SLC7A5 (solute carrier family 7 member 5)

2003-08-01  

Identity

HGNC
SLC7A5
LOCATION
16q24.2
LOCUSID
8140
ALIAS
4F2LC,CD98,D16S469E,E16,LAT1,MPE16
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8140
MIM: 600182
HGNC: 11063
Ensembl: ENSG00000103257

Variants:

dbSNP: 8140
ClinVar: 8140
TCGA: ENSG00000103257
COSMIC: SLC7A5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103257ENST00000261622Q01650
ENSG00000103257ENST00000565644A0A0C4DGL4

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
mTOR signaling pathwayKEGGhsa04150
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Basigin interactionsREACTOMER-HSA-210991
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Tryptophan catabolismREACTOMER-HSA-71240
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444985Multiple MyelomaDiseaseClinicalAnnotationassociatedPD
PA450354melphalanChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
191210872009L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer.64
231032532012HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5.58
164963792006L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors.56
182531162008Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer.56
279120582016Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder.54
220773142012Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis.48
259985672015LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation.46
190187762008l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms.43
200913332010Correlation of L-methyl-11C-methionine (MET) uptake with L-type amino acid transporter 1 in human gliomas.42
214392832011miR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5.42

Citation

Dessen P

SLC7A5 (solute carrier family 7 member 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42327/slc7a5