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SLC7A8 (solute carrier family 7 member 8)

Identity

Alias_namessolute carrier family 7 (amino acid transporter light chain, L system), member 8
Alias_symbol (synonym)LPI-PC1
LAT2
Other alias
HGNC (Hugo) SLC7A8
LocusID (NCBI) 23428
Atlas_Id 73489
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 23125295 and ends at 23155458 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANKS1A (6p21.31) / SLC7A8 (14q11.2)CDK5RAP2 (9q33.2) / SLC7A8 (14q11.2)RBM23 (14q11.2) / SLC7A8 (14q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC7A8   11066
Cards
Entrez_Gene (NCBI)SLC7A8  23428  solute carrier family 7 member 8
AliasesLAT2; LPI-PC1
GeneCards (Weizmann)SLC7A8
Ensembl hg19 (Hinxton)ENSG00000092068 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000092068 [Gene_View]  chr14:23125295-23155458 [Contig_View]  SLC7A8 [Vega]
ICGC DataPortalENSG00000092068
TCGA cBioPortalSLC7A8
AceView (NCBI)SLC7A8
Genatlas (Paris)SLC7A8
WikiGenes23428
SOURCE (Princeton)SLC7A8
Genetics Home Reference (NIH)SLC7A8
Genomic and cartography
GoldenPath hg38 (UCSC)SLC7A8  -     chr14:23125295-23155458 -  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC7A8  -     14q11.2   [Description]    (hg19-Feb_2009)
EnsemblSLC7A8 - 14q11.2 [CytoView hg19]  SLC7A8 - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBISLC7A8 [Mapview hg19]  SLC7A8 [Mapview hg38]
OMIM604235   
Gene and transcription
Genbank (Entrez)AB037669 AF087908 AF087911 AF135828 AF135829
RefSeq transcript (Entrez)NM_001267036 NM_001267037 NM_012244 NM_182728
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLC7A8
Cluster EST : UnigeneHs.596643 [ NCBI ]
CGAP (NCI)Hs.596643
Alternative Splicing GalleryENSG00000092068
Gene ExpressionSLC7A8 [ NCBI-GEO ]   SLC7A8 [ EBI - ARRAY_EXPRESS ]   SLC7A8 [ SEEK ]   SLC7A8 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC7A8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23428
GTEX Portal (Tissue expression)SLC7A8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHI5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHI5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHI5
Splice isoforms : SwissVarQ9UHI5
PhosPhoSitePlusQ9UHI5
Domains : Interpro (EBI)AA/rel_permease1    L_AA_transporter   
Domain families : Pfam (Sanger)AA_permease_2 (PF13520)   
Domain families : Pfam (NCBI)pfam13520   
Conserved Domain (NCBI)SLC7A8
DMDM Disease mutations23428
Blocks (Seattle)SLC7A8
SuperfamilyQ9UHI5
Human Protein AtlasENSG00000092068
Peptide AtlasQ9UHI5
HPRD11971
IPIIPI00296114   IPI00910859   IPI00385213   IPI00871769   IPI01018336   IPI00384119   IPI00332639   IPI00976955   IPI00909415   IPI00977614   IPI00978319   IPI00975642   
Protein Interaction databases
DIP (DOE-UCLA)Q9UHI5
IntAct (EBI)Q9UHI5
FunCoupENSG00000092068
BioGRIDSLC7A8
STRING (EMBL)SLC7A8
ZODIACSLC7A8
Ontologies - Pathways
QuickGOQ9UHI5
Ontology : AmiGOprotein binding  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  cellular amino acid metabolic process  transport  amino acid transport  amino acid transport  response to toxic substance  organic cation transmembrane transporter activity  amino acid transmembrane transporter activity  amino acid transmembrane transporter activity  amino acid transmembrane transporter activity  neutral amino acid transmembrane transporter activity  L-amino acid transmembrane transporter activity  antiporter activity  organic cation transport  neutral amino acid transport  basolateral plasma membrane  toxin transporter activity  peptide antigen binding  leukocyte migration  metal ion homeostasis  extracellular exosome  toxin transport  L-alpha-amino acid transmembrane transport  
Ontology : EGO-EBIprotein binding  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  cellular amino acid metabolic process  transport  amino acid transport  amino acid transport  response to toxic substance  organic cation transmembrane transporter activity  amino acid transmembrane transporter activity  amino acid transmembrane transporter activity  amino acid transmembrane transporter activity  neutral amino acid transmembrane transporter activity  L-amino acid transmembrane transporter activity  antiporter activity  organic cation transport  neutral amino acid transport  basolateral plasma membrane  toxin transporter activity  peptide antigen binding  leukocyte migration  metal ion homeostasis  extracellular exosome  toxin transport  L-alpha-amino acid transmembrane transport  
Pathways : KEGGProtein digestion and absorption   
NDEx NetworkSLC7A8
Atlas of Cancer Signalling NetworkSLC7A8
Wikipedia pathwaysSLC7A8
Orthology - Evolution
OrthoDB23428
GeneTree (enSembl)ENSG00000092068
Phylogenetic Trees/Animal Genes : TreeFamSLC7A8
HOVERGENQ9UHI5
HOGENOMQ9UHI5
Homologs : HomoloGeneSLC7A8
Homology/Alignments : Family Browser (UCSC)SLC7A8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC7A8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC7A8
dbVarSLC7A8
ClinVarSLC7A8
1000_GenomesSLC7A8 
Exome Variant ServerSLC7A8
ExAC (Exome Aggregation Consortium)SLC7A8 (select the gene name)
Genetic variants : HAPMAP23428
Genomic Variants (DGV)SLC7A8 [DGVbeta]
DECIPHERSLC7A8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC7A8 
Mutations
ICGC Data PortalSLC7A8 
TCGA Data PortalSLC7A8 
Broad Tumor PortalSLC7A8
OASIS PortalSLC7A8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC7A8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC7A8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC7A8
DgiDB (Drug Gene Interaction Database)SLC7A8
DoCM (Curated mutations)SLC7A8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC7A8 (select a term)
intoGenSLC7A8
Cancer3DSLC7A8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604235   
Orphanet
MedgenSLC7A8
Genetic Testing Registry SLC7A8
NextProtQ9UHI5 [Medical]
TSGene23428
GENETestsSLC7A8
Huge Navigator SLC7A8 [HugePedia]
snp3D : Map Gene to Disease23428
BioCentury BCIQSLC7A8
ClinGenSLC7A8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23428
Chemical/Pharm GKB GenePA35926
Clinical trialSLC7A8
Miscellaneous
canSAR (ICR)SLC7A8 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC7A8
EVEXSLC7A8
GoPubMedSLC7A8
iHOPSLC7A8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:53:50 CEST 2017

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