SLC8A3 (solute carrier family 8 member A3)

2014-11-01  

Identity

HGNC
LOCATION
14q24.2
LOCUSID
ALIAS
NCX3
FUSION GENES

Other Information

Locus ID:

NCBI: 6547
MIM: 607991
HGNC: 11070
Ensembl: ENSG00000100678

Variants:

dbSNP: 6547
ClinVar: 6547
TCGA: ENSG00000100678
COSMIC: SLC8A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100678ENST00000216568P57103
ENSG00000100678ENST00000356921P57103
ENSG00000100678ENST00000357887P57103
ENSG00000100678ENST00000381269P57103
ENSG00000100678ENST00000394330P57103
ENSG00000100678ENST00000494208P57103
ENSG00000100678ENST00000528359P57103
ENSG00000100678ENST00000533541F2Z391
ENSG00000100678ENST00000534137P57103

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Olfactory transductionKEGGko04740
Calcium signaling pathwayKEGGhsa04020
Olfactory transductionKEGGhsa04740
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Reduction of cytosolic Ca++ levelsREACTOMER-HSA-418359
Muscle contractionREACTOMER-HSA-397014
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Sodium/Calcium exchangersREACTOMER-HSA-425561
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775
Apelin signaling pathwayKEGGhsa04371

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
163063952005Downstream regulatory element antagonist modulator regulates Ca2+ homeostasis and viability in cerebellar neurons.34
218581952011Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle.27
219599352012Silencing or knocking out the Na(+)/Ca(2+) exchanger-3 (NCX3) impairs oligodendrocyte differentiation.26
213826382011High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease.13
232248832013NCX as a key player in the neuroprotection exerted by ischemic preconditioning and postconditioning.10
232248842013The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease.10
232248902013New roles of NCX in glial cells: activation of microglia in ischemia and differentiation of oligodendrocytes.10
239196772014Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease.8
166793222006Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins.7

Citation

Dessen P

SLC8A3 (solute carrier family 8 member A3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73493/slc8a3