7A11
dbVarSLC7A11
ClinVarSLC7A11
1000_GenomesSLC7A11 
Exome Variant ServerSLC7A11
ExAC (Exome Aggregation Consortium)SLC7A11 (select the gene name)
Genetic variants : HAPMAP23657
Genomic Variants (DGV)SLC7A11 [DGVbeta]
DECIPHERSLC7A11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC7A11 
Mutations
ICGC Data PortalSLC7A11 
TCGA Data PortalSLC7A11 
Broad Tumor PortalSLC7A11
OASIS PortalSLC7A11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC7A11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC7A11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC7A11
DgiDB (Drug Gene Interaction Database)SLC7A11
DoCM (Curated mutations)SLC7A11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC7A11 (select a term)
intoGenSLC7A11
Cancer3DSLC7A11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607933   
Orphanet
MedgenSLC7A11
Genetic Testing Registry SLC7A11
NextProtQ9UPY5 [Medical]
TSGene23657
GENETestsSLC7A11
Target ValidationSLC7A11
Huge Navigator SLC7A11 [HugePedia]
snp3D : Map Gene to Disease23657
BioCentury BCIQSLC7A11
ClinGenSLC7A11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23657
Chemical/Pharm GKB GenePA35919
Clinical trialSLC7A11
Miscellaneous
canSAR (ICR)SLC7A11 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC7A11
EVEXSLC7A11
GoPubMedSLC7A11
iHOPSLC7A11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:56:18 CEST 2017

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