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SLC7A5 (solute carrier family 7 member 5)

Identity

Alias (NCBI)4F2LC
CD98
D16S469E
E16
LAT1
MPE16
HGNC (Hugo) SLC7A5
HGNC Alias symbLAT1
E16
D16S469E
MPE16
CD98
HGNC Previous namesolute carrier family 7 (amino acid transporter light chain, L system), member 5
LocusID (NCBI) 8140
Atlas_Id 42327
Location 16q24.2  [Link to chromosome band 16q24]
Location_base_pair Starts at 87830023 and ends at 87869507 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BANP (16q24.2) / SLC7A5 (16q24.2)SLC7A5 (16q24.2) / CA5A (16q24.2)SLC7A5 (16q24.2) / HLA-DPB1 (6p21.32)
SLC7A5 (16q24.2) / KDM6A (Xp11.3)SLC7A5 (16q24.2) / ZNF76 (6p21.31)ZFPM1 (16q24.2) / SLC7A5 (16q24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(16;22)(q24;q13) PIM3/SLC7A5


External links

 

Nomenclature
HGNC (Hugo)SLC7A5   11063
Cards
Entrez_Gene (NCBI)SLC7A5    solute carrier family 7 member 5
Aliases4F2LC; CD98; D16S469E; E16; 
LAT1; MPE16
GeneCards (Weizmann)SLC7A5
Ensembl hg19 (Hinxton)ENSG00000103257 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103257 [Gene_View]  ENSG00000103257 [Sequence]  chr16:87830023-87869507 [Contig_View]  SLC7A5 [Vega]
ICGC DataPortalENSG00000103257
TCGA cBioPortalSLC7A5
AceView (NCBI)SLC7A5
Genatlas (Paris)SLC7A5
SOURCE (Princeton)SLC7A5
Genetics Home Reference (NIH)SLC7A5
Genomic and cartography
GoldenPath hg38 (UCSC)SLC7A5  -     chr16:87830023-87869507 -  16q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC7A5  -     16q24.2   [Description]    (hg19-Feb_2009)
GoldenPathSLC7A5 - 16q24.2 [CytoView hg19]  SLC7A5 - 16q24.2 [CytoView hg38]
ImmunoBaseENSG00000103257
Genome Data Viewer NCBISLC7A5 [Mapview hg19]  
OMIM600182   
Gene and transcription
Genbank (Entrez)AB017908 AB018009 AB018542 AF077866 AF104032
RefSeq transcript (Entrez)NM_003486
Consensus coding sequences : CCDS (NCBI)SLC7A5
Gene ExpressionSLC7A5 [ NCBI-GEO ]   SLC7A5 [ EBI - ARRAY_EXPRESS ]   SLC7A5 [ SEEK ]   SLC7A5 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC7A5 [ Firebrowse - Broad ]
GenevisibleExpression of SLC7A5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8140
GTEX Portal (Tissue expression)SLC7A5
Human Protein AtlasENSG00000103257-SLC7A5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01650   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01650  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01650
PhosPhoSitePlusQ01650
Domains : Interpro (EBI)AA/rel_permease1    L_AA_transporter   
Domain families : Pfam (Sanger)AA_permease_2 (PF13520)   
Domain families : Pfam (NCBI)pfam13520   
Conserved Domain (NCBI)SLC7A5
PDB (RSDB)6IRS    6IRT    6JMQ   
PDB Europe6IRS    6IRT    6JMQ   
PDB (PDBSum)6IRS    6IRT    6JMQ   
PDB (IMB)6IRS    6IRT    6JMQ   
Structural Biology KnowledgeBase6IRS    6IRT    6JMQ   
SCOP (Structural Classification of Proteins)6IRS    6IRT    6JMQ   
CATH (Classification of proteins structures)6IRS    6IRT    6JMQ   
SuperfamilyQ01650
AlphaFold pdb e-kbQ01650   
Human Protein Atlas [tissue]ENSG00000103257-SLC7A5 [tissue]
HPRD02552
Protein Interaction databases
DIP (DOE-UCLA)Q01650
IntAct (EBI)Q01650
BioGRIDSLC7A5
STRING (EMBL)SLC7A5
ZODIACSLC7A5
Ontologies - Pathways
QuickGOQ01650
Ontology : AmiGOpositive regulation of cytokine production involved in immune response  amino acid transmembrane transport  protein binding  lysosomal membrane  cytosol  plasma membrane  plasma membrane  basal plasma membrane  negative regulation of gene expression  amino acid transmembrane transporter activity  amino acid transmembrane transporter activity  amino acid transmembrane transporter activity  aromatic amino acid transmembrane transporter activity  neutral amino acid transmembrane transporter activity  neutral amino acid transmembrane transporter activity  L-amino acid transmembrane transporter activity  L-leucine transmembrane transporter activity  L-leucine transmembrane transporter activity  L-tryptophan transmembrane transporter activity  thyroid hormone transmembrane transporter activity  neutral amino acid transport  phenylalanine transport  membrane  integral component of membrane  basolateral plasma membrane  apical plasma membrane  apical plasma membrane  microvillus membrane  positive regulation of interferon-gamma production  positive regulation of interleukin-17 production  positive regulation of interleukin-4 production  peptide antigen binding  xenobiotic transport  intracellular membrane-bounded organelle  leukocyte migration  extracellular exosome  thyroid hormone transport  amino acid import across plasma membrane  amino acid import across plasma membrane  amino acid import across plasma membrane  external side of apical plasma membrane  leucine import across plasma membrane  leucine import across plasma membrane  transport across blood-brain barrier  L-alpha-amino acid transmembrane transport  L-leucine import across plasma membrane  L-leucine import across plasma membrane  L-tryptophan transmembrane transport  amino acid transport complex  
Ontology : EGO-EBIpositive regulation of cytokine production involved in immune response  amino acid transmembrane transport  protein binding  lysosomal membrane  cytosol  plasma membrane  plasma membrane  basal plasma membrane  negative regulation of gene expression  amino acid transmembrane transporter activity  amino acid transmembrane transporter activity  amino acid transmembrane transporter activity  aromatic amino acid transmembrane transporter activity  neutral amino acid transmembrane transporter activity  neutral amino acid transmembrane transporter activity  L-amino acid transmembrane transporter activity  L-leucine transmembrane transporter activity  L-leucine transmembrane transporter activity  L-tryptophan transmembrane transporter activity  thyroid hormone transmembrane transporter activity  neutral amino acid transport  phenylalanine transport  membrane  integral component of membrane  basolateral plasma membrane  apical plasma membrane  apical plasma membrane  microvillus membrane  positive regulation of interferon-gamma production  positive regulation of interleukin-17 production  positive regulation of interleukin-4 production  peptide antigen binding  xenobiotic transport  intracellular membrane-bounded organelle  leukocyte migration  extracellular exosome  thyroid hormone transport  amino acid import across plasma membrane  amino acid import across plasma membrane  amino acid import across plasma membrane  external side of apical plasma membrane  leucine import across plasma membrane  leucine import across plasma membrane  transport across blood-brain barrier  L-alpha-amino acid transmembrane transport  L-leucine import across plasma membrane  L-leucine import across plasma membrane  L-tryptophan transmembrane transport  amino acid transport complex  
NDEx NetworkSLC7A5
Atlas of Cancer Signalling NetworkSLC7A5
Wikipedia pathwaysSLC7A5
Orthology - Evolution
OrthoDB8140
GeneTree (enSembl)ENSG00000103257
Phylogenetic Trees/Animal Genes : TreeFamSLC7A5
Homologs : HomoloGeneSLC7A5
Homology/Alignments : Family Browser (UCSC)SLC7A5
Gene fusions - Rearrangements
Fusion Cancer (Beijing)SLC7A5 [16q24.2]  -  HLA-DPB1 [6p21.32]  [FUSC000117]
Fusion : QuiverSLC7A5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC7A5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC7A5
dbVarSLC7A5
ClinVarSLC7A5
MonarchSLC7A5
1000_GenomesSLC7A5 
Exome Variant ServerSLC7A5
GNOMAD BrowserENSG00000103257
Varsome BrowserSLC7A5
ACMGSLC7A5 variants
VarityQ01650
Genomic Variants (DGV)SLC7A5 [DGVbeta]
DECIPHERSLC7A5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC7A5 
Mutations
ICGC Data PortalSLC7A5 
TCGA Data PortalSLC7A5 
Broad Tumor PortalSLC7A5
OASIS PortalSLC7A5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC7A5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSLC7A5
Mutations and Diseases : HGMDSLC7A5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSLC7A5
DgiDB (Drug Gene Interaction Database)SLC7A5
DoCM (Curated mutations)SLC7A5
CIViC (Clinical Interpretations of Variants in Cancer)SLC7A5
Cancer3DSLC7A5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600182   
Orphanet
DisGeNETSLC7A5
MedgenSLC7A5
Genetic Testing Registry SLC7A5
NextProtQ01650 [Medical]
GENETestsSLC7A5
Target ValidationSLC7A5
Huge Navigator SLC7A5 [HugePedia]
ClinGenSLC7A5
Clinical trials, drugs, therapy
MyCancerGenomeSLC7A5
Protein Interactions : CTDSLC7A5
Pharm GKB GenePA35923
PharosQ01650
Clinical trialSLC7A5
Miscellaneous
canSAR (ICR)SLC7A5
HarmonizomeSLC7A5
DataMed IndexSLC7A5
Probes
Litterature
PubMed218 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSLC7A5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:31:59 CEST 2021

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