Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SLC8A3 (solute carrier family 8 (sodium/calcium exchanger), member 3)

Identity

Alias_namessolute carrier family 8 (sodium/calcium exchanger), member 3
Alias_symbol (synonym)NCX3
Other alias
HGNC (Hugo) SLC8A3
LocusID (NCBI) 6547
Atlas_Id 73493
Location 14q24.2  [Link to chromosome band 14q24]
Location_base_pair Starts at 70510934 and ends at 70546934 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
B3GAT3 (11q12.3) / SLC8A3 (14q24.2)SLC8A3 (14q24.2) / MEIS3 (19q13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC8A3   11070
Cards
Entrez_Gene (NCBI)SLC8A3  6547  solute carrier family 8 (sodium/calcium exchanger), member 3
AliasesNCX3
GeneCards (Weizmann)SLC8A3
Ensembl hg19 (Hinxton)ENSG00000100678 [Gene_View]  chr14:70510934-70546934 [Contig_View]  SLC8A3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000100678 [Gene_View]  chr14:70510934-70546934 [Contig_View]  SLC8A3 [Vega]
ICGC DataPortalENSG00000100678
TCGA cBioPortalSLC8A3
AceView (NCBI)SLC8A3
Genatlas (Paris)SLC8A3
WikiGenes6547
SOURCE (Princeton)SLC8A3
Genetics Home Reference (NIH)SLC8A3
Genomic and cartography
GoldenPath hg19 (UCSC)SLC8A3  -     chr14:70510934-70546934 -  14q24.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SLC8A3  -     14q24.2   [Description]    (hg38-Dec_2013)
EnsemblSLC8A3 - 14q24.2 [CytoView hg19]  SLC8A3 - 14q24.2 [CytoView hg38]
Mapping of homologs : NCBISLC8A3 [Mapview hg19]  SLC8A3 [Mapview hg38]
OMIM607991   
Gene and transcription
Genbank (Entrez)AF510501 AF510502 AF510503 AJ304852 AJ304853
RefSeq transcript (Entrez)NM_001130417 NM_033262 NM_058240 NM_182932 NM_182933 NM_182936 NM_183002
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)SLC8A3
Cluster EST : UnigeneHs.337696 [ NCBI ]
CGAP (NCI)Hs.337696
Alternative Splicing GalleryENSG00000100678
Gene ExpressionSLC8A3 [ NCBI-GEO ]   SLC8A3 [ EBI - ARRAY_EXPRESS ]   SLC8A3 [ SEEK ]   SLC8A3 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC8A3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6547
GTEX Portal (Tissue expression)SLC8A3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57103   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57103  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57103
Splice isoforms : SwissVarP57103
PhosPhoSitePlusP57103
Domains : Interpro (EBI)Calx_beta    Na_Ca_Ex    NaCa_Exmemb   
Domain families : Pfam (Sanger)Calx-beta (PF03160)    Na_Ca_ex (PF01699)   
Domain families : Pfam (NCBI)pfam03160    pfam01699   
Domain families : Smart (EMBL)Calx_beta (SM00237)  
Conserved Domain (NCBI)SLC8A3
DMDM Disease mutations6547
Blocks (Seattle)SLC8A3
SuperfamilyP57103
Human Protein AtlasENSG00000100678
Peptide AtlasP57103
HPRD09723
IPIIPI00337727   IPI00337400   IPI00337399   IPI00909878   IPI00376107   IPI00871381   IPI00289936   IPI00983219   
Protein Interaction databases
DIP (DOE-UCLA)P57103
IntAct (EBI)P57103
FunCoupENSG00000100678
BioGRIDSLC8A3
STRING (EMBL)SLC8A3
ZODIACSLC8A3
Ontologies - Pathways
QuickGOP57103
Ontology : AmiGOhematopoietic progenitor cell differentiation  calcium:sodium antiporter activity  calmodulin binding  mitochondrion  microtubule  plasma membrane  ion transport  cell communication  blood coagulation  integral component of membrane  telencephalon development  sodium ion transmembrane transport  sarcolemma  neuronal cell body  dendritic spine  transmembrane transport  calcium ion transport into cytosol  calcium ion transmembrane transport  cellular response to cAMP  calcium ion export from cell  calcium ion import into cell  
Ontology : EGO-EBIhematopoietic progenitor cell differentiation  calcium:sodium antiporter activity  calmodulin binding  mitochondrion  microtubule  plasma membrane  ion transport  cell communication  blood coagulation  integral component of membrane  telencephalon development  sodium ion transmembrane transport  sarcolemma  neuronal cell body  dendritic spine  transmembrane transport  calcium ion transport into cytosol  calcium ion transmembrane transport  cellular response to cAMP  calcium ion export from cell  calcium ion import into cell  
Pathways : KEGGCalcium signaling pathway    Protein digestion and absorption   
NDEx NetworkSLC8A3
Atlas of Cancer Signalling NetworkSLC8A3
Wikipedia pathwaysSLC8A3
Orthology - Evolution
OrthoDB6547
GeneTree (enSembl)ENSG00000100678
Phylogenetic Trees/Animal Genes : TreeFamSLC8A3
HOVERGENP57103
HOGENOMP57103
Homologs : HomoloGeneSLC8A3
Homology/Alignments : Family Browser (UCSC)SLC8A3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC8A3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC8A3
dbVarSLC8A3
ClinVarSLC8A3
1000_GenomesSLC8A3 
Exome Variant ServerSLC8A3
ExAC (Exome Aggregation Consortium)SLC8A3 (select the gene name)
Genetic variants : HAPMAP6547
Genomic Variants (DGV)SLC8A3 [DGVbeta]
DECIPHER (Syndromes)14:70510934-70546934  ENSG00000100678
CONAN: Copy Number AnalysisSLC8A3 
Mutations
ICGC Data PortalSLC8A3 
TCGA Data PortalSLC8A3 
Broad Tumor PortalSLC8A3
OASIS PortalSLC8A3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC8A3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC8A3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC8A3
DgiDB (Drug Gene Interaction Database)SLC8A3
DoCM (Curated mutations)SLC8A3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC8A3 (select a term)
intoGenSLC8A3
Cancer3DSLC8A3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607991   
Orphanet
MedgenSLC8A3
Genetic Testing Registry SLC8A3
NextProtP57103 [Medical]
TSGene6547
GENETestsSLC8A3
Huge Navigator SLC8A3 [HugePedia]
snp3D : Map Gene to Disease6547
BioCentury BCIQSLC8A3
ClinGenSLC8A3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6547
Chemical/Pharm GKB GenePA315
Clinical trialSLC8A3
Miscellaneous
canSAR (ICR)SLC8A3 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC8A3
EVEXSLC8A3
GoPubMedSLC8A3
iHOPSLC8A3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:43:57 CET 2017

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