Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SLC8A2 (solute carrier family 8 member A2)

Identity

Alias_namessolute carrier family 8 (sodium/calcium exchanger)
Alias_symbol (synonym)NCX2
KIAA1087
Other alias
HGNC (Hugo) SLC8A2
LocusID (NCBI) 6543
Atlas_Id 51575
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 47428022 and ends at 47472050 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SLC8A2 (19q13.32) / DHX34 (19q13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC8A2   11069
Cards
Entrez_Gene (NCBI)SLC8A2  6543  solute carrier family 8 member A2
AliasesNCX2
GeneCards (Weizmann)SLC8A2
Ensembl hg19 (Hinxton)ENSG00000118160 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118160 [Gene_View]  chr19:47428022-47472050 [Contig_View]  SLC8A2 [Vega]
ICGC DataPortalENSG00000118160
TCGA cBioPortalSLC8A2
AceView (NCBI)SLC8A2
Genatlas (Paris)SLC8A2
WikiGenes6543
SOURCE (Princeton)SLC8A2
Genetics Home Reference (NIH)SLC8A2
Genomic and cartography
GoldenPath hg38 (UCSC)SLC8A2  -     chr19:47428022-47472050 -  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC8A2  -     19q13.32   [Description]    (hg19-Feb_2009)
EnsemblSLC8A2 - 19q13.32 [CytoView hg19]  SLC8A2 - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBISLC8A2 [Mapview hg19]  SLC8A2 [Mapview hg38]
OMIM601901   
Gene and transcription
Genbank (Entrez)AB029010 AK293457 AK293836 AK293860 AK302552
RefSeq transcript (Entrez)NM_015063
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLC8A2
Cluster EST : UnigeneHs.172884 [ NCBI ]
CGAP (NCI)Hs.172884
Alternative Splicing GalleryENSG00000118160
Gene ExpressionSLC8A2 [ NCBI-GEO ]   SLC8A2 [ EBI - ARRAY_EXPRESS ]   SLC8A2 [ SEEK ]   SLC8A2 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC8A2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6543
GTEX Portal (Tissue expression)SLC8A2
Human Protein AtlasENSG00000118160-SLC8A2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UPR5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UPR5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UPR5
Splice isoforms : SwissVarQ9UPR5
PhosPhoSitePlusQ9UPR5
Domains : Interpro (EBI)Calx_beta    Na_Ca_Ex    Na_Ca_Ex_C-exten    NaCa_Exmemb   
Domain families : Pfam (Sanger)Calx-beta (PF03160)    Na_Ca_ex (PF01699)    Na_Ca_ex_C (PF16494)   
Domain families : Pfam (NCBI)pfam03160    pfam01699    pfam16494   
Domain families : Smart (EMBL)Calx_beta (SM00237)  
Conserved Domain (NCBI)SLC8A2
DMDM Disease mutations6543
Blocks (Seattle)SLC8A2
SuperfamilyQ9UPR5
Human Protein Atlas [tissue]ENSG00000118160-SLC8A2 [tissue]
Peptide AtlasQ9UPR5
HPRD15990
IPIIPI00010343   IPI00385612   IPI01015685   IPI01015476   
Protein Interaction databases
DIP (DOE-UCLA)Q9UPR5
IntAct (EBI)Q9UPR5
FunCoupENSG00000118160
BioGRIDSLC8A2
STRING (EMBL)SLC8A2
ZODIACSLC8A2
Ontologies - Pathways
QuickGOQ9UPR5
Ontology : AmiGOcalcium:sodium antiporter activity  calcium:sodium antiporter activity  calmodulin binding  plasma membrane  integral component of plasma membrane  ion transport  cellular calcium ion homeostasis  cell communication  learning  memory  basolateral plasma membrane  sodium ion transmembrane transport  dendritic spine  perikaryon  metal ion binding  regulation of short-term neuronal synaptic plasticity  long-term synaptic potentiation  calcium ion transmembrane transport  regulation of cardiac conduction  
Ontology : EGO-EBIcalcium:sodium antiporter activity  calcium:sodium antiporter activity  calmodulin binding  plasma membrane  integral component of plasma membrane  ion transport  cellular calcium ion homeostasis  cell communication  learning  memory  basolateral plasma membrane  sodium ion transmembrane transport  dendritic spine  perikaryon  metal ion binding  regulation of short-term neuronal synaptic plasticity  long-term synaptic potentiation  calcium ion transmembrane transport  regulation of cardiac conduction  
Pathways : KEGGCalcium signaling pathway    Protein digestion and absorption   
NDEx NetworkSLC8A2
Atlas of Cancer Signalling NetworkSLC8A2
Wikipedia pathwaysSLC8A2
Orthology - Evolution
OrthoDB6543
GeneTree (enSembl)ENSG00000118160
Phylogenetic Trees/Animal Genes : TreeFamSLC8A2
HOVERGENQ9UPR5
HOGENOMQ9UPR5
Homologs : HomoloGeneSLC8A2
Homology/Alignments : Family Browser (UCSC)SLC8A2
Gene fusions - Rearrangements
Tumor Fusion PortalSLC8A2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC8A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC8A2
dbVarSLC8A2
ClinVarSLC8A2
1000_GenomesSLC8A2 
Exome Variant ServerSLC8A2
ExAC (Exome Aggregation Consortium)ENSG00000118160
GNOMAD BrowserENSG00000118160
Genetic variants : HAPMAP6543
Genomic Variants (DGV)SLC8A2 [DGVbeta]
DECIPHERSLC8A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC8A2 
Mutations
ICGC Data PortalSLC8A2 
TCGA Data PortalSLC8A2 
Broad Tumor PortalSLC8A2
OASIS PortalSLC8A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC8A2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC8A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC8A2
DgiDB (Drug Gene Interaction Database)SLC8A2
DoCM (Curated mutations)SLC8A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC8A2 (select a term)
intoGenSLC8A2
Cancer3DSLC8A2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601901   
Orphanet
DisGeNETSLC8A2
MedgenSLC8A2
Genetic Testing Registry SLC8A2
NextProtQ9UPR5 [Medical]
TSGene6543
GENETestsSLC8A2
Target ValidationSLC8A2
Huge Navigator SLC8A2 [HugePedia]
snp3D : Map Gene to Disease6543
BioCentury BCIQSLC8A2
ClinGenSLC8A2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6543
Chemical/Pharm GKB GenePA313
Clinical trialSLC8A2
Miscellaneous
canSAR (ICR)SLC8A2 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC8A2
EVEXSLC8A2
GoPubMedSLC8A2
iHOPSLC8A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:35:25 CET 2017

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