Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SLC7A6 (solute carrier family 7 member 6)

Identity

Alias_namessolute carrier family 7 (amino acid transporter light chain
Alias_symbol (synonym)y??2
KIAA0245
LAT3
LAT-2
Other aliasy+LAT-2
HGNC (Hugo) SLC7A6
LocusID (NCBI) 9057
Atlas_Id 52642
Location 16q22.1  [Link to chromosome band 16q22]
Location_base_pair Starts at 68264516 and ends at 68301823 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ESRP2 (16q22.1) / SLC7A6 (16q22.1)HSPA8 (11q24.1) / SLC7A6 (16q22.1)RANBP10 (16q22.1) / SLC7A6 (16q22.1)
SLC7A6 (16q22.1) / GRXCR1 (4p13)SLC7A6 (16q22.1) / NFATC3 (16q22.1)ESRP2 16q22.1 / SLC7A6 16q22.1
RANBP10 16q22.1 / SLC7A6 16q22.1SLC7A6 16q22.1 / GRXCR1 4p13SLC7A6 16q22.1 / NFATC3 16q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC7A6   11064
Cards
Entrez_Gene (NCBI)SLC7A6  9057  solute carrier family 7 member 6
AliasesLAT-2; LAT3; y+LAT-2
GeneCards (Weizmann)SLC7A6
Ensembl hg19 (Hinxton)ENSG00000103064 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103064 [Gene_View]  chr16:68264516-68301823 [Contig_View]  SLC7A6 [Vega]
ICGC DataPortalENSG00000103064
TCGA cBioPortalSLC7A6
AceView (NCBI)SLC7A6
Genatlas (Paris)SLC7A6
WikiGenes9057
SOURCE (Princeton)SLC7A6
Genetics Home Reference (NIH)SLC7A6
Genomic and cartography
GoldenPath hg38 (UCSC)SLC7A6  -     chr16:68264516-68301823 +  16q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC7A6  -     16q22.1   [Description]    (hg19-Feb_2009)
EnsemblSLC7A6 - 16q22.1 [CytoView hg19]  SLC7A6 - 16q22.1 [CytoView hg38]
Mapping of homologs : NCBISLC7A6 [Mapview hg19]  SLC7A6 [Mapview hg38]
OMIM605641   
Gene and transcription
Genbank (Entrez)AK310602 AK310866 AK311610 BC028216 BC113100
RefSeq transcript (Entrez)NM_001076785 NM_003983
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLC7A6
Cluster EST : UnigeneHs.679580 [ NCBI ]
CGAP (NCI)Hs.679580
Alternative Splicing GalleryENSG00000103064
Gene ExpressionSLC7A6 [ NCBI-GEO ]   SLC7A6 [ EBI - ARRAY_EXPRESS ]   SLC7A6 [ SEEK ]   SLC7A6 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC7A6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9057
GTEX Portal (Tissue expression)SLC7A6
Human Protein AtlasENSG00000103064-SLC7A6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92536   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92536  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92536
Splice isoforms : SwissVarQ92536
PhosPhoSitePlusQ92536
Domains : Interpro (EBI)AA/rel_permease1   
Domain families : Pfam (Sanger)AA_permease_2 (PF13520)   
Domain families : Pfam (NCBI)pfam13520   
Conserved Domain (NCBI)SLC7A6
DMDM Disease mutations9057
Blocks (Seattle)SLC7A6
SuperfamilyQ92536
Human Protein Atlas [tissue]ENSG00000103064-SLC7A6 [tissue]
Peptide AtlasQ92536
HPRD12031
IPIIPI00644701   IPI00470878   
Protein Interaction databases
DIP (DOE-UCLA)Q92536
IntAct (EBI)Q92536
FunCoupENSG00000103064
BioGRIDSLC7A6
STRING (EMBL)SLC7A6
ZODIACSLC7A6
Ontologies - Pathways
QuickGOQ92536
Ontology : AmiGOplasma membrane  plasma membrane  integral component of plasma membrane  protein complex assembly  cellular amino acid metabolic process  transport  amino acid transport  amino acid transmembrane transporter activity  L-amino acid transmembrane transporter activity  antiporter activity  basolateral plasma membrane  intracellular membrane-bounded organelle  leukocyte migration  L-alpha-amino acid transmembrane transport  
Ontology : EGO-EBIplasma membrane  plasma membrane  integral component of plasma membrane  protein complex assembly  cellular amino acid metabolic process  transport  amino acid transport  amino acid transmembrane transporter activity  L-amino acid transmembrane transporter activity  antiporter activity  basolateral plasma membrane  intracellular membrane-bounded organelle  leukocyte migration  L-alpha-amino acid transmembrane transport  
NDEx NetworkSLC7A6
Atlas of Cancer Signalling NetworkSLC7A6
Wikipedia pathwaysSLC7A6
Orthology - Evolution
OrthoDB9057
GeneTree (enSembl)ENSG00000103064
Phylogenetic Trees/Animal Genes : TreeFamSLC7A6
HOVERGENQ92536
HOGENOMQ92536
Homologs : HomoloGeneSLC7A6
Homology/Alignments : Family Browser (UCSC)SLC7A6
Gene fusions - Rearrangements
Fusion : MitelmanESRP2/SLC7A6 [16q22.1/16q22.1]  [t(16;16)(q22;q22)]  
Fusion : MitelmanRANBP10/SLC7A6 [16q22.1/16q22.1]  [t(16;16)(q22;q22)]  
Fusion : MitelmanSLC7A6/GRXCR1 [16q22.1/4p13]  [t(4;16)(p13;q22)]  
Fusion : MitelmanSLC7A6/NFATC3 [16q22.1/16q22.1]  [t(16;16)(q22;q22)]  
Fusion: TCGA_MDACCESRP2 16q22.1 SLC7A6 16q22.1 BRCA
Fusion: TCGA_MDACCRANBP10 16q22.1 SLC7A6 16q22.1 LUAD
Fusion: TCGA_MDACCSLC7A6 16q22.1 GRXCR1 4p13 LUAD
Fusion: TCGA_MDACCSLC7A6 16q22.1 NFATC3 16q22.1 LUAD
Tumor Fusion PortalSLC7A6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC7A6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC7A6
dbVarSLC7A6
ClinVarSLC7A6
1000_GenomesSLC7A6 
Exome Variant ServerSLC7A6
ExAC (Exome Aggregation Consortium)ENSG00000103064
GNOMAD BrowserENSG00000103064
Genetic variants : HAPMAP9057
Genomic Variants (DGV)SLC7A6 [DGVbeta]
DECIPHERSLC7A6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC7A6 
Mutations
ICGC Data PortalSLC7A6 
TCGA Data PortalSLC7A6 
Broad Tumor PortalSLC7A6
OASIS PortalSLC7A6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC7A6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC7A6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC7A6
DgiDB (Drug Gene Interaction Database)SLC7A6
DoCM (Curated mutations)SLC7A6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC7A6 (select a term)
intoGenSLC7A6
Cancer3DSLC7A6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605641   
Orphanet
DisGeNETSLC7A6
MedgenSLC7A6
Genetic Testing Registry SLC7A6
NextProtQ92536 [Medical]
TSGene9057
GENETestsSLC7A6
Target ValidationSLC7A6
Huge Navigator SLC7A6 [HugePedia]
snp3D : Map Gene to Disease9057
BioCentury BCIQSLC7A6
ClinGenSLC7A6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9057
Chemical/Pharm GKB GenePA35924
Clinical trialSLC7A6
Miscellaneous
canSAR (ICR)SLC7A6 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC7A6
EVEXSLC7A6
GoPubMedSLC7A6
iHOPSLC7A6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:35:24 CET 2017

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