Identity
HGNC
LOCATION
16q24.2
LOCUSID
ALIAS
4F2LC,CD98,D16S469E,E16,LAT1,MPE16
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8140
MIM: 600182
HGNC: 11063
Ensembl: ENSG00000103257
Variants:
dbSNP: 8140
ClinVar: 8140
TCGA: ENSG00000103257
COSMIC: SLC7A5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000103257 | ENST00000261622 | Q01650 |
| ENSG00000103257 | ENST00000565644 | A0A0C4DGL4 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA444985 | Multiple Myeloma | Disease | ClinicalAnnotation | associated | PD | ||
| PA450354 | melphalan | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38556586 | 2024 | Fat mass and obesity-associated protein (FTO) mediated m(6)A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay. | 1 |
| 38660848 | 2024 | [Effect of L-Type Amino Acid Transporter 1 Expression on Clinicopathological Features and Prognosis of Non-Hodgkin's Lymphoma]. | 0 |
| 38556586 | 2024 | Fat mass and obesity-associated protein (FTO) mediated m(6)A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay. | 1 |
| 38660848 | 2024 | [Effect of L-Type Amino Acid Transporter 1 Expression on Clinicopathological Features and Prognosis of Non-Hodgkin's Lymphoma]. | 0 |
| 36371738 | 2023 | Correlation between the expression of LAT1 in cancer cells and the potential efficacy of boron neutron capture therapy. | 5 |
| 36653319 | 2023 | CD98 defines a metabolically flexible, proinflammatory subset of low-density neutrophils in systemic lupus erythematosus. | 2 |
| 36768934 | 2023 | Association of High LAT1 Expression with Poor Prognosis and Recurrence in Colorectal Cancer Patients Treated with Oxaliplatin-Based Adjuvant Chemotherapy. | 2 |
| 37164714 | 2023 | Impact of L-type amino acid transporter 1 on intrahepatic cholangiocarcinoma. | 0 |
| 37728471 | 2023 | CD98 expression can be a predictive factor of resistance to radiotherapy in head and neck squamous cell carcinoma. | 0 |
| 37731509 | 2023 | Targeting glutamine metabolic reprogramming of SLC7A5 enhances the efficacy of anti-PD-1 in triple-negative breast cancer. | 5 |
| 37861075 | 2023 | Overexpression of the LAT1 in primary human trophoblast cells increases the uptake of essential amino acids and activates mTOR signaling. | 1 |
| 37953589 | 2023 | MicroRNA-626 inhibits mTOR pathways activity of retinal pigment epithelial cells by targeting SLC7A5 in human ARPE-19 Cells. | 0 |
| 36371738 | 2023 | Correlation between the expression of LAT1 in cancer cells and the potential efficacy of boron neutron capture therapy. | 5 |
| 36653319 | 2023 | CD98 defines a metabolically flexible, proinflammatory subset of low-density neutrophils in systemic lupus erythematosus. | 2 |
| 36768934 | 2023 | Association of High LAT1 Expression with Poor Prognosis and Recurrence in Colorectal Cancer Patients Treated with Oxaliplatin-Based Adjuvant Chemotherapy. | 2 |
Citation
Dessen P
SLC7A5 (solute carrier family 7 member 5)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/42327/slc7a5
